[1] OTT JJ,STEVENS GA,GROEGER J,et al.Global epidemiology of hepatitis B virus infection:new estimates of age-specific HBsAg seroprevalence and endemicity[J].Vaccine,2012,30(12):2212.
[2] European Association for the Study of the Liver.EASL clinical practice guidelines:management of chronic hepatitis B virus infection[J].J Hepatol,2012,57(1):167.
[3] LIAW YF,KAO JH,PIRATVISUTH T,et al.Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2012 update[J].Hepatol Intern,2012,6(3):531.
[4] DURANTEL D,ZOULIM F.Innate response to hepatitis B virus infection:observations challenging the concept of a stealth virus[J].Hepatology,2009,50(6):1692.
[5] RALAINIRINA N,POLI A,MICHEL T,et al.Control of NK cell functions by CD4+CD25+regulatory T cells[J].J Leukoc Biol,2007,81(1):144.
[6] GUO PP,LI SP,WU W,et al.Circulating CD4+CD25+regulatory T cells correlate with chronic hepatitis B infection[J].Immunology,2008,123(1):57.
[7] PARK HJ,PARK JS,JEONG YH,et al.PD-1 Upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+T cell immune response via the interaction with PD-L1 expressed on CD8+T cells[J].J Immunol,2015,194(12):5801.
[8] JONES A,OPEJIN A,HENDERSON JG,et al.Peripherally induced tolerance depends on peripheral regulatory T cells that require hopx to inhibit intrinsic IL-2 expression[J].J Immunol,2015,195(4):1489.
[9] SAKAGUCHI S.Naturally arising Foxp3-expressing CD25+CD4+regulatory T cells in immunological tolerance to self and non-self[J].Nat Immunol,2005,6(4):345.
[10] LIU W,PUTNAM AL,XU-YU Z,et al.CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells[J].J Exp Med,2006,203(7):1701.
[11] MA H,ZHANG HH,WEI L.Frequency of T-cell FoxP3(+) Treg and CD4(+)/CD8(+) PD-1 expression is related to HBeAg seroconversion in hepatitis B patients on pegylated interferon[J].Chin Med J (Engl),2013,126(2):267.
[12] YU XP,GUO RY,SU ML,et al.Dynamic changes of Treg and Th17 cells and related cytokines closely correlate with the virological and biochemical response in chronic hepatitis B patients undergoing nucleos(t)ide analogues treatment[J].Hepat Mon,2013,13(12):e15332.
[13] 潘修成,杨帆,陈明,等.替比夫定对慢性乙型肝炎患者外周血CD4+CD25+调节性T细胞动态变化的影响及其临床意义[J].中华肝脏病杂志,2008,16(12):885.
[14] STOOP JN,VANDER MOLEN RG,KUIPERS EJ,et al.Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B[J].Virology,2007,361(1):141.
[15] YAN Z,ZHOU J,ZHANG M,et al.Telbivudine decreases proportion of peripheral blood CD4+CD25+CD127low T cells in parallel with inhibiting hepatitis B virus DNA[J].Mol Med Rep,2014,9(5):2024.