丹参多酚酸盐治疗老年冠心病合并心力衰竭的临床观察

王邦俊; 王志芳; 周利民

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丹参多酚酸盐治疗老年冠心病合并心力衰竭的临床观察

王邦俊 , 王志芳 , 周利民

文章导航 > 蚌埠医学院学报 > 2014, 39 > 12: (1644-1646)

引用本文:

Citation:

丹参多酚酸盐治疗老年冠心病合并心力衰竭的临床观察

1. 滁州学院校医院内科, 安徽滁州 239012;
2. 安徽省滁州市第一人民医院心内科, 239000

作者简介: 王邦俊(1963-), 男, 主任医师.

中图分类号: R541.61

Effect of salvianolate in the treatment of the elderly patients with coronary artery disease complicated with heart failure

1. Department of Internal Medicine, The Hospital of Chuzhou College, Chuzhou Anhui 239012;
2. Department of Cardiology, The First People's Hospital of Chuzhou, Chuzhou Anhui 239000, China
CLC number: R541.61

摘要: 目的: 观察丹参多酚酸盐治疗老年冠心病合并心力衰竭(心衰)的临床疗效.方法: 老年冠心病合并心衰患者72例,按照随机数字表法分为对照组和治疗组各36例,对照组常规治疗,治疗组在常规治疗基础上加用丹参多酚酸盐静脉滴注,治疗14 d.治疗前后分别观察2组患者射血分数(EF)、每搏量(SV)、血浆N末端B型利钠肽原(NT-proBNP)水平以及Lee心衰积分,并依据Lee心衰积分评价2组临床疗效.结果: 2组患者经治疗后EF、SV均较治疗前有明显升高(P< 0.01),且治疗组均较对照组提升明显(P< 0.01);2组患者Nt-proBNP和Lee心衰积分均较治疗前显著下降(P< 0.01),且治疗组均优于对照组(P< 0.05).对照组有效率47.22%,治疗组有效率75.00%,2组疗效差异有统计学意义(P< 0.01).结论: 在常规治疗基础上加用丹参多酚酸盐能够改善老年冠心病合并心力衰竭患者的心功能,具有较好的临床疗效,值得推广.
- 心力衰竭 /
- 丹参多酚酸盐 /
- 临床观察
Abstract: Objective: To observe the clinical effects of salvianolate in the treatment of the elderly patients with coronary artery disease complicated with heart failure.Methods: Seventy-two elderly patients with coronary artery disease complicated with heart failure were randomly divided into the control group and salvianolate group using number table method(36 cases each group).The control group were treated with conventional method,the salvianolate group were treated with salvianolate by intravenous injection based on conventional method for 14 days.The ejection fraction(EF),stroke volume(SV),N-terminal type B natriuretic peptide(Nt-proBNP) level and HF Lee score in two groups were measured before and after treatment,the clinical effects between two groups were evaluated according to the HF Lee score.Results: Compared before treatment,the EF and SV in two groups increased significantly after treatment(P< 0.01),and the increasing degrees of EF and SV in salvianolate group were significantly higher than those in control group(P< 0.01).Compared before treatment,the Nt-proBNP level and HF Lee score in two groups decreased significantly after treatment(P< 0.01),and the Nt-proBNP level and HF Lee score in salvianolate group were significantly better than those in control group(P< 0.05).The effective rates in control group and salvianolate group were 47.22% and 75.00%,respectively,the difference of which was statistically significant(P< 0.01).Conclusions: The treatment of coronary artery disease complicated with heart failure in the elderly patients with salvianolate based on the conventional therapy can significantly improve the cardiac function of patients,which has good clinical effects,and is worth promoting.
- heart failure /
- salvianolate /
- clinical observation

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丹参多酚酸盐治疗老年冠心病合并心力衰竭的临床观察

作者简介: 王邦俊(1963-), 男, 主任医师.

1. 滁州学院校医院内科, 安徽滁州 239012;
2. 安徽省滁州市第一人民医院心内科, 239000

收稿日期: 2014-06-24

关键词:

摘要: 目的: 观察丹参多酚酸盐治疗老年冠心病合并心力衰竭(心衰)的临床疗效.方法: 老年冠心病合并心衰患者72例,按照随机数字表法分为对照组和治疗组各36例,对照组常规治疗,治疗组在常规治疗基础上加用丹参多酚酸盐静脉滴注,治疗14 d.治疗前后分别观察2组患者射血分数(EF)、每搏量(SV)、血浆N末端B型利钠肽原(NT-proBNP)水平以及Lee心衰积分,并依据Lee心衰积分评价2组临床疗效.结果: 2组患者经治疗后EF、SV均较治疗前有明显升高(P< 0.01),且治疗组均较对照组提升明显(P< 0.01);2组患者Nt-proBNP和Lee心衰积分均较治疗前显著下降(P< 0.01),且治疗组均优于对照组(P< 0.05).对照组有效率47.22%,治疗组有效率75.00%,2组疗效差异有统计学意义(P< 0.01).结论: 在常规治疗基础上加用丹参多酚酸盐能够改善老年冠心病合并心力衰竭患者的心功能,具有较好的临床疗效,值得推广.

English Abstract

Effect of salvianolate in the treatment of the elderly patients with coronary artery disease complicated with heart failure

1. Department of Internal Medicine, The Hospital of Chuzhou College, Chuzhou Anhui 239012;
2. Department of Cardiology, The First People's Hospital of Chuzhou, Chuzhou Anhui 239000, China

Received Date: 2014-06-24

Abstract: Objective: To observe the clinical effects of salvianolate in the treatment of the elderly patients with coronary artery disease complicated with heart failure.Methods: Seventy-two elderly patients with coronary artery disease complicated with heart failure were randomly divided into the control group and salvianolate group using number table method(36 cases each group).The control group were treated with conventional method,the salvianolate group were treated with salvianolate by intravenous injection based on conventional method for 14 days.The ejection fraction(EF),stroke volume(SV),N-terminal type B natriuretic peptide(Nt-proBNP) level and HF Lee score in two groups were measured before and after treatment,the clinical effects between two groups were evaluated according to the HF Lee score.Results: Compared before treatment,the EF and SV in two groups increased significantly after treatment(P< 0.01),and the increasing degrees of EF and SV in salvianolate group were significantly higher than those in control group(P< 0.01).Compared before treatment,the Nt-proBNP level and HF Lee score in two groups decreased significantly after treatment(P< 0.01),and the Nt-proBNP level and HF Lee score in salvianolate group were significantly better than those in control group(P< 0.05).The effective rates in control group and salvianolate group were 47.22% and 75.00%,respectively,the difference of which was statistically significant(P< 0.01).Conclusions: The treatment of coronary artery disease complicated with heart failure in the elderly patients with salvianolate based on the conventional therapy can significantly improve the cardiac function of patients,which has good clinical effects,and is worth promoting.