不同感染部位分离的金黄色葡萄球菌一般特征和耐药性分析

赵燕; 马筱玲; 蔡朝阳

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不同感染部位分离的金黄色葡萄球菌一般特征和耐药性分析

赵燕 , 马筱玲 , 蔡朝阳

文章导航 > 蚌埠医学院学报 > 2008, 33 > 4: (474-477)

引用本文:

Citation:

不同感染部位分离的金黄色葡萄球菌一般特征和耐药性分析

1. 安徽医科大学第一附属医院检验科, 安徽合肥 230022;
2. 安徽省立医院检验科, 安徽合肥 230001;
3. 安徽省合肥市第二人民医院检验科, 230011

作者简介: 赵燕(1975-),女,硕士,主管技师.

中图分类号: R515;R378.11

General characteristics and antibiotics resistance of Staphylococcus aureus isolated from various locus of infection

1. Department of Laboratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei Anhui 230022;
2. Department of Laboratory Medicine, Anhui Provincial Hospital, Hefei Anhui 230001;
3. Department of Laboratory Medicine, The Second Hospital of Hefei, Hefei Anhui 230011, China
CLC number: R515;R378.11

摘要: 目的:了解不同感染部位分离的金黄色葡萄球菌(Staphylococcus aureus,SA)一般特征及耐药性,指导临床合理用药。方法:从不同感染部位的病原菌均采用Vitek-32微生物分析系统进行鉴定和药物敏感性检测。结果:分离出SA共116株,其中住院患者的年龄显著大于门诊患者(P<0.05);住院患者呼吸道感染分离的SA对14种抗菌药物的药敏结果显示,耐药率>60%的抗菌药物分别为青霉素G、氨苄西林、红霉素、头孢唑啉、苯唑西林、左氧氟沙星、庆大霉素、四环素、复方磺胺甲口恶唑、氯洁霉素;住院患者呼吸道感染分离的SA对多种抗菌药物的耐药率、耐甲氧西林SA (MRSA)及多重耐药菌株的分离率均显著高于其它感染部位分离株(P<0.05);门诊患者皮肤软组织感染分离的SA对多种抗菌药物的耐药率、MRSA及多重耐药菌株的分离率均显著低于住院患者不同感染部位分离株(P<0.05)。结论:门诊患者皮肤软组织感染和住院患者呼吸道感染分离的SA不同于住院患者其它感染部位分离株,临床用药应区别对待;住院患者呼吸道感染分离株对多种抗菌药物的耐药率、MRSA及多重耐药菌株的分离率较高,临床应加强耐药性监测,并防治多重耐药菌株的传播流行。
- 细菌感染 /
- 金黄色葡萄球菌 /
- 微生物敏感试验
Abstract: Objective: To study the general characteristics and antibiotic resistance of Staphylococcus aureus isolated from various locus of infection and to guide antibiotic chemotherapy in clinics.Methods: The pathogenic bacteria isolated from various locus of infection were identified with Vitek-32 automatic microbial monitor and performed antimicrobial sensitivity test.Results: One hundred sixteen strains of Staphylococcus aureus were isolated,and the age of inpatients was much higher than that of outpatients(P<0.05).The Staphylococcus aureus isolated from the respiratory infection of the inpatients were tested with 14 antibacterials,and the antimicrobial agents with a resistant rate over 60% were penicillin G,ampicillin,erythromycin,cefazolin,levofloxacin,gentamycin,tetraycline,terimethoprim-sulfamethoxzole and clindamycin.The Staphylococcus aureus isolated from respiratory infection of inpatient had a higher resistant rate,detection rate and multidrug resistance than the strains isolated from other locus of infecion(P<0.05).The Staphylococcus aureus isolated from skin and soft tissue infection of outpatient had a higher resistance to multidrug antimicrobial agents,higher detection rate of MRSA than the strains islated from other locus of infecion of inpatients(P<0.05).Conclusions: Staphlococcus aureus isolated from the respiratory infection of inpatient and the skin and soft tissue infection of outpatients were different from strains isolated from other locus of infection of inpatients,and use of antibiotics should be different.Staphylococcus aureus isolated from the respiratory infection of inpatients were highly resistant to most of the antimicrobial agents and demonstrated a higher detection rate of MRSA.Monitoring of drug resistance should be strengthened to prevent the spread and epidemic of the resistant strains.
- bacterial infections /
- Staphylococcus aureus /
- microbial sensitivity tests

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不同感染部位分离的金黄色葡萄球菌一般特征和耐药性分析

作者简介: 赵燕(1975-),女,硕士,主管技师.

