炎症性肠病与TLR/MyD88信号通路研究进展
-
摘要: 炎症性肠病(inflammatory bowel disease,IBD)是一种非特异性的慢性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(crohn disease,CD)。临床主要表现为反复腹痛、腹泻、黏液血便。
-
[2] Baumgart DC,Carding SR.Inflammatory bowel disease:cause and immunobiology[J].Lancet,2007,369(9573):1627-1640. [2] Clara A,Judy HC.Inflammatory bowel disease[J].N Engl J Med,2009,361(21):2066-2078. [3] Xavier RJ,Podolsky DK.Unravelling the pathogenesis of inflammatory bowel disease[J].Nature,2007,448(7152):427-434. [4] Maeda S,Hsu LC,Liu H, et al.Nod-mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing[J].Science,2005,307(5710):734-738. [5] Molodecky NA,Kaplan GG.Environmental risk factors for inflammatory bowel disease[J]. Gastroenterol Hepatol(NY)2010,6(5):339-346. [6] Levin A,Shibolet O. Toll-like receptors in inflammatory bowel disease-stepping into uncharted territory[J].World JGastroenterol,2008,14(33):5149-5153. [7] Vollmer J,Krieg AM.Immunotherapeutic applications of CpG oligode-oxynucleotide TLR9 agonists[J].Adv Drug Deliv Rev,2009,61(3):195-204. [8] Berchtold C,Panthel K,Jellbauer S,et al.Superior protective immunity against murine listeriosis by combined vaccination with CpG DNA and recombinant Salmonella enterica serovar typhimurium[J].Infect Immun,2009,77(12):5501-5508. [9] Franklin BS,Parroche P,Atade MA et al.Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function[J].Proc Natl Acad Sci U S A,2009,106(14):5789-5794. [10] [10 Turner JD,Langley RS,Johnston KL,et al.Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis[J]. [11] Nagpal K,Plantinga TS,Wong J, et al.A TIR domain variant of MyD88 adapter-like(Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling[J].J Biol Chem,2009,284(38):25742-25748. [12] Takeuchi O,Takeda K,Hoshino K,et al. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades[J]. Immunol,2000,12 (1):113-117. [13] 陈晓,王启之.Toll 样受体4的信号转导与溃疡性结肠炎的研究进展[J].胃肠病学和肝病学杂志,2010,19(1): 87-89. [14] Dhiman N,Ovsyannikova IG,Vierkant RA,et al.Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine:preliminary results[J].Vaccine,2008. 26(14):1731-1736. [15] Szajnik M,Szczepanski MJ,Czystowska M,et al.TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer[J].Oncogene,2009,28(49): 4353-4363. [16] Zhang X,Shephard F,Kim HB,et al.TILRR,a novel IL-1RI coreceptor,potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB[J]. J Biol Chem,2010,285 (10):7222-7232. [17] Suzuki N,Suzuki S,Duncan GS,et al.Severe impairment of interleukin-1 and toll-like receptor signaling in mice lacking IRAK-4[J]. Nature,2002,416(6882):750-756. [18] Kobayashi K,Hernandez LD,Galan JE,et al.IRAK-M is a negative regulator of toll-like receptor signaling[J].Cell,2002,110( 2): 191-202. [19] Cario E,Gerken G,Podolsky DK.Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function[J]. Gastroenterology,2007,132(4):1359-1374. [20] Vijay-Kumar M,Wu H,Aitken J,et al. Activation of toll-like receptor 3 protects against DSS-induced acute colitis[J].Infamm Bowel Dis,2007,13(7):856-864. [21] Gonzlez-Navajas JM,Fine S,Law J,et al. TLR4 signaling in effector CD4 + T cells regulates TCR activation and experimental colitis in mice[J]. J Clin Invest,2010,120(2):570-581. [22] Fournier B,Williams IR,Gewirtz AT,et al.Toll-like receptor 5 dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection[J].Infect Immun,2009,77(9):4121-4129. [23] Ringwood L,Li L.The involvement of the interleukin-1 receptorassociated kinases in cellular signaling networks controlling inflammation[J].Cytokine,2008,42(1):1-7. [24] Szebeni B,Veres G,Dezsofi A, et al.Increased expression of Tolllike receptor 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease[J].Clin Exp Immunol,2008,151(1):34-41. [25] Stephan RV,Gerhard R. New insights into the pathogenesis of Crohn's disease: are they relevant for therapeutic options[J].SWISS MeD Wkly,2009,139(37/38):527-534. [26] Cai XX,Fei X,Zheng Z, et al.PYK2 interacts with MyD88 and regulates MyD88-mediated NF-B activation in macrophages[J].J Leukocyte Biol,2010,87(3):415-423.
点击查看大图
计量
- 文章访问数: 3422
- HTML全文浏览量: 319
- PDF下载量: 231
- 被引次数: 0