[2] 杨红,李婕,郭嘉,等.TIMP-3 和 mtp53 在非小细胞肺癌中的表达及意义[J].中国肺癌杂志,2012,15(4):202-207. |
[3] Akcakanat A,Sahin A,Shaye AN,et al.Comparison of Akt/mTOR signaling in primary breast tumors and matched distant metastases[J].Cancer,2008,112(11):2352-2358. |
[4] Liu G,Wheatley-Price P,Zhou W,et al.Genetic polymorphisms of MDM2,cumulative cigarette smoking and nonsmall cell lung cancer risk[J].Int J Cancer,2008,122(4):915-918. |
[5] Zhao E,Cui D,Yuan L,et al.MDM2 SNP309 polymorphism and breast cancer risk:a meta-analysis[J].Mol Biol Rep,2012,39(4):3471-3477. |
[6] Hav M,Libbrecht L,Ferdinande L,et al.MDM2 gene amplification and protein expressions in colon carcinoma:is targeting MDM2 a new therapeutic option[J].Virchows Arch,2011,458(2):197-203. |
[7] Mejia-Guerrero S,Quejada M,Gokgoz N,et al.Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma[J].Genes Chromosomes Cancer,2010,49(6):518-525. |
[8] Zhang MF,Zhang ZY,Fu J,et al.Correlation between expression of p53,p21/ WAF1,and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma[J].J Transl Med,2009,7:110. |
[9] Yamamoto S,Tomita Y,Hoshida Y,et al.Prognostic signifi cance of activated Akt expression in pancreatic ductal adenocarcinoma[J].Clin Cancer Res,2004,10(8):2846-2850. |
[10] Cai Q,Deng H,Xie D,et al.Phosphorylated AKT Protein is overexpressed in Human peripheral t-cell lymphomas and predicts decreased patient survival[J].Clin Lymphoma Myeloma Leuk,2012,12(2):106-112. |
[11] Wang X,Yi L,Zhu Y,et al.AKT signaling pathway in invasive ductal carcinoma of the breast:correlation with ER,ER and HER-2 expression[J].Tumori,2011,97(2):185-190. |
[12] Zhou L,Huang Y,Li J,et al.The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinoma[J].Med Oncol,2010,27(2):255-261. |
[13] Cheng X,Xia W,Yang JY,et al.Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis[J].Cancer Res,2010,70(19):7684-7689. |
[14] de Lima Mde D,Marques YM,Alves Sde M Jr,et al.MDM2,P53,P21WAF1 and pAKT protein levels in genesis and behaviour of adenoid cystic carcinoma [J].Cancer Epidemiol,2009,33(2):142-146. |
[15] Mayo LD,Donner DB.A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of MDM2 from the cytoplasm to the nucleus[J].Proc Natl Acad Sci USA,2001,98 (20):11598-11603. |