硫酸乙酰肝素对肿瘤中碱性成纤维因子的调控作用
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摘要: 侵袭和转移作为肿瘤细胞重要的生物学特性之一,已经成为抗肿瘤研究的一个热点。恶性肿瘤细胞侵袭肿瘤附近的正常组织通过降解细胞外基质(extracellular matrix,ECM)以及组织的血管壁,这个过程最重要的一步就是降解硫酸乙酞肝素蛋白聚糖( heparan sulfate proteoglyc;an HSPG)。
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关键词:
- 肿瘤 /
- 血管生成 /
- 乙酰肝素酶 /
- 碱性成纤维细胞生长因子 /
- 硫酸乙酰肝素蛋白聚糖 /
- 综述
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