乳腺癌扩增基因-1在胃癌中的表达及其临床意义

袁圆

乳腺癌扩增基因-1在胃癌中的表达及其临床意义

袁圆

蚌埠医学院解剖学教研室, 安徽蚌埠 233030

作者简介: 袁圆(1984-), 女, 硕士, 助教.

基金项目:
博士研究生科研启动基金(2010BR030)

安徽省自然科学基金资助项目(11040606M163)
中图分类号: R735.2

Expression of amplified in breast cancer 1 gene in gastric carcinoma and its clinical significance

YUAN Yuan

Department of Anatomy, Bengbu Medical College, Bengbu Anhui 233030, China
CLC number: R735.2

摘要: 目的: 探讨乳腺癌扩增基因-1(AIB1)在胃癌组织中的表达及其临床意义.方法: 采用免疫组织化学法,检测88例胃癌组织和85例癌旁组织中AIB1的表达情况,并分析其与各临床病理特征之间的关系.结果: 88例胃癌组织中AIB1的阳性表达率为75.0%,85例癌旁组织中AIB1的阳性表达率为7.1%,差异有统计学意义(P<0.01).AIB1的阳性表达在淋巴结转移和临床分期方面差异均有统计学意义(P<0.05),而在患者年龄、性别、肿瘤大小、分化程度和浸润深度间差异均无统计学意义(P>0.05).结论: AIB1蛋白在胃癌组织中呈异常高表达,可能与胃癌的发生、发展以及浸润转移有关.
- 胃肿瘤 /
- 乳腺癌扩增基因-1 /
- 免疫组织化学
Abstract: Objective: To investigate the expression of amplified in breast cancer 1(AIB1) in gastric carcinoma and its clinical significance.Methods: The expressions of AIB1 in gastric carcinoma tissue(n=88) and Para-cancerous tissue(n=85) were detected by immunohistochemical method.The relationship between AIB1 expression and clinicopathologic features was analyzed.Results: The positive rates of AIB1 expression in 88 gastric carcinoma samples and 85 Para-cancerous samples were 75.0% and 7.1%,respectively,the difference of which was statistically significant(P<0.01).The differences of positive AIB1 expression in lymph node metastasis and clinical stages were statistically significant(P<0.01),but the differences of AIB1 expression in sex,age,size of tumor,degree of differentiation and depth of tumor infiltration were not statistically significant(P>0.05).Conclusions: The high expression of AIB1 protein in gastric carcinoma tissue may be associated with the occurrence,development and metastasis of gastric cancer.
- gastric neoplasm /
- amplified in breast cancer 1 /
- immunohistochemistry

[1]	Kuang SQ,Liao L,Wang S,et al.Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen induced mammary tumor genesis[J].Cancer Res,2005,65(17):7993-8002.
[2]	Anzick SL,Kononen J,Walker RL,et al.AIB1,a steroid receptor coactivator amplified in breast and ovarian cancer[J].Science,1997,277(5328):965-968.
[3]	Henke RT,Haddad BR,Kim SE,et al.Over expression of the nuclear receptor coactivator AIB1 during progression of pancreatic adeno carcinoma[J].Clin Cancer Res,2004,10(18 Pt 1):6134-6142.
[4]	李庆霞,潘海燕,刑雅军,等.AIB1蛋白在乳腺癌中的表达及在内分泌治疗中的临床意义[J].中国肿瘤,2012,21(6):453-457.
[5]	List HJ,Reiter R,Singh B,et al.Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue[J].Breast Cancer Res Treat,2001,68(1):21-28.
[6]	Lahusen T,Henke RT,Kagan BL,et al.The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer[J].Breast Cancer Res Treat,2009,116(2):225-237.
[7]	朱益平,刘银华,盛莉莉,等.AIB1蛋白在卵巢肿瘤中的表达及意义[J].皖南医学院学报,2012,31(6):435-437.
[8]	Blamer NN,Richer TK,Spoelstra NS,et al.Steroid receptor coactivator AIB1 in endometrial carcinoma,hyperplasia and normal endometrial correlation with clinic pathologic parameters and biomarkers[J].Modern Pathology,2006,19(12):1593-1605.
[9]	Hirai Y,Utsugi K,Takeshima N,et al.Putative gene loci associated with carcinogenesis and metastasis of end cervical Aden carcinomas of uterus determined by conventional and array-based CGH[J].Am J Obste Gynecol,2004,191(4):1173-1182.
[10]	韩肖燕,陈悦,侯敏敏.上皮性卵巢癌AIB1蛋白表达水平及与雌、孕激素受体表达的相关性研究[J].实用肿瘤杂志,2009,24(4):341-344.
[11]	Zhou HJ,Yan J,Luo WP,et al.SRC-3 is required for prostate cancer cell proliferation and survival[J].Cancer Res,2005,65(17):7976 -7983.
[12]	Xu FP,Xie D,Wen JM,et al.SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinoma[J].Cancer Lett,2007,245(1):69-74.
[13]	Hel R,Liu MZ,Li BK,et al.Overexpression of AIB1 predicts resistance to chemoradiotherapy and poorprognosis in patients with primary esophageal squamous cell carcinoma[J].Cancer Sci,2009,100(9):1591-1596.
[14]	Xie D,Sham JS,Zeng WF,et al.Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma[J].Hum Pathos,2005,36(7):777-783.
[15]	Grivas PD,Tzelepi V,Sotiropoulou-Bonikou G,et al.Estrogen receptor α/β,AIB1 and TIF2 is colorectal carcinogenesis:Do coregulators have prognostic significance?[J].Int J Colorectal Dis,2009,24(6):613-622.
[16]	Liu MZ,Xie D,Mai SJ,et al.Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage[J].Am J Clin Pathol,2008,129(5):728-734.
[17]	Luo JH,Xie D,Liu MZ,et al.Protein expression and amplification of AIB1 in human urothelial carcinoma of the bladder and over expression of AIB1 is a new independent prognostic marker of patient survival[J].Into J Cancer,2008,122(11):2554-2561.
[18]	He LR,Zhao HY,Li BK,et al.Over expression of AIB1 negatively affects surgically resented non-small-cell lung cancer patients[J].Ann Oncol,2010,21(8):1675-1681.
[19]	Yan J,Erdem H,Li R,et al.Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression[J].Cancer Res,2008,68(13):5460-5468.

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乳腺癌扩增基因-1在胃癌中的表达及其临床意义

作者简介: 袁圆(1984-), 女, 硕士, 助教.

Expression of amplified in breast cancer 1 gene in gastric carcinoma and its clinical significance

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乳腺癌扩增基因-1在胃癌中的表达及其临床意义

作者简介: 袁圆(1984-), 女, 硕士, 助教.

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Expression of amplified in breast cancer 1 gene in gastric carcinoma and its clinical significance

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乳腺癌扩增基因-1在胃癌中的表达及其临床意义

作者简介: 袁 圆(1984-), 女, 硕士, 助教.

Expression of amplified in breast cancer 1 gene in gastric carcinoma and its clinical significance

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乳腺癌扩增基因-1在胃癌中的表达及其临床意义

作者简介: 袁 圆(1984-), 女, 硕士, 助教.

English Abstract

Expression of amplified in breast cancer 1 gene in gastric carcinoma and its clinical significance

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目录

作者简介: 袁圆(1984-), 女, 硕士, 助教.

作者简介: 袁圆(1984-), 女, 硕士, 助教.