麻黄碱对维库溴铵预给药方法插管条件的影响

王宏; 代文涛; 符炜; 张涤非; 金玉坤; 张博; 王南海

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麻黄碱对维库溴铵预给药方法插管条件的影响

王宏 , 代文涛 , 符炜 , 张涤非 , 金玉坤 , 张博 , 王南海

文章导航 > 蚌埠医学院学报 > 2012, 36 > 4: (389-391)

引用本文:

Citation:

麻黄碱对维库溴铵预给药方法插管条件的影响

1.
1. 蚌埠医学院第一附属医院麻醉科;
2.
2. 安徽省太和县人民医院麻醉科，

作者简介: 王宏(1972～)，男，博士，副主任医师

基金项目:

Effects of ephedrine on intubating conditions following priming with vecuronium

1.
1. Department of Anesthesiology，The First Affiliated Hospital of Bengbu Medical College，Bengbu Anhui 233004;
2.
2. Department of Anesthesiology，Taihe People′s Hospital，Taihe Anhui 236600，China

摘要: 目的:探讨预注麻黄碱对维库溴铵预给药方法插管条件的影响。方法:60例患者随机分为对照组和麻黄碱组，每组30例，对照组维库溴铵预给药后注入等量生理盐水;麻黄碱组维库溴铵预给药后注入麻黄碱。麻醉诱导后采用Coopers标准行插管条件评分，并记录插管前和插管后5 min患者平均动脉压和心率。结果:麻黄碱组诱导后下颌松弛度评分和插管反应评分均优于对照组(P0.05和P0.01)，声门位置评分2组差异无统计学意义(P0.05)，麻黄碱组30例患者、对照组23例患者诱导后呈现临床可接受的插管条件，差异有统计学意义(P0.05)。麻黄碱组诱导后较对照组有短时间平均动脉压增高和心率增快(P0.05～P0.01)。结论:预注麻黄碱显著改善维库溴铵预给药方法的插管条件。
- 麻黄碱 /
- 预给药方法 /
- 维库溴铵 /
- 插管条件
Abstract: Objective：To investigate if ephedrine could significantly improve intubating conditions following priming with vecuronium.Methods：Sixty patients were randomly divided into control group and ephedrine group,30 patients in each group.Control group was defined by normal saline following priming with vecuronium and ephedrine group was defined by ephedrine following priming with vecuronium.Intubating condition score was done according to Coopers criteria after anesthesia induction,and mean arterial pressure and heart rate before and after 5 minutes after intubation were recorded.Results：Jaw relaxation score and diaphragmatic response score in ephedrine group were markedly better than control group(P〈0.05 and P〈0.01),but no significant differences of vocal cord position score was found between these two groups(P〉0.05).Intubating conditions were clinically acceptable in all patient in ephedrine group and 23 patients in control group after induction(P〈0.05).Compared with control group,elevated mean arterial pressure and increased heart rate emerged after intubation in ephedrine group(P〈0.05-P〈0.01).Conclusions：Ephedrine can significantly improved intubating conditions following priming with vecuronium.
- ephedrine /
- priming /
- vecuronium /
- intubating condition

[1]	Magorian T,Flannery KB,Miller RD.Comparison of rocuronium,succinylcholine,and vecuronium for rapid-sequence induction ofanesthesia in adult patients[J].Anesthesiology,1993,79(5):913-918.
[2]
[2] Wright PMC,Caldwell JE,Miller RD.Onset and duration ofrocuronium and succinylcholine at the adductor pollicis andlaryngesl adductor muscles in anesthetized humans[J].Anesthesiology,1994,81(5):1110-1115.
[4]
[3] Kirkegaard-Nielsen H,Caldwell J,Berry PD.Rapid trachealintubation with rocuronium:a probability approach to determiningdose[J].Anesthesiology,1999,91(1):131-136.
[6]
[4] Schwarz S,Ilias W,Lackner F,et al.Rapid tracheal intubationwith vecuronium:The priming principle[J].Anesthesiology,1985,62(4):388-391.＜br＞
[5] Saitoh Y,Kaneda K,Murakawa M.Onset of vecuronium-inducedneuromuscular block after a long priming interval[J].J Anesth,2002,16(2):102-107.
[9]
[6] Donati F.Onset of action of relaxants[J].Can J Anaeth,1988,35(3Pt 2):S52-S58.
[11]
[7] Szmuk P,Ezri T,Chelly JE,et al.The onset time of rocuronium isslowed by esmolol and accelerated by ephedrine[J].AnesthAnalg,2000,90(5):1217-1219.
[13]
[8] Gopalakrishna MD,Krishna HM,Shenoy UK.The effect ofephedrine on intubating condiktions and haemodynamics duringrapid tracheal intubation using propofol and rocuronium[J].Br JAnaesth,2007,99(2):191-194.
[15]
[9] Leykin Y,Pellis T,Lucca M,et al.Effects of ephedrine onintubating conditions following priming with rocuronium[J].ActaAnaesthesiol Scand,2005,49(6):792-797.
[17]
[10] Alagha AE,Hajimohamadi F,Rahimi I,et al.Effects of ephedrineon intubating conditions following priming with atracurium:arandomized clinical trial[J].Acta Anaesthesiol Taiwan,2009,47(1):28-31.
[19]
[11] Cooper R,Mirakhur RK,Clarke RSJ,et al.Comparison ofintubating conditions after administration of Org 9426(rocuronium)and suxamethonium[J].Br J Anaesth,1992,69(3):269-273.
[21]
[12] Munoz HR,Gonzalez AG,Dagnino JA,et al.The effect ofephedrine on the onset time of rocuronium[J].Anesth Analg,1997,85(2):437-440.
[23]
[13] Lwasaki H,Igarashi M,Yamauchi M,et al.The effect of cardiacoutput on the onset of neuromuscular block by vecuronium[J].Anaesthesia,1995,50(4):361-362.
[25]
[14] Kim KS,Cheong MA,Jeon JW,et al.The dose effect of ephedrineon the onset time of vecuronium[J].Anesth Analg,2003,96(4):1042-1046.
[27]
[15] Komatsu R,Nagata O,Ozaki M,et al.Ephedrine fails toaccelerate the onset of neuromuscular block by vecuronium[J].Anesth Analg,2003,97(2):480-483.
[29]
[16] Ezri T,Szmuk P,Warters RD,et al.Changes in onset time ofrocuronium in patients pretreated with ephedrine and esmololthe role of cardiac output[J].Acta Anaesthesiol Scand,2003,47(9):1067-1072.

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麻黄碱对维库溴铵预给药方法插管条件的影响

作者简介: 王宏(1972～)，男，博士，副主任医师

1. 1. 蚌埠医学院第一附属医院麻醉科;
2. 2. 安徽省太和县人民医院麻醉科，

录用日期: 2010-09-24
网络出版日期: 2012-04-15

基金项目:

关键词:

摘要: 目的:探讨预注麻黄碱对维库溴铵预给药方法插管条件的影响。方法:60例患者随机分为对照组和麻黄碱组，每组30例，对照组维库溴铵预给药后注入等量生理盐水;麻黄碱组维库溴铵预给药后注入麻黄碱。麻醉诱导后采用Coopers标准行插管条件评分，并记录插管前和插管后5 min患者平均动脉压和心率。结果:麻黄碱组诱导后下颌松弛度评分和插管反应评分均优于对照组(P0.05和P0.01)，声门位置评分2组差异无统计学意义(P0.05)，麻黄碱组30例患者、对照组23例患者诱导后呈现临床可接受的插管条件，差异有统计学意义(P0.05)。麻黄碱组诱导后较对照组有短时间平均动脉压增高和心率增快(P0.05～P0.01)。结论:预注麻黄碱显著改善维库溴铵预给药方法的插管条件。