肾上腺髓质素在肺癌患者中的表达及作用

温雪萍; 李艳; 王忠慧; 彭清; 颜志军; 丁梅芬; 黄绍光; 赵家美; 苏宝山

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肾上腺髓质素在肺癌患者中的表达及作用

温雪萍 , 李艳 , 王忠慧 , 彭清 , 颜志军 , 丁梅芬 , 黄绍光 , 赵家美 , 苏宝山

文章导航 > 蚌埠医学院学报 > 2009, 34 > 6: (473-476)

引用本文:

Citation:

肾上腺髓质素在肺癌患者中的表达及作用

1. 上海瑞金医院集团闵行医院呼吸内科, 上海 201100;
2. 上海交通大学附属瑞金医院肺科, 上海 200025;
3. 上海市胸科医院肺科, 上海 200030;
4. 西安交通大学第二医院病理科, 陕西西安 710004

作者简介: 温雪萍(1955-),女,主任医师.

基金项目:
上海市闵行区自然科学研究资助项目(04-81)
中图分类号: R734.2

Expression and role of adrenomedullin in human lung cancer

1. Department of Respirtory Disease, Minhang Hospital of Ruijin Hospital Group, Shanghai 201100;
2. Department of Pulmonology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025;
3. Department of Pulmonology, Shanghai Chest Hospital, Shanghai 200030;
4. Department of Oncology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Shangxi Xi'an 710004, China
CLC number: R734.2

摘要: 目的:探讨肾上腺髓质素(adrenomedullin,ADM)在肺癌患者的表达及其与肺癌临床生物学特征的相关性。方法:采用免疫组织化学和放免法检测肺癌组织及血浆中ADM的表达情况,并回顾性分析ADM基因表达与肺癌的临床生物学特征的关系。结果:肺癌组织的ADM蛋白表达明显高于癌旁组织及正常肺组织(P<0.01),而癌旁组织的ADM阳性表达率与正常肺组织差异无统计学意义(P>0.05)。肺癌组织中ADM蛋白的表达与肺癌分化程度有一定关系(P<0.05),与年龄、病理类型和TNM分期无明显关系(P>0.05)。肺癌组血浆中ADM含量均高于非肺癌组和健康对照组(P<0.05和P<0.01),且血浆中ADM的表达与TNM分期有一定关系(P<0.05),与病理类型无明显关系(P>0.05)。结论:肺癌患者中ADM表达明显增强,其表达水平与肺癌分化程度显著相关,ADM基因在肺癌的发生、发展中可能起重要作用。
- 肺肿瘤 /
- 肾上腺髓质素
Abstract: Objective: To investigate the expression of adrenomedullin(ADM) in human lung cancer and to evaluate its clinical significance.Methods: Immunohistochemical staining was performed to examine the expression of ADM in lung cancer,radioimmunoassay was applied to determine the concentration of ADM in the plasm of patients and controls,and the relationship was retrospectively analyzed between the expression of ADM in lung cancer and the clinicobiological features.Results: The expression of ADM in lung cancer was significantly higher than those in adjacent tissues and normal tissues(P<0.01),and the positive rate of ADM protein in adjacent tissues and that in the normal ones was no significant difference(P>0.05).There was a significant relationship between the expression of ADM and the grade of lung cancer(P<0.05 and P<0.01),and there were no relationships between the expression of ADM and age,histological type and TNM stage(P>0.05).The expression of ADM in the plasm of lung cancer group was significantly higher than those in the plasm of non-lung cancer group and healthy control group(P<0.05).There was a significant relationship between the expression of ADM in the plasm and TNM stage(P<0.05),and there was no relationships between the expression of ADM in the plasm and histological type(P>0.05).Conclusions: The expression of ADM significantly increased in lung cancer and was associated with grade.ADM may play an important role in the lung cancer.
- lung noeplasms /
- adrenomedullin

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肾上腺髓质素在肺癌患者中的表达及作用

作者简介: 温雪萍(1955-),女,主任医师.

1. 上海瑞金医院集团闵行医院呼吸内科, 上海 201100;
2. 上海交通大学附属瑞金医院肺科, 上海 200025;
3. 上海市胸科医院肺科, 上海 200030;
4. 西安交通大学第二医院病理科, 陕西西安 710004

收稿日期: 2008-11-04

基金项目: 上海市闵行区自然科学研究资助项目(04-81)

关键词:

肺肿瘤 /
肾上腺髓质素

摘要: 目的:探讨肾上腺髓质素(adrenomedullin,ADM)在肺癌患者的表达及其与肺癌临床生物学特征的相关性。方法:采用免疫组织化学和放免法检测肺癌组织及血浆中ADM的表达情况,并回顾性分析ADM基因表达与肺癌的临床生物学特征的关系。结果:肺癌组织的ADM蛋白表达明显高于癌旁组织及正常肺组织(P<0.01),而癌旁组织的ADM阳性表达率与正常肺组织差异无统计学意义(P>0.05)。肺癌组织中ADM蛋白的表达与肺癌分化程度有一定关系(P<0.05),与年龄、病理类型和TNM分期无明显关系(P>0.05)。肺癌组血浆中ADM含量均高于非肺癌组和健康对照组(P<0.05和P<0.01),且血浆中ADM的表达与TNM分期有一定关系(P<0.05),与病理类型无明显关系(P>0.05)。结论:肺癌患者中ADM表达明显增强,其表达水平与肺癌分化程度显著相关,ADM基因在肺癌的发生、发展中可能起重要作用。

English Abstract

Expression and role of adrenomedullin in human lung cancer

1. Department of Respirtory Disease, Minhang Hospital of Ruijin Hospital Group, Shanghai 201100;
2. Department of Pulmonology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025;
3. Department of Pulmonology, Shanghai Chest Hospital, Shanghai 200030;
4. Department of Oncology, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Shangxi Xi'an 710004, China

Received Date: 2008-11-04

Abstract: Objective: To investigate the expression of adrenomedullin(ADM) in human lung cancer and to evaluate its clinical significance.Methods: Immunohistochemical staining was performed to examine the expression of ADM in lung cancer,radioimmunoassay was applied to determine the concentration of ADM in the plasm of patients and controls,and the relationship was retrospectively analyzed between the expression of ADM in lung cancer and the clinicobiological features.Results: The expression of ADM in lung cancer was significantly higher than those in adjacent tissues and normal tissues(P<0.01),and the positive rate of ADM protein in adjacent tissues and that in the normal ones was no significant difference(P>0.05).There was a significant relationship between the expression of ADM and the grade of lung cancer(P<0.05 and P<0.01),and there were no relationships between the expression of ADM and age,histological type and TNM stage(P>0.05).The expression of ADM in the plasm of lung cancer group was significantly higher than those in the plasm of non-lung cancer group and healthy control group(P<0.05).There was a significant relationship between the expression of ADM in the plasm and TNM stage(P<0.05),and there was no relationships between the expression of ADM in the plasm and histological type(P>0.05).Conclusions: The expression of ADM significantly increased in lung cancer and was associated with grade.ADM may play an important role in the lung cancer.