• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

内质网应激与自噬信号通路研究进展

宋乐乐 蒋琛琛

引用本文:
Citation:

内质网应激与自噬信号通路研究进展

    作者简介: 宋乐乐(1987-),女,硕士研究生.
    通讯作者: 蒋琛琛, chenchen_jiang@yahoo.com.cn
  • 基金项目:

    国家自然科学基金资助项目(81000992,81072207)

    安 徽省高校省级自然科学研究重点项目(KJ2012A202)

    安徽省自然科学基金资助项目(090413135)

Progress in the endoplasmic reticulum stress and autophagy signaling pathway

    Corresponding author: Jiang Chenchen Proofreading, chenchen_jiang@yahoo.com.cn
  • Fund Project: Project supported by the National Natural Science Fund (8100099281072207) the Anhui Provincial Natural Science Research Project (KJ2012A202) the natural science foundation of Anhui province (090413135)

  • 摘要: 真核细胞通过凋亡途径以应对内质网中未折叠蛋白的累积。目前,有数据证明内质网应激也是自噬的诱导因素,真核细胞循环利用大分子和细胞器,自噬平衡内质网应激诱导的内质网膨胀,促使细胞存活。
  • [2] Schroder M,Sutcliffe L.Consequences of stress in the secretory pathway:the ER stress response and its role in the metabolic syndrome [J].Methods Mol Biol,2010,648:43-62.
    [2] Eizirik DL,Cardozo AK,Cnop M.The role for endoplasmic reticulum stress in diabetes mellitus[J].Endocr Rev,2008,29(1):42-61.
    [3] Wang HQ,Takahashi R.Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease[J].Antioxid Redox Signal,2007,9(5):553-561.
    [5] Belmont PJ,Chen WJ,Thuerauf DJ,et al.Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response [J].J Mol Cell Cardiol,2012,52(5):1716-1782.
    [6] Dalton LE,Clarke HJ,Knight J,et al.The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma [J].Br J Cancer,2013,108(6):1340-1347.
    [7] Martin-Perez R,Niwa M,Lopez-Rivas A.ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2 [J].Apoptosis,2012,17(4):349-363.
    [8] Hirakawa T,Yamaguchi H,Yokose N,et al.Importance of maintaining the relative dose intensity of CHOP-like regimens combined with rituximab in patients with diffuse large B-cell lymphoma [J].Ann Hematol,2010,89(9):897-904.
    [9] Schneider P,Tschopp J.Apoptosis induced by death receptors[J].Pharm Acta Helv,2000,74(2/3):281-286.
    [10] Nishitoh H.CHOP is a multifunctional transcription factor in the ER stress response [J].J Biochem,2011,151(3):217-219.
    [11] Roberson EC,Tully JE,Guala AS,et al.Influenza induces endoplasmic reticulum stress,caspase-12-dependent apoptosis,and c-Jun N-terminal kinase-mediated transforming growth factor- release in lung epithelial cells[J].Am J Respir Cell Mol Biol,2012,46(5):573-581.
    [12] Xu X,Liu T,Zhang A,et al.Reactive oxygen species-triggered trophoblast apoptosis is initiated by endoplasmic reticulum stress via activation of caspase-12,CHOP,and the JNK pathway in Toxoplasma gondii infection in mice [J].Infect Immun,2012,80(6):2121-2132.
    [13] Nakatsumi H,Yonehara S.Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells [J].J Biol Chem,2010,285(33):25418-28425.
    [14] Gardner BM,Walter P.Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response [J].Science,2011,333(6051):1891-1894.
    [15] Lee H,Noh JY,Oh Y,et al.IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux [J].Hum Mol Genet,2011,21(1):101-104.
