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非综合症性唇腭裂的病因研究进展

张艳萍 柴继侠

引用本文:
Citation:

非综合症性唇腭裂的病因研究进展

    作者简介: 张艳萍(1978-),女,副主任医师.
  • 基金项目:

    山东省自然科学基金资助项目(2009ZRA01193)

Progress in study on cause of non syndromic cleft lip and cleft palate

  • Fund Project: The natural science foundation of Shandong province (2009ZRA01193)

  • 摘要: 先天性唇腭裂为人类最常见的出生后颅面缺陷和先天畸形之一,可单独发生或伴发与染色体或基因表达异常及外源致畸因素导致的发育缺陷综合征.
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    [16] Kuriyama M,Udagawa A,Yoshimoto S,et al.DNA methylation changes during cleft palate formation induced by retinoic acid in mice[J].Cleft Palate Craniofac J,2008,45(5):545-551.
    [17] Honein MA,Rasmussen SA,Reefhuis J,et al.Maternal smoking and environmental tobacco smoke exposure and the risk of orofacial clefts[J].Epidemiology,2007,18(2):226-233.
    [18] Grewal J,Carmichael SL,Ma C,et al.Maternal periconceptional smoking and alcohol consumption and risk for select congenital anomalies[J].Birth Defects Res A Clin Mol Teratol,2008,82(7):519-526.
    [19] Juriloff DM,Harris MJ.Mouse genetic models of cleft lip with or without cleft palate[J].Birth Defects Res A Clin Mol Teratol,2008,82(2):63-77.
    [20] Scharer CD,McCabe CD,Ali-Seyed M,et al.Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells[J].Cancer Res,2009,69(2):709-717.
    [21] Clark SJ,Harrison J,Paul CL,et al.High sensitivity mapping of methylated cytosines[J].Nucl Acids Res,1994,22(15):2990-2997.
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    [23] Shi M,Christensen K,Weinberg CR,et al.Orofacial cleft risk is increased with maternal smoking and specific detoxificationgene variants[J].Am J Hum Genet,2007,80(1):76-90.
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    [25] Boyles AL,Wilcox AJ,Taylor JA,et al.Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A:a pathway-wide association study[J].Genet Epidemiol,2009,33(3):247-255.
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出版历程
  • 收稿日期:  2012-08-04
  • 刊出日期:  2014-05-15

非综合症性唇腭裂的病因研究进展

    作者简介: 张艳萍(1978-),女,副主任医师.
  • 1. 1. 山东省计划生育科学技术研究所,优生技术重点实验室,山东济南250002;
  • 2.  2. 蚌埠医学院组织胚胎学教研室,安徽蚌埠233030
基金项目:  山东省自然科学基金资助项目(2009ZRA01193)

摘要: 先天性唇腭裂为人类最常见的出生后颅面缺陷和先天畸形之一,可单独发生或伴发与染色体或基因表达异常及外源致畸因素导致的发育缺陷综合征.

English Abstract

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