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炎症性肠病与TLR/MyD88信号通路研究进展

路改英 王启之

引用本文:
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炎症性肠病与TLR/MyD88信号通路研究进展

    作者简介: 路改英( 1982 - ),女,硕士研究生。
    通讯作者: 王启之, wangqz2004@sina.com
  • 基金项目:

  • 摘要: 炎症性肠病(inflammatory bowel disease,IBD)是一种非特异性的慢性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(crohn disease,CD)。临床主要表现为反复腹痛、腹泻、黏液血便。
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    [13] 陈晓,王启之.Toll 样受体4的信号转导与溃疡性结肠炎的研究进展[J].胃肠病学和肝病学杂志,2010,19(1): 87-89.
    [14] Dhiman N,Ovsyannikova IG,Vierkant RA,et al.Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine:preliminary results[J].Vaccine,2008. 26(14):1731-1736.
    [15] Szajnik M,Szczepanski MJ,Czystowska M,et al.TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer[J].Oncogene,2009,28(49): 4353-4363.
    [16] Zhang X,Shephard F,Kim HB,et al.TILRR,a novel IL-1RI coreceptor,potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB[J]. J Biol Chem,2010,285 (10):7222-7232.
    [17] Suzuki N,Suzuki S,Duncan GS,et al.Severe impairment of interleukin-1 and toll-like receptor signaling in mice lacking IRAK-4[J]. Nature,2002,416(6882):750-756.
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    [20] Vijay-Kumar M,Wu H,Aitken J,et al. Activation of toll-like receptor 3 protects against DSS-induced acute colitis[J].Infamm Bowel Dis,2007,13(7):856-864.
    [21] Gonzlez-Navajas JM,Fine S,Law J,et al. TLR4 signaling in effector CD4 + T cells regulates TCR activation and experimental colitis in mice[J]. J Clin Invest,2010,120(2):570-581.
    [22] Fournier B,Williams IR,Gewirtz AT,et al.Toll-like receptor 5 dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection[J].Infect Immun,2009,77(9):4121-4129.
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出版历程
  • 收稿日期:  2011-09-07
  • 刊出日期:  2012-01-15

炎症性肠病与TLR/MyD88信号通路研究进展

    通讯作者: 王启之, wangqz2004@sina.com
    作者简介: 路改英( 1982 - ),女,硕士研究生。
  • 1. 蚌埠医学院第一附属医院消化内科, 安徽蚌埠233004
基金项目: 

摘要: 炎症性肠病(inflammatory bowel disease,IBD)是一种非特异性的慢性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(crohn disease,CD)。临床主要表现为反复腹痛、腹泻、黏液血便。

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