[1] CHEN YL, ZHANG SY, WANG QZ, et al.Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein[J].J Hemato Oncol, 2017, 10:36. doi: 10.1186/s13045-017-0408-0
[2] PARK JY, VON KARSA L, HERRERO R.Prevention strategies for gastric cancer:a global perspective[J].Clin Endosc, 2014, 47(6):478. doi: 10.5946/ce.2014.47.6.478
[3] HUANG Z, ZHU D, WU L, et al.Six serum-based miRNAs as potential diagnostic biomarkers for gastric cancer[J].Cancer Epidemiol Biomarkers Prev, 2017, 26(2):188. doi: 10.1158/1055-9965.EPI-16-0607
[4] SHAO QW, XU JING, GUAN XIN, et al.In vitro and in vivo effects of miRNA-19b/20a/92a on gastric cancer stem cells and the related mechanism[J].Int J Med Sci, 2018, 15(1):86. doi: 10.7150/ijms.21164
[5] HAN ME, JEON TY, HWANG SH, et al.Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research[J].Cell Mol Life Sci, 2011, 68(21):3589. doi: 10.1007/s00018-011-0672-z
[6] COLAK S, MEDEMA JP.Cancer stem cells-important players in tumor therapy resistance[J].FEBS J, 2014, 281(21):4779. doi: 10.1111/febs.13023
[7] BOCKHORN J, YEE K, CHANG YF, et al.MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion[J].Breast Cancer Res Treat, 2013, 137(2):373. doi: 10.1007/s10549-012-2346-4
[8] LIN CW, CHANG YL, CHANG YC, et al.MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1[J].Nat Commun, 2013, 4:1877. doi: 10.1038/ncomms2876
[9] YANG F, WEI J, ZHANG S, et al.Shrimp miR-S8 suppresses the stemness of human melanoma stem-like cells by targeting the transcription factor YB-1[J].Cancer Res, 2017, 77(20):5543. doi: 10.1158/0008-5472.CAN-17-1375
[10] ZHANG XW, HUA RX, WANG XF, et al.Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer[J].Oncotarget, 2016, 7(9):9815.
[11] LAWRENCE N, CHIN KL.The metastasis problem gets stickier[J].Cancer Cell, 2009, 15(1):1. doi: 10.1016/j.ccr.2008.12.007
[12] GRIMSHAW MJ, COOPER L, PAPAZISIS K, et al.Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells[J].Breast Cancer Res, 2008, 10(3):R52.
[13] HAN ME, JEON TY, HWANG SH, et al.Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research[J].Cell Mol Life Sci, 2011, 68(21):3589. doi: 10.1007/s00018-011-0672-z
[14] SONG Z, YUE W, WEI B, et al.Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer[J].PLoS One, 2011, 6(3):e17687. doi: 10.1371/journal.pone.0017687
[15] JEMAL A, BRAY F, CENTER MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61(2):69. doi: 10.3322/caac.v61:2
[16] HUANG Y, LI LP.Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review)[J].Oncol Lett, 2014, 8(2):493.
[17] SHI X, WANG X.The role of MTDH/AEG-1 in the progression of cancer[J].Int J Clin Exp Med, 2015, 8(4):4795.
[18] CHEN X, DONG K, LONG M, et al.Serum anti-AEG-1 autoantibody is a potential novel biomarker for malignant tumors[J].Oncol Lett, 2012, 4(2):319. doi: 10.3892/ol.2012.734
[19] LIU H, SONG X, LIU C, et al.Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells[J].J Exp Clin Cancer Res, 2009, 28:19. doi: 10.1186/1756-9966-28-19
[20] EMDAD L, LEE SG, SU ZZ, et al.Astrocyte elevated gene-1(AEG-1) functions as an oncogene and regulates angiogenesis[J].Proc Natl Acad Sci USA, 2009, 106(50):21300. doi: 10.1073/pnas.0910936106
[21] SARKAR D, PARK ES, EMDAD L, et al.Molecular basis of nuclear factor-kappa B activation by astrocyte elevated gene-1[J].Cancer Res, 2008, 68(5):1478. doi: 10.1158/0008-5472.CAN-07-6164
[22] SONG L, LI W, ZHANG H, et al.Over-expression of AEG-1 significantly associates with tumour aggressiveness and poor prognosis in human non-small cell lung cancer[J].J Pathol, 2009, 219(3):317.
[23] PAN Y, GUO X, YANG Z, et al.AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma[J].Oncotarget, 2016, 7(2):2093.
[24] WEI Y, HU G, KANG Y.Metadherin as a link between metastasis and chemoresistance[J].Cell Cycle, 2009, 8(14):2132.
[25] HUANG W, YANG L, LIANG S, et al.AEG-1 is a target of perifosine and is over-expressed in gastric dysplasia and cancers[J].Dig Dis Sci, 2013, 58(10):2873. doi: 10.1007/s10620-013-2735-5
[26] HATFIELD S, RUOHOLA-BAKER H.microRNA and stem cell function[J].Cell Tissue Res, 2008, 331(1):57.
[27] LEE SG, SU ZZ, EMDAD L, et al.Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling[J].Oncogene, 2008, 27(8):1114. doi: 10.1038/sj.onc.1210713
[28] SU P, ZHANG Q, YANG Q.Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue[J].Diagn Pathol, 2010, 5:38. doi: 10.1186/1746-1596-5-38
[29] WANG J, CHEN X, TONG M.Knockdown of astrocyte elevated gene-1 inhibited cell growth and induced apoptosis and suppressed invasion in ovarian cancer cells[J].Gene, 2017, 616:8. doi: 10.1016/j.gene.2017.03.024
[30] QIAO W, CAO N, YANG L.microRNA 154 inhibits the growth and metastasis of gastric cancer cells by directly targeting MTDH[J].Oncol Lett, 2017, 14(3):3268. doi: 10.3892/ol.2017.6558
[31] LI J, YANG L, SONG L, et al.Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1[J].Oncogene, 2009, 28(36):3188. doi: 10.1038/onc.2009.171
[32] KE ZF, MAO X, ZENG C, et al.AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis[J].Med Oncol, 2013, 30(1):383. doi: 10.1007/s12032-012-0383-9
[33] CARMELIET P, JAIN RK.Angiogenesis in cancer and other diseases[J].Nature, 2000, 407(6801):249. doi: 10.1038/35025220
[34] SRIVASTAVA J, SIDDIQ A, EMDAD L, et al.Astrocyte elevated gene-1 promotes hepatocarcinogenesis:novel insights from a mouse model[J].Hepatology, 2012, 56(5):1782. doi: 10.1002/hep.25868