联合检测血清胃蛋白酶原、胃泌素-17在萎缩性胃炎及胃癌筛查中的价值
The value of the joint detection of serum Pepsinogen and Gastrin-17 in the screening of atrophic gastritis and gastric cancer
-
摘要: 目的: 通过测定不同胃疾病的血清胃蛋白酶原(PG)Ⅰ、PGⅡ水平和二者比值(PGR)以及胃泌素-17(G-17)水平,探讨PG、G-17作为萎缩性胃炎和胃癌筛查指标的价值.方法: 选取2012年8月至2013年10月行胃镜检查的门诊及住院患者共278例,根据胃镜及病理结果分为4组,包括非萎缩性胃炎组105例,萎缩性胃炎组42例,胃癌组64例和胃溃疡组67例.用酶联免疫吸附试验定量检测每例血清PGⅠ、PGⅡ和G-17水平,并计算PGR值.结果: 萎缩性胃炎组及胃癌组PGⅠ水平和PGR均较非萎缩性胃炎组明显降低(P< 0.01),G-17水平明显升高(P< 0.01);胃癌组PGⅠ水平和PGR均较萎缩性胃炎组明显降低(P< 0.01),G-17水平差异无统计学意义(P >0.05).胃癌组中,进展期胃癌血清PGⅠ水平、PGR明显低于早期胃癌(P< 0.01),G-17水平差异无统计学意义(P >0.05).结论: 血清PGⅠ、PGR降低及G-17升高提示了萎缩性胃炎和胃癌的高危风险,联合检测血清PG和G-17可以作为胃萎缩及胃癌的筛查手段,为是否需行进一步胃镜检查提供积极参考.Abstract: Objective: To investigate the value of the levels of serum Pepsinogen(PG) and Gastrin-17(G-17) in the screening of atrophic gastritis and gastric cancer.Methods: Two hundred and seventy-eight patients undergone gastroscopy from August 2012 to October 2013 were divided into the chronic non-atrophic gastritis group(105 cases),atrophic gastritis group(42 cases),gastric cancer(64 cases) and gastric ulcer group(67 cases) according to the results of gastroscopy and histopathology.The levels of serum PGⅠ,PGⅡand G-17 in all case were measured by enzyme-linked immunosorbent assay(ELISA),and the PGR(ratio of PGⅠto PGⅡ) was calculated.Results: Compared with the chronic non-atrophic gastritis group,the PGⅠleveland PGR decreased significantly in atrophic gastritis and gastric cancer groups(P< 0.01),but for G-17,it increased significantly in the two groups(P< 0.01).Compared with the atrophic gastritis group,the PGⅠ level and PGR in gastric cancer group decreased significantly(P< 0.01),the difference of the G-17 level between the atrophic gastritis and gastric cancer groups was not statistically significant(P >0.05).The PGⅠ level and PGR in advanced gastric cancer patients were significantly lower than those in early gastric cancer patients(P< 0.01),while the difference of G-17 level between them was not statistically significant(P >0.05).Conclusions: The PGⅠ level and PGR decreasing and G-17 level increasing suggest the possible of atrophic gastritis and gastric cancer.The joint detection of serum Pepsinogen and Gastrin-17 is an important means in the screening of atrophic gastritis and gastric cancer,which can provide a positive reference for further gastroscopy.
-
Key words:
- atrophic gastritis /
- stomach neoplasm /
- pepsinogen /
- gastrin
-
[1] Takahashi T,Saikawa Y,Kitagawa Y.Gastric cancer:current status of diagnosis and treatment[J].Cancers(Basel),2013,5(1):48-63. [2] Kikuchi R,Abe Y,Iijima K,et al.Low serum levels of pepsinogen and gastrin 17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer[J].Tohoku J Exp Med,2011,223(1):35-44. [3] Hosseini M,Amoueian S,Attaranzadeh A,et al.Serum gastrin 17,pepsinogen Ⅰ and pepsinogen Ⅱ in atrophic gastritis patients living in North-East of Iran[J].J Res Med Sci,2013,18(3):225-229. [4] Shafaghi A,Mansour-Ghanaei F,Joukar F,et al.Serum gastrin and the pepsinogen Ⅰ/Ⅱ ratio as markers for diagnosis of premalignant gastric lesions[J].Asian Pac J Cancer Prev,2013,14(6):3931-3936. [5] Sun LP,Gong YH,Wang L,et al.Serum pepsinogen levels and their influencing factors:a population-based study in 6 990 Chinese from North China[J].World J Gastroenterol,2007,13(48):6562-6567. [6] 曹雪源,贾志芳,马洪喜,等.血清抗幽门螺杆菌抗体、胃蛋白酶原水平与胃癌发病的相关性分析[J].中国实验诊断学,2012,16(6):1026-1028. [7] 毛秋卉,刘文佳,张学俭,等.血清胃蛋白酶原和胃泌素-17在胃癌筛选中的作用[J].国际消化病杂志,2012,32(2):85-87. [8] 中华医学会消化病学分会.中国慢性胃炎共识意见[J].中华消化杂志,2013,33(1):5-16. [9] Dixon MF,Genta RM,Yardley JH,et al.Classification and grading of gastritis.The updated Sydney System.International Workshop on the Histo-Pathology of Gastritis,Houston 1994[J].Am J Surg Pathol,1996,20(10):1161-1181.[10] Correa P.Human gastric carcinogenesis:Multistep and multifactorial process[J].CancerRes,1992,52(24):6735-6742. [10] He CY,Sun LP,Gong YH,et al.Serum pepsinogen Ⅱ:a neglected but useful biomarker to differentiate between diseased and normal stomachs[J].J Gastroenterol Hepatol,2011,26(6):1039-1046. [11] 陈智周,范振符.胃蛋白酶原Ⅰ、Ⅱ在早期胃癌普查中的意义[J].中华肿瘤杂志,2002,24(1):1-3. [12] Fock KM,Talley N,Moayyedi P,et al.Asia-Pacific Gastric Cancer Consensus Conference.Asia-Pacific consensus guidelines on gastric cancer prevention[J].J Gastroenterol Hepatol,2008,23(3):351-365. [13] Copps J,Murphy RF,Lovas S.The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers[J].Protein Pept Lett,2009,16(12):1504-1518. [14] 曹勤,冉志华,萧树东.检测血清胃蛋白酶原和胃泌素-17诊断胃癌的临床价值[J].胃肠病学和肝病学杂志,2007,16(4):361-364. [15] Sipponen P,Ranta P,Helske T,et al.Serum levels of amidated gastrin-17 and pepsinogen Ⅰ in atrophic gastritis:an observational case-control study[J].Scand J Gastroenterol,2002,37(7):785-791. [16] 马颖杰,王惠吉,鲍晓厉.血清胃蛋白酶原与胃溃疡及胃癌[J].中国医刊,2008,43(12):46-48. -
点击查看大图
计量
- 文章访问数: 3669
- HTML全文浏览量: 396
- PDF下载量: 17
- 被引次数: 0
下载:
