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缝隙连接作为乳腺癌治疗新靶点的研究进展

蒋国君 童旭辉 祝晓光

引用本文:
Citation:

缝隙连接作为乳腺癌治疗新靶点的研究进展

    作者简介: 蒋国君(1987-),女,硕士研究生
    通讯作者: 祝晓光
  • 基金项目:

    国家自然科学基金资助项目(81001457)

    安徽省优秀青年人才基金重点资助项目(2010SQRL121ZD)

    安徽省教育厅自然科学研究般资助项目(KJ2010B117)

  • 摘要: 乳腺癌是严重威胁女性健康的恶性肿瘤之,其特异性靶向治疗近年来已成为研究的热点。大量研究[1-2]结果表明,肿瘤细胞中的缝隙连接(gap junction,GJ)功能降低,而恢复或增强由连接蛋白(connexin,Cx)所形成的细胞间GJ功能可增强抗肿瘤药物的治疗作用。
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  • 收稿日期:  2011-06-20
  • 刊出日期:  2013-03-15

缝隙连接作为乳腺癌治疗新靶点的研究进展

    通讯作者: 祝晓光
    作者简介: 蒋国君(1987-),女,硕士研究生
  • 1. 蚌埠医学院药理学教研室 安徽蚌埠 233030
基金项目:  国家自然科学基金资助项目(81001457)安徽省优秀青年人才基金重点资助项目(2010SQRL121ZD)安徽省教育厅自然科学研究般资助项目(KJ2010B117)

摘要: 乳腺癌是严重威胁女性健康的恶性肿瘤之,其特异性靶向治疗近年来已成为研究的热点。大量研究[1-2]结果表明,肿瘤细胞中的缝隙连接(gap junction,GJ)功能降低,而恢复或增强由连接蛋白(connexin,Cx)所形成的细胞间GJ功能可增强抗肿瘤药物的治疗作用。

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