-3多不饱和脂肪酸在颅脑外伤并发肺部感染治疗中的应用

刘成; 汪华学; 邹琪

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-3多不饱和脂肪酸在颅脑外伤并发肺部感染治疗中的应用

刘成 , 汪华学 , 邹琪

文章导航 > 蚌埠医学院学报 > 2014, 38 > 1: (55-58)

引用本文:

Citation:

-3多不饱和脂肪酸在颅脑外伤并发肺部感染治疗中的应用

1.
蚌埠医学院第一附属医院ICU, 安徽蚌埠 233004

作者简介: 刘成(1982- ),男,硕士,主治医师,讲师

基金项目:

Role of -3 polyunsaturated fatty acids in treatment of severe brain injuRy accompanied by lung infection

1.
Intensive CaRe Unit, The FiRst Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

摘要: 目的:观察-3多不饱和脂肪酸(-3 PUFAs)在重度颅脑外伤并发肺部感染治疗中的应用效果。方法:将56例重度颅脑外伤并发肺部感染的患者随机分为对照组(A组)和-3 PUFAs组(B组),B组治疗中加用-3 PUFAs。2组患者均完善相关检查,给予抗感染、脱水降颅压等常规治疗,均建立人工气道(气管插管或气管切开)及机械通气,给予能量补充105~125 kJkg-1d-1,其中B组中部分热量由含-3脂肪酸的脂肪乳剂来提供。分别于治疗前及治疗第2、4、7天监测患者当天白细胞计数、C反应蛋白、淋巴细胞亚群分类,并使用ELISA法检测肺泡灌洗液中肿瘤坏死因子-(TNF-)、白细胞介素(IL)-6及IL-10的水平。结果:肺泡灌洗液中TNF-的表达水平在第4、7天B组均明显低于A组(P0.01)。肺泡灌洗液中IL-6的表达水平在第7天B组显著低于A组(P0.01)。肺泡灌洗液中IL-10的表达水平差异无统计学意义(P0.05)。白细胞水平在第4、7天B组均低于A组(P0.01)。CRP水平在第2、4、7天B组均低于A组(P0.01)。CD4/CD8比值在第2、4、7天B组均高于A组(P0.01)。结论:-3 PUFAs能够调节重度颅脑外伤并发肺部感染患者的免疫状态,对肺脏有一定保护作用。
- 感染 /
- 颅脑外伤 /
- -3多不饱和脂肪酸
Abstract: Objective:To obseRve the effect of -3 polyunsatuRated fatty acids in tReatment of seveRe bRain injuRy complicated by lung infection.Methods:Fifty-six cases of seveRe bRain injuRy accompanied by pulmonaRy infection weRe Randomly divided into contRol gRoup(gRoup A) and -3 polyunsatuRated fatty acids gRoup(gRoup B).GRoup B weRe administeRed -3 polyunsatuRated fatty acids in addition to the Routine theRapy.All the patients weRe given Relevant examinations and tReatment such as antibiotics,Reducing the intRacRanial pRessuRe,endotRacheal intubation,ventilatoR application and post-tRacheotomy.Both gRoups weRe given eneRgy supplement 105-125 kJkg-1d-1,but in gRoup B,some of the heat was pRovided by the fat emulsion of -3 polyunsatuRated fatty acids.On the 0th,2 nd,4 th and 7th day,the patients' white blood cell(WBC),C Reactive pRotein(CRP) and lymphocyte subsets classification weRe monitoRed; and the tumoR necRosis factoR-(TNF-),inteRleukin-6(IL-6) and IL-10 weRe tested in the lavage fluid by enzyme linked immunosoRbent assay.Results:The expRession of TNF- in the lavage fluid of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-6 in the lavage fluid of gRoup B on the 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-10 in the lavage fluid of the two gRoups was not statistically diffeRent(P 0.05).The WBC level of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CRP level of gRoup B on the 2nd,4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CD4/CD8 Ratio of gRoup B on the 2nd,4 th and 7th day was significantly higheR than that of the contRol(P 0.01).Conclusions:-3 polyunsatuRated fatty acids can impRove the immunity of patients with seveRe bRain injuRy complicated by lung infection and have a pRotective effect on the lung.
- infection /
- seveRe bRain injuRy /
- -3 polyunsatuRated fatty acids

