女性2型糖尿病患者骨密度及临床相关因素分析

时照明; 章秋; 王长江; 王佑民; 张晓梅

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

女性2型糖尿病患者骨密度及临床相关因素分析

时照明 , 章秋 , 王长江 , 王佑民 , 张晓梅

文章导航 > 蚌埠医学院学报 > 2009, 34 > 7: (603-605)

引用本文:

Citation:

女性2型糖尿病患者骨密度及临床相关因素分析

1. 蚌埠医学院第一附属医院内分泌科, 安徽蚌埠 233004;
2. 安徽医科大学第一附属医院内分泌科, 安徽合肥 230022

作者简介: 时照明(1973-),男,硕士,讲师,副主任医师.

中图分类号: R587.1

Analysis of bone mineral density and clinical related factors in female patients with type 2 diabetes mellitus

1. Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;
2. Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei Anhui 230022, China
CLC number: R587.1

摘要: 目的:探讨女性2型糖尿病(type 2 diabetes mellitus,T2DM)患者的骨密度(BMD)变化及临床相关因素对BMD的影响。方法:采用双能X线骨密度仪测定127例女性T2DM患者和78例非糖尿病对照者正位腰椎(L₂~L₄)及股骨近端(Neck、Ward's区、G.T.)的BMD,按年龄和病程分组进行比较,并对糖尿病患者的BMD与年龄、绝经年限、体重指数(BMI)、病程、糖化血红蛋白A₁c(HbA₁c)、血脂等指标进行多元逐步回归分析。结果:50~59岁组女性T2DM患者各部位BMD均高于对照组(P<0.05~P<0.01);60~69岁和70~79岁组L₂、股骨近端BMD,以及70~79岁组L₃BMD均高于对照组(P<0.05~P<0.01);各年龄组Ward's区BMD测定值明显低于腰椎、Neck和G.T.(P<0.01)。T2DM病程≤ 5年、6~10年和>10年组各部位BMD差异均无统计学意义(P>0.05)。T2DM患者年龄与腰椎BMD均呈负相关(P<0.05~P<0.01),绝经年限与Neck、Ward's区、G.T.BMD呈负相关(P<0.01),BMI与Neck、Ward's区、G.T.BMD呈正相关(P<0.01),病程、HbA₁c、血脂与BMD无显著相关。结论:女性T2DM患者绝经后各部位BMD明显高于或不低于非糖尿病对照者;年龄大、绝经年限长是T2DM患者BMD降低的危险因素;BMI是T2DM患者BMD的保护性因素。
- 糖尿病,2型 /
- 骨密度 /
- 骨质疏松症
Abstract: Objective: To investigate the changes of bone mineral density(BMD) in female patients with type 2 diabetes mellitus(T2DM) and the possible clinical related factors involved.Methods: The BMD was measured with the dual-energy X-ray absorptiometry technique at the lumbar(L₂-L₄) and proximal femur of 127 female patients with T2DM and 78 non-diabetic controls.The patients and controls were divided into groups according to the age and diabetic duration.The correlation of BMD with the age,duration of menopause,body mass index(BMI),course,HbA1c and serum lipids was studied by multivariate stepwise regression analysis.Results: The T2DM patients in 55-59 years-old group had a higher BMD than the controls(P<0.05 or P<0.01);the patients in 60-69 and 70-79 year-old groups had a higher BMD at L₂ than the controls(P<0.05 or P<0.01);and the patients in 70-79 year-old group had a higher BMD at L₃ than the controls(P<0.05 or P<0.01).The BMD at Ward's triangle was lower than that at lumbar,neck and G.T in each group(P<0.01).The BMD had no significant difference in T2DM patients with a diabetic course of less than 5 years,between 6-10 years and more than 10 years(P>0.05).Stepwise regression analysis showed that BMD at lumbar was negatively correlated with the age(P<0.05 or P<0.01);BMD at neck,Ward's triangle and G.T.was negatively correlated with the duration of menopause(P<0.01),and positively correlated with BMI(P<0.01).Diabetic duration,HbA1c and serum lipids had no correlation with BMD in T2DM patients.Conclusions: BMD in postmenopausal T2DM patients is significantly higher than or similar to that in the controls.Aging and long duration of menopause are risk factors for decreased BMD in T2DM patients.BMI may be a protective factor for bone loss.
- diabetes mellitus,type 2 /
- bone mineral density /
- osteoporosis

