microRNA在甲状腺癌中的研究进展
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摘要: microRNA(miR)是一种由21~25个碱基组成的非编码RNA,通过与mRNA互补,诱导mRNA降解或翻译抑制。miR表达异常出现在多种肿瘤中,据此推测miR在人类肿瘤发生、发展过程中扮演着重要角色。甲状腺癌为内分泌系统最常见的恶性肿瘤。miR在甲状腺癌发生、发展中发挥重要作用,其有可能成为诊断甲状腺癌的分子标志,并为甲状腺癌的治疗带来新的机遇。本文就miR在甲状腺癌中的研究进展作一综述。1 miR概述miR是一种非蛋白编码的单链小分子RNA,自Lee等[1]
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[1] [2］ Lewis BP，Burge CB，Bartel DP． Conserved seed pairing，often flanked by adenosines，indicates that thousands of human genes are microRNA targets［J]. Cell，2005，120(1):15-20. [2] Lee R，Feinbaum R，Ambros V． A short history of a short RNA ［J]. Cell，2004，116(2):S89-S92. [3] [3］ Ambros V，Bartel B，Bartel DP，et al． A uniform system for microRNA annotation［J]. RNA，2003，9(3):277-279. [4] [4］ Lee Y，Ahn C，Han J，et al． The nucleaRRNase III Drosha initiates microRNA processing［J]. Nature，2003，425(6956):415-419. [5] [5］ Yi R，Qin Y，Macara IG，et al． Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs［J]. Genes Dev， 2003，17(24):3011-3016. [6] [6］ HutvagneRG，McLachlan J，Pasquinelli AE，et al． A cellular function foRthe RNA-interference enzyme diceRin the maturation of the let-7 small temporal RNA［J]. Science，2001，293(5531):834-838. [7] [7］ Bartel DP． MicroRNAs:genomics，biogenesis，mechanism，and function［J]. Cell，2004，116(2):281-297. [8] [8］ Zhang W，Dahlberg JE，Tam W． MicroRNAs in tumorigenesis:a primer［J]. Pathology，2007，171(3):728-738. [9] [9］ Sassen S，Miska EA，Caldas C． MicroRNA:implications foRcancer ［J]. Virchows Arch，2008，452(1):1-10. [10] [10］ Michael MZ，O' ConnoRSM，van Holst Pellekaan NG，et al． Reduced accumulation of specific microRNAs in colorectal neoplasia［J]. Mol CanceRRes，2003，1(12):882-891. [11] [11］ Jun L，Gad G，Eric AM，et al． MicroRNA expression profiles classify human cancers［J]. Nature，2005，435(9):834-838. [12] [12］ Shilpi A，Aarati RR，Nhan LT，et al． MicroRNA-328 is associated with(non-small) cell lung cancer(NSCLC) brain metastasis and mediates NSCLC migration［J]. Int J Cancer，2011，129 (11):2621-2631. [13] [13］ Cui F，Li X，Zhu X，et al． MiR-125b Inhibits tumoRgrowth and promotes apoptosis of cervical cancer cells by targeting phosphoinositide 3-kinase catalytic subunit delta［J]. Cell Physiol Biochem，2012 30(5):1310-1318. [14] [14］ Calin GA，Sevignani C，Dumitru CD，et al． Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers［J]. Proc Natl Acad Sci USA，2004，101(9):2999-3004. [15] [15］ He H，Jazdzewski K，Li W，et al． The role of microRNA genes in papillary thyroid carcinoma［J]. Proc Natl Acad Sci USA，2005， 102(52):19075-19080. [16] [16］ Pallante P，Visone R，Ferracin M，et al． MicroRNA deregulation in human thyroid papillary carcinomas［J]. EndocRRelat Cancer， 2006，13(2):497-508. [17] [17］ Visone R，Russo L，Pallante P，et al． MicroRNAs(miR)-221 and miR-222，both overexpressed in human thyroid papillary carcinomas，regulate p27Kip1 protein levels and cell cycle［J]. EndocRRelat Cancer，2007，14(3):791-798. [18] [18］ Chen YT，Kitabayashi N，Zhou XK，et al． MicroRNA analysis as a potential diagnostic tool foRpapillary thyroid carcinoma［J]. Mod Pathol，2008，21(9):1139-1146. [19] [19］ Chou CK，Chen RF，Chou FF，et al． MiR-146b is highly expressed in adult papillary thyroid carcinomas with high risk features including extrathyroidal invasion and the BRAF (V600E) mutation［J]. Thyroid，2010，20(5):489-494. [20] [20］ WebeRF，Teresi RE，Broelsch CE，et al． A limited set of human MicroRNA is deregulated in folliculaRthyroid carcinoma［J]. J Clin Endocrinol Metab，2006，91(9):3584-3591. [21] [21］ Nikiforova MN，Tseng GC，Steward D，et al． MicroRNA expression profiling of thyroid tumors:biological significance and diagnostic utility［J]. J Clin Endocrinol Metab，2008，93(5):1600-1608. [22] [22］ DettmeRM，VogetsedeRA，Durso MB． MicroRNA Expression Array Identifies Novel Diagnostic Markers for Conventional and Oncocytic FolliculaRThyroid Carcinomas［J]. J Clin Endocrinol Metab，2013，98(1):E1-E7. [23] [23］ Visone R，Pallante P，Vecchione A，et al． Specific microRNAs are downregulated in human thyroid anaplastic carcinomas ［J]. Oncogene，2007，26(54):7590-7595. [24] [24］ Takakura S，Mitsutake N，Nakashima M，et al． Oncogenic role of miR-17-92 clusteRin anaplastic thyroid canceRcells［J]. Cancer Sci，2008，9(6):1147-1154． -
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