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-3多不饱和脂肪酸在颅脑外伤并发肺部感染治疗中的应用

作者简介: 刘成(1982- ),男,硕士,主治医师,讲师

1. 蚌埠医学院第一附属医院ICU, 安徽蚌埠 233004

收稿日期: 2012-10-10
网络出版日期: 2014-01-15

基金项目:

关键词:

摘要: 目的:观察-3多不饱和脂肪酸(-3 PUFAs)在重度颅脑外伤并发肺部感染治疗中的应用效果。方法:将56例重度颅脑外伤并发肺部感染的患者随机分为对照组(A组)和-3 PUFAs组(B组),B组治疗中加用-3 PUFAs。2组患者均完善相关检查,给予抗感染、脱水降颅压等常规治疗,均建立人工气道(气管插管或气管切开)及机械通气,给予能量补充105~125 kJkg-1d-1,其中B组中部分热量由含-3脂肪酸的脂肪乳剂来提供。分别于治疗前及治疗第2、4、7天监测患者当天白细胞计数、C反应蛋白、淋巴细胞亚群分类,并使用ELISA法检测肺泡灌洗液中肿瘤坏死因子-(TNF-)、白细胞介素(IL)-6及IL-10的水平。结果:肺泡灌洗液中TNF-的表达水平在第4、7天B组均明显低于A组(P0.01)。肺泡灌洗液中IL-6的表达水平在第7天B组显著低于A组(P0.01)。肺泡灌洗液中IL-10的表达水平差异无统计学意义(P0.05)。白细胞水平在第4、7天B组均低于A组(P0.01)。CRP水平在第2、4、7天B组均低于A组(P0.01)。CD4/CD8比值在第2、4、7天B组均高于A组(P0.01)。结论:-3 PUFAs能够调节重度颅脑外伤并发肺部感染患者的免疫状态,对肺脏有一定保护作用。

English Abstract

Role of -3 polyunsaturated fatty acids in treatment of severe brain injuRy accompanied by lung infection

1. Intensive CaRe Unit, The FiRst Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Received Date: 2012-10-10
Available Online: 2014-01-15

Abstract: Objective:To obseRve the effect of -3 polyunsatuRated fatty acids in tReatment of seveRe bRain injuRy complicated by lung infection.Methods:Fifty-six cases of seveRe bRain injuRy accompanied by pulmonaRy infection weRe Randomly divided into contRol gRoup(gRoup A) and -3 polyunsatuRated fatty acids gRoup(gRoup B).GRoup B weRe administeRed -3 polyunsatuRated fatty acids in addition to the Routine theRapy.All the patients weRe given Relevant examinations and tReatment such as antibiotics,Reducing the intRacRanial pRessuRe,endotRacheal intubation,ventilatoR application and post-tRacheotomy.Both gRoups weRe given eneRgy supplement 105-125 kJkg-1d-1,but in gRoup B,some of the heat was pRovided by the fat emulsion of -3 polyunsatuRated fatty acids.On the 0th,2 nd,4 th and 7th day,the patients' white blood cell(WBC),C Reactive pRotein(CRP) and lymphocyte subsets classification weRe monitoRed; and the tumoR necRosis factoR-(TNF-),inteRleukin-6(IL-6) and IL-10 weRe tested in the lavage fluid by enzyme linked immunosoRbent assay.Results:The expRession of TNF- in the lavage fluid of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-6 in the lavage fluid of gRoup B on the 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the expRession of IL-10 in the lavage fluid of the two gRoups was not statistically diffeRent(P 0.05).The WBC level of gRoup B on the 4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CRP level of gRoup B on the 2nd,4th and 7th day was significantly loweR than that of the contRol gRoup(P 0.01); the CD4/CD8 Ratio of gRoup B on the 2nd,4 th and 7th day was significantly higheR than that of the contRol(P 0.01).Conclusions:-3 polyunsatuRated fatty acids can impRove the immunity of patients with seveRe bRain injuRy complicated by lung infection and have a pRotective effect on the lung.