凋亡抑制基因Livin在卵巢上皮性癌组织中的表达及其与PTEN的相关性研究

王玲玲; 席玉玲; 凌斌; 赵卫东; 承泽农

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

凋亡抑制基因Livin在卵巢上皮性癌组织中的表达及其与PTEN的相关性研究

王玲玲 , 席玉玲 , 凌斌 , 赵卫东 , 承泽农

文章导航 > 蚌埠医学院学报 > 2011, 36 > 3: (223-226)

引用本文:

Citation:

凋亡抑制基因Livin在卵巢上皮性癌组织中的表达及其与PTEN的相关性研究

1. 安徽医科大学附属省立医院妇产科, 安徽合肥 230032;
2. 蚌埠医学院第一附属医院妇产科, 安徽蚌埠 233004;
3. 蚌埠医学院病理学教研室, 安徽蚌埠 233030

作者简介: 王玲玲(1977-),女,主治医师,讲师.

中图分类号: R737.71

Relationship of expression of apoptosis inhibitor gene Livin and cancer surppresser gene PTEN in epithelial ovarian carcinoma

1. Department of Obstetrics and Gynecology, Anhui Provinical Hospital, Anhui Medical University, Hefei Anhui 230032;
2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;
3. Department of Pathology, Bengbu Medical College, Bengbu Anhui 233030, China
CLC number: R737.71

摘要: 目的: 探讨Livin和张力蛋白同源10q丢失的磷酸酶基因(phosphatase and tensin hornology deleted on chromosome 10,PTEN)的表达与卵巢上皮性癌的临床病理学特征的关系及其相关性。方法: 采用免疫组织化学EliVision法检测60例卵巢上皮性癌组织、20例良性卵巢上皮性肿瘤及20例正常卵巢组织中Livin及PTEN表达情况。结果: 卵巢上皮性癌中Livin阳性率(80.0%)均明显高于卵巢良性上皮性肿瘤(10.0%)及正常卵巢组织(5.0%)(P<0.01)。卵巢上皮性癌的组织病理学分级间Livin的阳性率差异有统计学意义(P<0.01),而在临床分期及淋巴结转移中差异均无统计学意义(P>0.05)。卵巢上皮性癌中PTEN的阳性率(26.7%)均明显低于卵巢良性上皮性肿瘤(95.0%)及正常卵巢组织(100.0%)(P<0.01);卵巢上皮性癌的临床分期、组织病理学分级及淋巴结有无转移间PTEN的阳性率差异均有统计学意义(P<0.01)。卵巢上皮性癌中Livin的阳性率与PTEN的阳性率呈负相关关系(P<0.01)。结论: Livin的表达上调及PTEN的表达下调在卵巢上皮性癌的发生、分化进展中起重要作用,Livin基因有可能成为治疗卵巢癌的新靶点。
- 卵巢肿瘤 /
- 凋亡抑制基因 /
- 表达 /
- 病理学 /
- 相关性
Abstract: Objective: To study the expression and pathological characteristics of Livin and PTEN proteins in epithelial ovarian carcinoma as well as their inter-relationship. Methods: The Expression of Livin and PTEN in 60 samples of ovarian epithelial carcinoma,20 samples of benign ovarian epithelial tumor and 20 normal ovarian tissues were detected by immunohistochemistry. Results: The Livin protein expression (80.0%) in epithelial ovarian carcinoma tissues was significantly higher than that of benign ovarian epithelial tumors (10.0%) and normal ovarian tissues (5.0%) (P<0.01). The expression of Livin had a positive correlation with the tumor grade,but no statistical correlation with the tumor stage or lymph node metastasis. The positive expression of PTEN protein in epithelial ovarian carcinoma (26.7%) was significantly lower than that in benign ovarian epithelial tumors (95.0%) and normal ovarian tissues (100.0) (P<0.01). The expression of PTEN was negatively related to the tumor stage,tumor grade and lymph node metastasis (P<0.01); the expression of Livin was negatively correlated with the expression of PTEN (P<0.01). Conclusions: Up-regulated expression of Livin and down-regulated expression of PTEN may play an important role in the process of carcinogenesis and differentiation of epithelial ovarian carcinoma. Livin may be useful targets for treatment of ovarian carcinoma.
- ovarian neoplasmas /
- apoptosis inhibitor gene /
- expression /
- pathological /
- correlation