    [16] Zheng QY,Li PP,Jin FS,et al.Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells [J].Cell Signal,2012,25(1):206-213.
    [17] Hirata H,Lopes GS,Jurkiewicz A,et al.Bcl-2 modulates endoplasmic reticulum and mitochondrial calcium stores in PC12 cells [J].Neurochem Res,2012,37(2):238-243.
    [18] Bhavya BC,Indira D,Seervi M,et al.Endoplasmic reticulum-targeted Bcl-2 inhibitable mitochondrial fragmentation initiates ER stress-induced cell death [J].Adv Exp Med Biol,2012,749(1):83-95.
    [19] Ryu SW,Choi K,Yoon J,et al.Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2 and Drp1-dependent manner [J].J Cell Physiol,2012,227(8):3027-3035.
    [20] Soo KY,Atkin JD,Farg M,et al.Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis [J].PLoS One,2012,7(4):e35413.
    [21] Choi JH,Lee JY,Choi AY,et al.Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cgamma1- and Ca2+-dependent pathway in mouse Neuro-2a neuroblastoma cells [J].Apoptosis,2012,17(12):1340-1358.
    [22] Sabatini DM.mTOR and cancer:insights into a complex relationship[J].Nat Rev Cancer,2006,6(9):729-734.
    [23] Lum JJ,Bauer DE,Kong M,et al.Growth factor regulation of autophagy and cell survival in the absence of apoptosis[J].Cell,2005,120(2):237-248.
    [24] Sarbassov DD,Ali SM,Sabatini DM.Growing roles for the mTOR pathway[J].Curr Opin Cell Biol,2005,17(6):596-603.
    [25] Momoi T.Conformational diseases and ER stress-mediated cell death:apoptotic cell death and autophagic cell death[J].Curr Mol Med,2006,6(1):111-118.
    [26] Kouroku Y,Fujita E,Tanida I,et al.ER stress(PERK/eIF2- phosphorylation) mediates the polyglutamine-induced LC3 conversion,an essential step for autophagy formation[J].Cell Death Differ,2007,14(2):230-239.
    [27] Fujita E,Kouroku Y,Isoai A,et al.Two endoplasmic reticulum-associated degradation(ERAD) systems for the novel variant of the mutant dysferlin:ubiquitin/proteasome ERAD(Ⅰ) and autophagy/lysosome ERAD(Ⅱ) [J].Hum Mol Genet,2007,16(6):618-629.
    [28] Rutkowski DT,Kaufman RJ.All roads lead to ATF4[J].Dev Cell,2003,4(4):442-444.
    [29] Kanno H,Ozawa H,Sekiguchi A,et al.Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death [J].Science,2009,33(2):143-148.
    [30] Yousefi S,Perozzo R,Schmid I,et al.Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis[J].Nat Cell Biol,2006,8(10):1124-1132.
    [31] Hoyer-Hansen M,Bastholm L,Szyniarowski P,et al.Control of macroautophagy by calcium,calmodulin-dependent kinase kinase-,and Bcl-2[J].Mol Cell,2007,25(2):193-205.
    [32] Criollo A,Maiuri MC,Tasdemir E,et al.Regulation of autophagy by the inositol trisphosphate receptor[J].Cell Death Differ,2007,14(5):1029-1039.
    [33] Madden DT,Egger L,Bredesen DE.A calpain-like protease inhibits autophagic cell death[J].Autophagy,2007,3(5):519-522.
    [34] Zhong JT,Xu Y,Yi HW,et al.The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells [J].Cancer Lett,2012,323(2):180-187.
