肿瘤多药耐药机制及逆转策略的研究进展
-
摘要: 一般肿瘤耐药性是指肿瘤细胞对一种抗癌药耐药,可能对结构和功能相似的药物产生交叉耐药性,而对非同类型的药物仍敏感。但是现在更为普遍的是肿瘤多药耐药性(multidrug resistance,MDR),MDR现象由Biedler等[1]在1970年首次发现,是指肿瘤细胞对一种抗肿瘤药物耐药,对非同类型的结构和功能机制不同的药物也产生耐药,这是导致肿瘤药物治疗失败的主要原因:因此,研究MDR产生的分子机制并探寻逆转策略是目前肿瘤研究的一个热点,本文就该领域研究进展作一综述。
-
[1] BiedleRJL,Riehm H. CellulaRresistance to actinomycin D in Chinese hamsteRcells in vitro:cross-resistance,radioautographic, and cytogenetic studies[J]. CanceRRes,1970,30(4):1174-1184. [2] [2] Yan F,Jiang Y,Li YM,et al. Reversal of P-glycoprotein and multidrug resistance-associated protein 1 mediated multidrug resistance in canceRcells by HZ08 Isomers,tetrataisohydroquinolin derivatives[J]. Biol Pharm Bull,2008,31(6):1258-1264. [3] [3] AlleRSG,Yu J,Ward A,et al. Structure of P-glycoprotein reveals a moleculaRbasis foRpoly-specific drug binding[J]. Science,2009, 323(5922):1718-1722. [4] [4] Klepsch F,Jabeen I,Chiba P,et al. Pharmacoinformatic approaches to design natural product type ligands of ABC-transporters[J]. CurRPharm Des,2010,16(15):1742-1752. [5] [5] Kitazono M,Okumura H,Ikeda R,et al. Reversal of LRP-associated drug resistance in colon carcinoma SW-620 cells[J]. Int J Cancer,2001,91(1):126-131. [6] [6] Hung JY,Hsu YL,Ko YC,et al. Didymin,a dietary flavonoid glycoside from citrus fruits,induces Fas-mediated apoptotic pathway in human non-small-cell lung canceRcells in vitro and in vivo[J]. Lung Cancer,2010,68(3):366-374. [7] [7] Park SE,Park C,Kim SH,et al. Korean red ginseng extract induces apoptosis and decreases telomerase activity in human leukemia cells[J]. J Ethnopharmacol,2009,121(2):304-312. [8] [8] Weston RT,Puthalakath H. Endoplasmic reticulum stress and BCL-2 family members[J]. Adv Exp Med Biol,2010,687(5):65-77. [9] [9] Gallenne T,GautieRF,OliveRL,et al. Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members[J]. J Cell Biol,2009,185(2):279-290. [10] [10] Ghosh AP,Walls KC,Klocke BJ,et al. The proapoptotic BH3-only,Bcl-2 family member,Puma is critical foRacute ethanol-induced neuronal apoptosis[J]. J Neuropathol Exp Neurol,2009, 68(7):747-756. [11] [11] Shangary S,Wang S. Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function:a novel approach foRcanceRtherapy[J]. Annu Rev Pharmacol Toxicol, 2009,49(2):223-241. [12] [12] Burguillos MA,Hajji N,Englund E,et al. Apoptosis-inducing factoRmediates dopaminergic cell death in response to LPS-induced inflammatory stimulus:evidence in Parkinson' s disease patients[J]. Neurobiol Dis,2010,41(1):177-188. [13] [13] Guo C,Li Y,Zhang H,et al. Enhancement of antiproliferative and proapoptotic effects of cadmium chloride combined with hSmac in hepatocellulaRcarcinoma cells[J]. Chemotherapy,2011,57(1):27-34. [14] [14] Lu H,Gan M,Zhang G,et al. Expression of survivin,caspase-3 and p53 in cervical canceRassessed by tissue microarray:correlation with clinicopathology and prognosis [J]. EuRJ Gynaecol Oncol,2010,31(6):662-666. [15] [15] Chen Z,Liang K,Liu J,et al. Enhancement of survivin gene downregulation and cell apoptosis by a novel combination:liposome microbubbles and ultrasound exposure[J]. Med Oncol, 2009,26(4):491-500. [16] [16] Schindlbeck C,MayRD,OlivieRC,et al. Topoisomerase IIalpha expression ratheRthan gene amplification predicts responsiveness of adjuvant anthracycline-based chemotherapy in women with
点击查看大图
计量
- 文章访问数: 3400
- HTML全文浏览量: 341
- PDF下载量: 164
- 被引次数: 0