[1]	张峰 . 2型糖尿病患者血脂水平与骨密度的相关性. 蚌埠医学院学报, 2013, 37(2): 170-172;169.
[2]	曾玲 . 人文关怀护理联合功能锻炼对骨质疏松症患者焦虑情绪及骨密度的影响. 蚌埠医学院学报, 2016, 41(6): 830-832. doi: 10.13898/j.cnki.issn.1000-2200.2016.06.041
[3]	赵萍 , 王涛 , 侯传云 , 孙超 . 绝经后女性血脂水平与骨密度的相关性研究. 蚌埠医学院学报, 2022, 47(9): 1206-1209. doi: 10.13898/j.cnki.issn.1000-2200.2022.09.013
[4]	李春梅 , 陈频 , 林忆阳 , 徐向进 . 维格列汀对2型糖尿病围绝经期妇女骨代谢及骨密度水平的影响. 蚌埠医学院学报, 2019, 44(11): 1484-1486. doi: 10.13898/j.cnki.issn.1000-2200.2019.11.013
[5]	李娟 , 徐家新 , 王春 , 吕高友 , 金国玺 . 2型糖尿病慢性并发症中血脂的变化及其意义. 蚌埠医学院学报, 2015, 40(12): 1649-1650. doi: 10.13898/j.cnki.issn.1000-2200.2015.12.011
[6]	胡英 . 共情技术对老年性骨质疏松症患者生活质量、心理状态及主观幸福感的影响. 蚌埠医学院学报, 2015, 40(9): 1281-1283,1286. doi: 10.13898/j.cnki.issn.1000-2200.2015.09.049
[7]	吴楠 , 朱坤 , 叶雨辰 , 张知理 , 程宇 , 刘静宇 , 许杨康 , 张飞飞 , 宛森林 , 张长春 . 骨质疏松和Modic改变的相关性分析. 蚌埠医学院学报, 2021, 46(3): 307-310. doi: 10.13898/j.cnki.issn.1000-2200.2021.03.007
[8]	袁玉山 , 马培旗 , 彭彬 , 张宗夕 , 胡小明 , 张小艳 , 王仲秋 , 王家亮 . 基于定量CT分析血糖、血脂、腹部脂肪与骨密度的关系. 蚌埠医学院学报, 2022, 47(5): 648-651. doi: 10.13898/j.cnki.issn.1000-2200.2022.05.023
[9]	王昕 , 薄明琪 , 纪捷 , 王传彬 , 董江宁 , 王震寰 . 双能CT虚拟平扫定量评估骨质疏松的可行性研究. 蚌埠医学院学报, 2022, 47(6): 793-797. doi: 10.13898/j.cnki.issn.1000-2200.2022.06.023
[10]	曹澍 , 邵松 . 不同手术方式治疗老年髋部骨质疏松性骨折术后对侧髋部再骨折的风险及对策. 蚌埠医学院学报, 2021, 46(6): 775-779. doi: 10.13898/j.cnki.issn.1000-2200.2021.06.017
[11]	雷丙俊 . 经皮单侧穿刺椎体后凸成形术和椎体成形术治疗老年椎体骨质疏松性骨折疗效比较. 蚌埠医学院学报, 2017, 42(7): 926-929. doi: 10.13898/j.cnki.issn.1000-2200.2017.07.028
[12]	李彦飞 , 霍喜卫 , 李东风 , 胡成栋 , 王飞 , 李海涛 . 术前测量联合术中精准穿刺经皮椎体后凸成形术治疗骨质疏松性椎体压缩骨折的疗效分析. 蚌埠医学院学报, 2021, 46(10): 1384-1388, 1392. doi: 10.13898/j.cnki.issn.1000-2200.2021.10.015
[13]	邱艳 , 赵凌杰 , 商玮 , 赵智明 , 蔡辉 . 佐剂性关节炎大鼠骨密度及血清骨保护素和核因子-κB受体激活因子配体的变化. 蚌埠医学院学报, 2014, 39(9): 1153-1155.
[14]	王旸 , 曹玉茹 , 陈琳洁 , 李季青 , 江超 . 女性类风湿关节炎患者骨密度变化的影响因素. 蚌埠医学院学报, 2012, 36(11): 1289-1293.
[15]	梅永君 , 王旸 , 曹玉茹 , 李志军 , 陈琳洁 , 石士奎 , 潘海峰 . 强直性脊柱炎患者骨密度的影响因素分析. 蚌埠医学院学报, 2016, 41(10): 1272-1274. doi: 10.13898/j.cnki.issn.1000-2200.2016.10.004
[16]	刘红 , 马俊岭 , 侯钦午 , 郭海英 , 刘定娟 , 郭薇琼 , 陈佳维 . 上海市北蔡社区青年男性骨密度水平调查. 蚌埠医学院学报, 2017, 42(12): 1668-1669,1673. doi: 10.13898/j.cnki.issn.1000-2200.2017.12.031
[17]	代瑞 , 杨枋 . 不同剂量促甲状腺激素对分化型甲状腺癌病人术后相关指标的影响. 蚌埠医学院学报, 2018, 43(4): 510-512. doi: 10.13898/j.cnki.issn.1000-2200.2018.04.025
[18]	赵萍 , 李志军 , 谢长好 , 陈琳洁 , 曹玉茹 , 王旸 . 女性骨关节炎骨质疏松危险因素分析. 蚌埠医学院学报, 2016, 41(5): 580-583. doi: 10.13898/j.cnki.issn.1000-2200.2016.05.007
[19]	黄滢芝 , 汤步阳 , 常琳 , 郭法平 . 平均血小板体积变化与2型糖尿病和糖尿病肾病的关系. 蚌埠医学院学报, 2014, 38(1): 58-60.
[20]	张梅 , 陈冬 . 胰岛素强化治疗初诊2型糖尿病的疗效观察. 蚌埠医学院学报, 2008, 33(1): 54-55.