[1]	张小鹏 , 王晓玉 . 整合素与卵巢癌转移的相关性研究进展. 蚌埠医学院学报, 2011, 36(2): 205-208.
[2]	王秀 , 刘真 , 吴晶晶 , 王秀丽 , 乌日娜 . 人附睾蛋白4、CA199、LPA在卵巢癌中的表达及与临床病理特征的相关性. 蚌埠医学院学报, 2021, 46(2): 183-186, 190. doi: 10.13898/j.cnki.issn.1000-2200.2021.02.012
[3]	王捷文 , 赵卫东 , 承泽农 . Ki-67、VEGF在卵巢交界性肿瘤中的表达及其意义. 蚌埠医学院学报, 2011, 36(10): 1071-1074.
[4]	周希法 , 王建华 , 许锡元 . 食管放射性损伤的病理学基础及其与照射剂量的相关性. 蚌埠医学院学报, 2005, 30(5): 476-477.
[5]	王立群 , 赵卫东 , 席玉玲 , 焦雪娟 , 承泽农 . p53和survivin在交界性上皮性卵巢肿瘤中的表达及其临床意义. 蚌埠医学院学报, 2011, 36(10): 1078-1080,1083.
[6]	朱小晖 , 张申华 . 卵巢癌中Metadherin蛋白表达的临床病理意义. 蚌埠医学院学报, 2016, 41(5): 583-585. doi: 10.13898/j.cnki.issn.1000-2200.2016.05.008
[7]	郭苏阳 , 赵燕 , 李胜泽 . 缺氧相关蛋白碳酸酐酶-Ⅸ在上皮性卵巢癌中的表达及临床意义. 蚌埠医学院学报, 2014, 38(4): 442-444.
[8]	马方昊 , 靳丽杰 , 叶国柳 , 杜丹丽 . miR-655在上皮性卵巢癌中的表达研究. 蚌埠医学院学报, 2020, 45(2): 181-184. doi: 10.13898/j.cnki.issn.1000-2200.2020.02.012
[9]	衡燕春 , 马珊珊 , 马玲 . 调节性B细胞在卵巢癌病人外周血中表达及其临床意义. 蚌埠医学院学报, 2021, 46(6): 767-770, 774. doi: 10.13898/j.cnki.issn.1000-2200.2021.06.015
[10]	李静 , 桂琳 , 金强 , 殷献录 , 刘桂玲 , 姚伟 . 血管内皮生长因子与血液肿瘤的相关性研究. 蚌埠医学院学报, 2012, 36(3): 364-367.
[11]	朱静 , 宋悦 . 低剂量LBH589通过PI3K/AKT途径诱导对上皮性卵巢癌细胞凋亡作用机制研究. 蚌埠医学院学报, 2019, 44(6): 708-711. doi: 10.13898/j.cnki.issn.1000-2200.2019.06.003
[12]	李玉梅 , 汪蕊 , 欧玉荣 , 吴穷 , 侯鑫 , 钱秀娟 , 汪子书 , 杨燕 , 谈燚 . PTEN和p53在肝细胞癌中的表达及其相关性. 蚌埠医学院学报, 2013, 37(12): 1551-1554.
[13]	马志刚 , 钱中清 . 结核分枝杆菌H37Ra株fbpC基因的克隆与表达. 蚌埠医学院学报, 2014, 38(2): 145-147.
[14]	杨晓东 . 卵巢癌组织中miR-377的表达及其与临床病理参数的关系. 蚌埠医学院学报, 2021, 46(2): 210-213. doi: 10.13898/j.cnki.issn.1000-2200.2021.02.019
[15]	彭程 , 李敏 , 周颖 , 赵卫东 , 冯定庆 , 凌斌 . 白细胞介素-6在上皮性卵巢癌中的表达及其意义. 蚌埠医学院学报, 2009, 34(2): 117-119.
[16]	刘德纯 , 李宏军 . 艾滋病合并恶性肿瘤10例临床病理分析. 蚌埠医学院学报, 2015, 40(11): 1488-1491. doi: 10.13898/j.cnki.issn.1000-2200.2015.11.009
[17]	张春蕾 , 陈艳梅 , 赵洪焕 , 徐进霞 , 韩素桂 , 李涛 , 孙星 , 龚振英 . CA724、HE4检测对妊娠合并卵巢癌病人诊断价值及其与超声造影参数相关性. 蚌埠医学院学报, 2022, 47(3): 368-372. doi: 10.13898/j.cnki.issn.1000-2200.2022.03.024
[18]	胡怀远 , 雍翔 , 宋瑞 , 张辉 , 武雪芹 , 刘岩 . 原发性卵巢甲状腺肿类癌4例临床病理分析. 蚌埠医学院学报, 2014, 39(9): 1173-1176.
[19]	俞岚 , 甘怀勇 , 汪万英 . VEGF-C和VEGFR-3在卵巢癌的表达及其临床意义. 蚌埠医学院学报, 2007, 32(4): 396-398,506.
[20]	赵晓婷 , 马玲 . 预测卵巢癌复发的相关因素研究进展. 蚌埠医学院学报, 2017, 42(9): 1290-1293. doi: 10.13898/j.cnki.issn.1000-2200.2017.09.044