1. 安徽医科大学第一附属医院检验科, 安徽合肥 230022;
2. 安徽省立医院检验科, 安徽合肥 230001;
3. 安徽省合肥市第二人民医院检验科, 230011

收稿日期: 2007-08-07

关键词:

摘要: 目的:了解不同感染部位分离的金黄色葡萄球菌(Staphylococcus aureus,SA)一般特征及耐药性,指导临床合理用药。方法:从不同感染部位的病原菌均采用Vitek-32微生物分析系统进行鉴定和药物敏感性检测。结果:分离出SA共116株,其中住院患者的年龄显著大于门诊患者(P<0.05);住院患者呼吸道感染分离的SA对14种抗菌药物的药敏结果显示,耐药率>60%的抗菌药物分别为青霉素G、氨苄西林、红霉素、头孢唑啉、苯唑西林、左氧氟沙星、庆大霉素、四环素、复方磺胺甲口恶唑、氯洁霉素;住院患者呼吸道感染分离的SA对多种抗菌药物的耐药率、耐甲氧西林SA (MRSA)及多重耐药菌株的分离率均显著高于其它感染部位分离株(P<0.05);门诊患者皮肤软组织感染分离的SA对多种抗菌药物的耐药率、MRSA及多重耐药菌株的分离率均显著低于住院患者不同感染部位分离株(P<0.05)。结论:门诊患者皮肤软组织感染和住院患者呼吸道感染分离的SA不同于住院患者其它感染部位分离株,临床用药应区别对待;住院患者呼吸道感染分离株对多种抗菌药物的耐药率、MRSA及多重耐药菌株的分离率较高,临床应加强耐药性监测,并防治多重耐药菌株的传播流行。

English Abstract

General characteristics and antibiotics resistance of Staphylococcus aureus isolated from various locus of infection

1. Department of Laboratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei Anhui 230022;
2. Department of Laboratory Medicine, Anhui Provincial Hospital, Hefei Anhui 230001;
3. Department of Laboratory Medicine, The Second Hospital of Hefei, Hefei Anhui 230011, China

Received Date: 2007-08-07

Abstract: Objective: To study the general characteristics and antibiotic resistance of Staphylococcus aureus isolated from various locus of infection and to guide antibiotic chemotherapy in clinics.Methods: The pathogenic bacteria isolated from various locus of infection were identified with Vitek-32 automatic microbial monitor and performed antimicrobial sensitivity test.Results: One hundred sixteen strains of Staphylococcus aureus were isolated,and the age of inpatients was much higher than that of outpatients(P<0.05).The Staphylococcus aureus isolated from the respiratory infection of the inpatients were tested with 14 antibacterials,and the antimicrobial agents with a resistant rate over 60% were penicillin G,ampicillin,erythromycin,cefazolin,levofloxacin,gentamycin,tetraycline,terimethoprim-sulfamethoxzole and clindamycin.The Staphylococcus aureus isolated from respiratory infection of inpatient had a higher resistant rate,detection rate and multidrug resistance than the strains isolated from other locus of infecion(P<0.05).The Staphylococcus aureus isolated from skin and soft tissue infection of outpatient had a higher resistance to multidrug antimicrobial agents,higher detection rate of MRSA than the strains islated from other locus of infecion of inpatients(P<0.05).Conclusions: Staphlococcus aureus isolated from the respiratory infection of inpatient and the skin and soft tissue infection of outpatients were different from strains isolated from other locus of infection of inpatients,and use of antibiotics should be different.Staphylococcus aureus isolated from the respiratory infection of inpatients were highly resistant to most of the antimicrobial agents and demonstrated a higher detection rate of MRSA.Monitoring of drug resistance should be strengthened to prevent the spread and epidemic of the resistant strains.