点击查看大图

计量

文章访问数: 2240
HTML全文浏览量: 177
PDF下载量: 5
被引次数: 0

女性2型糖尿病患者骨密度及临床相关因素分析

作者简介: 时照明(1973-),男,硕士,讲师,副主任医师.

1. 蚌埠医学院第一附属医院内分泌科, 安徽蚌埠 233004;
2. 安徽医科大学第一附属医院内分泌科, 安徽合肥 230022

收稿日期: 2008-12-06

关键词:

摘要: 目的:探讨女性2型糖尿病(type 2 diabetes mellitus,T2DM)患者的骨密度(BMD)变化及临床相关因素对BMD的影响。方法:采用双能X线骨密度仪测定127例女性T2DM患者和78例非糖尿病对照者正位腰椎(L₂~L₄)及股骨近端(Neck、Ward's区、G.T.)的BMD,按年龄和病程分组进行比较,并对糖尿病患者的BMD与年龄、绝经年限、体重指数(BMI)、病程、糖化血红蛋白A₁c(HbA₁c)、血脂等指标进行多元逐步回归分析。结果:50~59岁组女性T2DM患者各部位BMD均高于对照组(P<0.05~P<0.01);60~69岁和70~79岁组L₂、股骨近端BMD,以及70~79岁组L₃BMD均高于对照组(P<0.05~P<0.01);各年龄组Ward's区BMD测定值明显低于腰椎、Neck和G.T.(P<0.01)。T2DM病程≤ 5年、6~10年和>10年组各部位BMD差异均无统计学意义(P>0.05)。T2DM患者年龄与腰椎BMD均呈负相关(P<0.05~P<0.01),绝经年限与Neck、Ward's区、G.T.BMD呈负相关(P<0.01),BMI与Neck、Ward's区、G.T.BMD呈正相关(P<0.01),病程、HbA₁c、血脂与BMD无显著相关。结论:女性T2DM患者绝经后各部位BMD明显高于或不低于非糖尿病对照者;年龄大、绝经年限长是T2DM患者BMD降低的危险因素;BMI是T2DM患者BMD的保护性因素。

English Abstract

Analysis of bone mineral density and clinical related factors in female patients with type 2 diabetes mellitus

1. Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;
2. Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei Anhui 230022, China

Received Date: 2008-12-06

Abstract: Objective: To investigate the changes of bone mineral density(BMD) in female patients with type 2 diabetes mellitus(T2DM) and the possible clinical related factors involved.Methods: The BMD was measured with the dual-energy X-ray absorptiometry technique at the lumbar(L₂-L₄) and proximal femur of 127 female patients with T2DM and 78 non-diabetic controls.The patients and controls were divided into groups according to the age and diabetic duration.The correlation of BMD with the age,duration of menopause,body mass index(BMI),course,HbA1c and serum lipids was studied by multivariate stepwise regression analysis.Results: The T2DM patients in 55-59 years-old group had a higher BMD than the controls(P<0.05 or P<0.01);the patients in 60-69 and 70-79 year-old groups had a higher BMD at L₂ than the controls(P<0.05 or P<0.01);and the patients in 70-79 year-old group had a higher BMD at L₃ than the controls(P<0.05 or P<0.01).The BMD at Ward's triangle was lower than that at lumbar,neck and G.T in each group(P<0.01).The BMD had no significant difference in T2DM patients with a diabetic course of less than 5 years,between 6-10 years and more than 10 years(P>0.05).Stepwise regression analysis showed that BMD at lumbar was negatively correlated with the age(P<0.05 or P<0.01);BMD at neck,Ward's triangle and G.T.was negatively correlated with the duration of menopause(P<0.01),and positively correlated with BMI(P<0.01).Diabetic duration,HbA1c and serum lipids had no correlation with BMD in T2DM patients.Conclusions: BMD in postmenopausal T2DM patients is significantly higher than or similar to that in the controls.Aging and long duration of menopause are risk factors for decreased BMD in T2DM patients.BMI may be a protective factor for bone loss.