Abstract: Objective: To observe the clinical efficacy of inhalation treatment with salbutamol and budesonide combination for acute attack of bronchial asthma. Methods: Sixty-three cases of acute attack of bronchial asthma were randomly divided into two groups,30 patients in control group with salbutamol inhalation,33 patients in treatment group treated with salbutamol combined with budesonide. The overall efficacy,main symptoms,sign duration time and the changes of lung function in the two groups were compared. Results: The total effective rate was 86.67% and 93.94% in control group and treatment group,respectively,there was no statistical difference in the two groups(P > 0.05). In treatment group, chest tightness, shortness of breath, coughing, wheezing and other lung symptoms, sign disappeared time were significantly shortened compared with control group. The first second forced expiratory volume, forced vital capacity,peak expiratory flow after treatment were significantly higher than before treatment in the two groups(P < 0.01),and the lung function in treatment group was improved more significantly than in control group(P < 0.01). Conclusions: The overall efficacy of budesonide combined with salbutamol inhalation in treatment of asthma is notable,it can remarkably improve symptoms and enhance lung function,which is worthy of clinical application.