幽门螺杆菌感染者细胞免疫应答及与胃癌的关系

杨清峰; 江泳; 张旭; 周磊; 张爽

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幽门螺杆菌感染者细胞免疫应答及与胃癌的关系

杨清峰 , 江泳 , 张旭 , 周磊 , 张爽

文章导航 > 蚌埠医学院学报 > 2014, 38 > 2: (190-193)

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幽门螺杆菌感染者细胞免疫应答及与胃癌的关系

1.
安徽省蚌埠市第三人民医院消化内科, 201900
基金项目:
安徽省蚌埠市科技局基金资助项目(200968)

Cellular immune response in gastric lesions associated with Helicobacter pylori infection and its correlation with gastric cancer

1.
Department of Gastroenterology, Bengbu Third People's Hospital, Bengbu Anhui 233000, China

摘要: 目的：探讨幽门螺杆菌(Hp)感染时不同疾病宿主Th1/Th2细胞免疫应答变化及与胃癌发生的相关性。方法：采用酶联免疫吸附法测定浅表性胃炎、胃癌前病变和胃癌患者血清干扰素(IFN-)及白细胞介素-4(IL-4)的水平,同时采用免疫组织化学方法检测3种疾病患者胃黏膜病变局部IFN-及IL-4的表达情况。结果:Hp阳性的浅表性胃炎患者血清IL-4水平较Hp阴性的浅表性胃炎患者明显降低(P0.01);Hp阳性的浅表性胃炎、胃癌前病变及胃癌患者血清IL-4水平随病变的进展有逐渐升高的趋势,但3组间差异均无统计学意义(P0.05),血清IFN-水平亦均无明显不同(P0.05)。免疫组织化学检测发现IFN-在Hp感染的浅表性胃炎中表达较高(P0.05),IL-4的表达与之相反,在Hp感染的胃癌组织中表达较高(P0.05)。结论：胃病变局部Th1/Th2细胞免疫应答变化与Hp感染相关疾病的进展,特别是胃癌的发生密切相关。
- 胃疾病 /
- 幽门螺杆菌 /
- 辅助性T细胞 /
- 胃癌 /
- 干扰素- /
- 白细胞介素-4
Abstract: Objective: To investigate the change of Th1 /Th2 cellular immune response in patients with gastric lesions associated with Helicobacter pylori(Hp) infection and its correlation with the genesis of gastric cancer. Methods: Enzyme linked immunosorbent assay was employed Objective: To determine the levels of serum -interferon (IFN-) and interleukin-4 (IL-4 ) in patients with chronic superficial gastritis(CSG),preneoplastic gastric diseases(PGD) and gastric cancer(GC). At the same time， immunohisObjective: Tochemisty staining was employed Objective: To determine the expression of IFN- and IL-4 in the gastric biopsies of the 3 groups. Results: The level of serum IL-4 in CSG with Hp infection was lower than that without Hp infection(P ＜ 0. 01) ; the level of serum IL-4 was elevated along with the progression of pathological changes in the cases of CSG，PGD and GC with Hp infection，but the difference was not significant among the three groups(P ＞ 0. 05),and the difference in the level of serum IFN- was not significant among the three groups， Objective: Too(P ＞ 0. 05). The immunohisObjective: Tochemisty staining showed high expression of IFN- in the inflammation biopsies with Hp infection(P ＜ 0. 05) ; and the expression of IL-4 was high in the gastric cancer biopsies with Hp infection(P ＜ 0. 05). Conclusions: Local Th1 /Th2 cellular immune response has correlation with the progression of pathological changes in patients with Hp infection，especially in patients with gastric cancer.
- stomach diseases /
- Helicobacter pylori /
- helper T cell /
- gastric cancer /
- gamma interferon /
- interleukin-4

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幽门螺杆菌感染者细胞免疫应答及与胃癌的关系

1. 安徽省蚌埠市第三人民医院消化内科, 201900

收稿日期: 2013-05-09
网络出版日期: 2014-02-15

基金项目: 安徽省蚌埠市科技局基金资助项目(200968)

关键词:

摘要: 目的：探讨幽门螺杆菌(Hp)感染时不同疾病宿主Th1/Th2细胞免疫应答变化及与胃癌发生的相关性。方法：采用酶联免疫吸附法测定浅表性胃炎、胃癌前病变和胃癌患者血清干扰素(IFN-)及白细胞介素-4(IL-4)的水平,同时采用免疫组织化学方法检测3种疾病患者胃黏膜病变局部IFN-及IL-4的表达情况。结果:Hp阳性的浅表性胃炎患者血清IL-4水平较Hp阴性的浅表性胃炎患者明显降低(P0.01);Hp阳性的浅表性胃炎、胃癌前病变及胃癌患者血清IL-4水平随病变的进展有逐渐升高的趋势,但3组间差异均无统计学意义(P0.05),血清IFN-水平亦均无明显不同(P0.05)。免疫组织化学检测发现IFN-在Hp感染的浅表性胃炎中表达较高(P0.05),IL-4的表达与之相反,在Hp感染的胃癌组织中表达较高(P0.05)。结论：胃病变局部Th1/Th2细胞免疫应答变化与Hp感染相关疾病的进展,特别是胃癌的发生密切相关。

English Abstract

Cellular immune response in gastric lesions associated with Helicobacter pylori infection and its correlation with gastric cancer

1. Department of Gastroenterology, Bengbu Third People's Hospital, Bengbu Anhui 233000, China

Received Date: 2013-05-09
Available Online: 2014-02-15

Abstract: Objective: To investigate the change of Th1 /Th2 cellular immune response in patients with gastric lesions associated with Helicobacter pylori(Hp) infection and its correlation with the genesis of gastric cancer. Methods: Enzyme linked immunosorbent assay was employed Objective: To determine the levels of serum -interferon (IFN-) and interleukin-4 (IL-4 ) in patients with chronic superficial gastritis(CSG),preneoplastic gastric diseases(PGD) and gastric cancer(GC). At the same time， immunohisObjective: Tochemisty staining was employed Objective: To determine the expression of IFN- and IL-4 in the gastric biopsies of the 3 groups. Results: The level of serum IL-4 in CSG with Hp infection was lower than that without Hp infection(P ＜ 0. 01) ; the level of serum IL-4 was elevated along with the progression of pathological changes in the cases of CSG，PGD and GC with Hp infection，but the difference was not significant among the three groups(P ＞ 0. 05),and the difference in the level of serum IFN- was not significant among the three groups， Objective: Too(P ＞ 0. 05). The immunohisObjective: Tochemisty staining showed high expression of IFN- in the inflammation biopsies with Hp infection(P ＜ 0. 05) ; and the expression of IL-4 was high in the gastric cancer biopsies with Hp infection(P ＜ 0. 05). Conclusions: Local Th1 /Th2 cellular immune response has correlation with the progression of pathological changes in patients with Hp infection，especially in patients with gastric cancer.

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幽门螺杆菌感染者细胞免疫应答及与胃癌的关系

Cellular immune response in gastric lesions associated with Helicobacter pylori infection and its correlation with gastric cancer

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幽门螺杆菌感染者细胞免疫应答及与胃癌的关系

English Abstract

Cellular immune response in gastric lesions associated with Helicobacter pylori infection and its correlation with gastric cancer

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