| [1] | LOPEZ-OTIN C,BLASCO MA,PARTRIDGE L,et al.The hallmarks of aging[J].Cell,2013,153(6):1194. |
| [2] | CHEN J,OU Y,YANG Y,et al.KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing[J].Nature,2018,557(7706):585. |
| [3] | KAEBERLEIN M,MCVEY M,GUARENTE L.The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms[J].Genes Dev,1999,13(19):2570. |
| [4] | ROGINA B,HELFAND SL.Sir2 mediates longevity in the fly through a pathway related to calorie restriction[J].Proc Natl Acad Sci U S A,2004,101(45):15998. |
| [5] | CHILDS BG,GLUSCEVIC M,BAKER DJ,et al.Senescent cells:an emerging target for diseases of ageing[J].Nat Rev Drug Discov,2017,16(10):718. |
| [6] | RHOADS TW,BURHANS MS,CHEN VB,et al.Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys[J].Cell Metab,2018,27(3):677. |
| [7] | HAYFLICK L,MOORHEAD PS.The serial cultivation of human diploid cell strains[J].Exp Cell Res,1961,25(3):585. |
| [8] | VAN DEURSEN JM.The role of senescent cells in ageing[J].Nature,2014,509(7501):439. |
| [9] | DIMRI GP,LEE X,BASILE G,et al.A biomarker that identifies senescent human cells in culture and in aging skin in vivo[J].Proc Natl Acad Sci U S A,1995,92(20):9363. |
| [10] | SHARPLESS NE,SHERR CJ.Forging a signature of in vivo senescence[J].Nat Rev Cancer,2015,15(7):397. |
| [11] | RODIER F,COPPE JP,PATIL CK,et al.Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion[J].Nat Cell Biol,2009,11(8):973. |
| [12] | KUILMAN T,PEEPER DS.Senescence-messaging secretome:SMS-ing cellular stress[J].Nat Rev Cancer,2009,9(2):81. |
| [13] | CHILDS BG,LI H,VAN DEURSEN JM.Senescent cells:a therapeutic target for cardiovascular disease[J].J Clin Invest,2018,128(4):1217. |
| [14] | JEON OH,KIM C,LABERGE RM,et al.Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment[J].Nat Med,2017,23(6):775. |
| [15] | CHEUNG P,VALLANIA F,WARSINSKE HC,et al.Single-cell chromatin modification profiling reveals increased epigenetic variations with aging[J].Cell,2018,173(6):1385. |
| [16] | EMILSSON V,ILKOV M,LAMB JR,et al.Co-regulatory networks of human serum proteins link genetics to disease[J].Science,2018,361(6404):769. |
| [17] | PARTRIDGE L,DEELEN J,SLAGBOOM PE.Facing up to the global challenges of ageing[J].Nature,2018,561(7721):45. |
| [18] | ZHANG W,WAN H,FENG G,et al.SIRT6 deficiency results in developmental retardation in cynomolgus monkeys[J].Nature,2018,560(7720):661. |
| [19] | GOLDMAN RD,SHUMAKER DK,ERDOS MR,et al.Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome[J].Proc Natl Acad Sci U S A,2004,101(24):8963. |
| [20] | HAJJAR J,HABRA MA,NAING A.Metformin:an old drug with new potential[J].Expert Opin Investig Drugs,2013,22(12):1511. |
| [21] | KANFI Y,NAIMAN S,AMIR G,et al.The sirtuin SIRT6 regulates lifespan in male mice[J].Nature,2012,483(7388):218. |
| [22] | PLUQUET O,POURTIER A,ABBADIE C.The unfolded protein response and cellular senescence.A review in the theme:cellular mechanisms of endoplasmic reticulum stress signaling in health and disease[J].Am J Physiol Cell Physiol,2015,308(6):C415. |
| [23] | MOLLIEX A,TEMIROV J,LEE J,et al.Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization[J].Cell,2015,163(1):123. |
| [24] | KENNEDY BK,BERGER SL,BRUNET A,et al.Geroscience:linking aging to chronic disease[J].Cell,2014,159(4):709. |
| [25] | ZHANG R,CHEN H,LIU DP.The Four Layers of Aging[J].Cell Systems,2015,1(3):180. |