点击查看大图

计量

文章访问数: 2273
HTML全文浏览量: 203
PDF下载量: 17
被引次数: 0

凋亡抑制基因Livin在卵巢上皮性癌组织中的表达及其与PTEN的相关性研究

作者简介: 王玲玲(1977-),女,主治医师,讲师.

1. 安徽医科大学附属省立医院妇产科, 安徽合肥 230032;
2. 蚌埠医学院第一附属医院妇产科, 安徽蚌埠 233004;
3. 蚌埠医学院病理学教研室, 安徽蚌埠 233030

收稿日期: 2010-12-03

关键词:

摘要: 目的: 探讨Livin和张力蛋白同源10q丢失的磷酸酶基因(phosphatase and tensin hornology deleted on chromosome 10,PTEN)的表达与卵巢上皮性癌的临床病理学特征的关系及其相关性。方法: 采用免疫组织化学EliVision法检测60例卵巢上皮性癌组织、20例良性卵巢上皮性肿瘤及20例正常卵巢组织中Livin及PTEN表达情况。结果: 卵巢上皮性癌中Livin阳性率(80.0%)均明显高于卵巢良性上皮性肿瘤(10.0%)及正常卵巢组织(5.0%)(P<0.01)。卵巢上皮性癌的组织病理学分级间Livin的阳性率差异有统计学意义(P<0.01),而在临床分期及淋巴结转移中差异均无统计学意义(P>0.05)。卵巢上皮性癌中PTEN的阳性率(26.7%)均明显低于卵巢良性上皮性肿瘤(95.0%)及正常卵巢组织(100.0%)(P<0.01);卵巢上皮性癌的临床分期、组织病理学分级及淋巴结有无转移间PTEN的阳性率差异均有统计学意义(P<0.01)。卵巢上皮性癌中Livin的阳性率与PTEN的阳性率呈负相关关系(P<0.01)。结论: Livin的表达上调及PTEN的表达下调在卵巢上皮性癌的发生、分化进展中起重要作用,Livin基因有可能成为治疗卵巢癌的新靶点。

English Abstract

Relationship of expression of apoptosis inhibitor gene Livin and cancer surppresser gene PTEN in epithelial ovarian carcinoma

1. Department of Obstetrics and Gynecology, Anhui Provinical Hospital, Anhui Medical University, Hefei Anhui 230032;
2. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;
3. Department of Pathology, Bengbu Medical College, Bengbu Anhui 233030, China

Received Date: 2010-12-03

Abstract: Objective: To study the expression and pathological characteristics of Livin and PTEN proteins in epithelial ovarian carcinoma as well as their inter-relationship. Methods: The Expression of Livin and PTEN in 60 samples of ovarian epithelial carcinoma,20 samples of benign ovarian epithelial tumor and 20 normal ovarian tissues were detected by immunohistochemistry. Results: The Livin protein expression (80.0%) in epithelial ovarian carcinoma tissues was significantly higher than that of benign ovarian epithelial tumors (10.0%) and normal ovarian tissues (5.0%) (P<0.01). The expression of Livin had a positive correlation with the tumor grade,but no statistical correlation with the tumor stage or lymph node metastasis. The positive expression of PTEN protein in epithelial ovarian carcinoma (26.7%) was significantly lower than that in benign ovarian epithelial tumors (95.0%) and normal ovarian tissues (100.0) (P<0.01). The expression of PTEN was negatively related to the tumor stage,tumor grade and lymph node metastasis (P<0.01); the expression of Livin was negatively correlated with the expression of PTEN (P<0.01). Conclusions: Up-regulated expression of Livin and down-regulated expression of PTEN may play an important role in the process of carcinogenesis and differentiation of epithelial ovarian carcinoma. Livin may be useful targets for treatment of ovarian carcinoma.