再生障碍性贫血患者外周血CD4~+CD25~+ T细胞的检测

王卫国; 马黎丽; 马芳; 李玉云; 王卫国; 马黎丽; 马芳; 李玉云

[2] Sakaguchi S.Naturally arising CD4 + regulatory T cell for immunologic self-tolerance and negative control of immune responses[J].Annu Rev Immunol,2004,22:531-562.

[2]

Young NS,Calado RT,Scheinberg P.Current concepts in the pathophysiology and treatment of aplastic anemia[J].Blood,2006,108(8):2509-2519.

[3] 何广胜,周玲,吴德沛,等.CD4 + 调节性T 细胞在再生障碍性贫血免疫发病中的作用[J].中国实用内科杂志,2007,27(20):1599-1601.

[4] 王雪野,韩梅,杨广民,等.再生障碍性贫血患者外周血CD4+CD25+调节性T 细胞及Foxp3 的变化及临床意义[J].中国免疫学杂志,2009,25(3):271-274.

[5] 张之南,沈悌.血液病诊断与疗效标准[M].3 版.北京:科学出版社,2007:19-23.

[6] Feng X,Kajigaya S,Solomou EE,et al.Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25high FOXP3 +regulatory T cells in vitro[J].Blood,2008,111(7):3675-3683.

[7] 李玉云,王卫国,张强,等.CD4 + CD25 + Treg 细胞和IL-21 与再生障碍性贫血发病关系的探讨[J].中华血液学杂志,2010,31(4):269-270.

[8] Baecher-Allan C,Brown JA,Freeman GJ,et al.CD4 + CD25highregulatory cells in human peripheral blood[J].Immunol,2001,167(3):1245-1253.

[9] Chen J,Ellison FM,Eckhaus MA,et al.Minor antigen h60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells[J].J Immunol,2007,178(7):4159-4168.