缝隙连接作为乳腺癌治疗新靶点的研究进展
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摘要: 乳腺癌是严重威胁女性健康的恶性肿瘤之,其特异性靶向治疗近年来已成为研究的热点。大量研究[1-2]结果表明,肿瘤细胞中的缝隙连接(gap junction,GJ)功能降低,而恢复或增强由连接蛋白(connexin,Cx)所形成的细胞间GJ功能可增强抗肿瘤药物的治疗作用。
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