    [35] Bernales S,McDonald KL,Walter P.Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response[J].PLoS Biol,2006,4(12):E423.
  • [1] 唐样王宜君王璐瑶宋雪 . 通过抑制氧化应激损伤治疗炎症性肠病的前景展望. 蚌埠医学院学报, 2024, 49(1): 137-141. doi: 10.13898/j.cnki.issn.1000-2200.2024.01.031
    [2] 何小燕钱中清 . 自噬与巨噬细胞功能的关系研究进展. 蚌埠医学院学报, 2017, 42(9): 1288-1290. doi: 10.13898/j.cnki.issn.1000-2200.2017.09.043
    [3] 孔祥歆刘卉芳陈凤玲 . 自噬在巨噬细胞极化中的作用研究进展. 蚌埠医学院学报, 2018, 43(3): 415-417. doi: 10.13898/j.cnki.issn.1000-2200.2018.03.041
    [4] 浦龙健刘浩蒋琛琛 . 肿瘤多药耐药机制及逆转策略的研究进展. 蚌埠医学院学报, 2014, 38(3): 409-412.
    [5] 杨芬蒋志文 . 内质网应激对肿瘤发展及化疗反应的影响. 蚌埠医学院学报, 2009, 34(5): 457-459.
    [6] 刘海防谢青 . 内质网应激在肝细胞凋亡中的意义. 蚌埠医学院学报, 2010, 35(8): 768-770.
    [7] 胡曦沈敏燕朱静张光亚毛子明陈凤玲 . 黄连碱对人脐静脉内皮细胞内质网应激的影响. 蚌埠医学院学报, 2019, 44(12): 1577-1581. doi: 10.13898/j.cnki.issn.1000-2200.2019.12.001
    [8] 陶卉段晓宇刘筱张燕田晓芬吴群英于杨 . Nrf2/HO-1通路通过调控内质网应激改善小鼠心肌细胞缺氧/复氧损伤的作用研究. 蚌埠医学院学报, 2023, 48(3): 296-300. doi: 10.13898/j.cnki.issn.1000-2200.2023.03.004
    [9] 张继千刘学胜王纯辉 . 罗哌卡因对HeLa细胞自噬及自噬溶酶体的影响. 蚌埠医学院学报, 2017, 42(12): 1581-1584. doi: 10.13898/j.cnki.issn.1000-2200.2017.12.003
    [10] 冯琛朱超余定玥刘蕴霞宋早智王庆康钱军 . 三阴性乳腺癌的上皮间质转化及自噬特性差异的研究. 蚌埠医学院学报, 2019, 44(11): 1445-1448, 1452. doi: 10.13898/j.cnki.issn.1000-2200.2019.11.003
    [11] 李娟徐家新王春邵晨周路路 . 利拉鲁肽通过AMPK/mTOR信号通路诱导自噬改善肝脂肪变性. 蚌埠医学院学报, 2022, 47(10): 1336-1341. doi: 10.13898/j.cnki.issn.1000-2200.2022.10.002
    [12] 吴宣宣张俊丽商玲燕善军武文娟 . 低分子质量肝素联合顺铂对肝癌细胞自噬的影响. 蚌埠医学院学报, 2023, 48(4): 426-431. doi: 10.13898/j.cnki.issn.1000-2200.2023.04.002
    [13] 朱晓骏孙学华刘顺庆高月求 . 人自噬相关基因LC3B真核表达载体的构建及鉴定. 蚌埠医学院学报, 2012, 36(2): 145-148.
    [14] 沈敏燕胡曦朱静张光亚毛子明陈凤玲 . 黄连碱促进肝细胞自噬及胆固醇外流改善脂肪肝的脂质蓄积. 蚌埠医学院学报, 2021, 46(4): 421-424, 430. doi: 10.13898/j.cnki.issn.1000-2200.2021.04.001
    [15] 宋涛官泽宇徐超朱二畅蔡瑶卢冉余朝文 . 槲皮素对过氧化氢诱导的人脐静脉内皮细胞AKT/mTOR信号通路及自噬的影响. 蚌埠医学院学报, 2023, 48(2): 141-144. doi: 10.13898/j.cnki.issn.1000-2200.2023.02.001
    [16] 季静张晔陆晓红徐锋詹惠英 . 顺铂通过增加HeLa人宫颈癌细胞中Nrf2入核促进细胞自噬和凋亡. 蚌埠医学院学报, 2023, 48(3): 301-305. doi: 10.13898/j.cnki.issn.1000-2200.2023.03.005
    [17] 王康恒王毅 . 基于mTOR/ULK1/ATG13通路探讨绞股蓝总苷对抑郁症大鼠海马神经元过度自噬的保护作用. 蚌埠医学院学报, 2023, 48(10): 1333-1338. doi: 10.13898/j.cnki.issn.1000-2200.2023.10.002
    [18] 李小荣鲜维谭鑫陈永锋唐碧张恒康品方王洪巨 . 线粒体ALDH2通过调控自噬对缺氧性肺动脉高压的保护机制研究. 蚌埠医学院学报, 2023, 48(1): 66-71. doi: 10.13898/j.cnki.issn.1000-2200.2023.01.013
    [19] 雷思雨陈曼曼陈斌李玉云 . 细胞自噬与肿瘤微环境的关系研究进展. 蚌埠医学院学报, 2018, 43(7): 979-981. doi: 10.13898/j.cnki.issn.1000-2200.2018.07.043
    [20] 高峰 . 食管癌研究现状综述. 蚌埠医学院学报, 2010, 35(6): 645-648.
  • 加载中
计量
  • 文章访问数:  4588
  • HTML全文浏览量:  709
  • PDF下载量:  570
  • 被引次数: 0
出版历程
  • 收稿日期:  2012-09-03
  • 刊出日期:  2014-05-15

内质网应激与自噬信号通路研究进展

    通讯作者: 蒋琛琛, chenchen_jiang@yahoo.com.cn
    作者简介: 宋乐乐(1987-),女,硕士研究生.
  • 1. 1. 蚌埠医学院第一附属医院 药剂科,安徽 蚌埠 233004;
  • 2.  2. 蚌埠医学院 药学系,安徽省生化药物工程技术研 究中心,安徽 蚌埠 233030
基金项目:  国家自然科学基金资助项目(81000992,81072207)安 徽省高校省级自然科学研究重点项目(KJ2012A202) 安徽省自然科学基金资助项目(090413135)

摘要: 真核细胞通过凋亡途径以应对内质网中未折叠蛋白的累积。目前,有数据证明内质网应激也是自噬的诱导因素,真核细胞循环利用大分子和细胞器,自噬平衡内质网应激诱导的内质网膨胀,促使细胞存活。

English Abstract

参考文献 (34)

目录

    /

    返回文章
    返回