CXCL12/CXCR4信号通路及其与肿瘤关系的研究进展
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摘要: 趋化因子是一类结构相似,对某些细胞具有趋化作用的小分子蛋白质。趋化因子12(CXCL12)及其受体(CXCR4)在许多生理和病理过程中发挥重要作用,在肿瘤中通过几个不同途径使细胞内信号发生改变,能够促进肿瘤细胞增殖、运动、黏附、侵袭、转移和分泌等,影响着肿瘤的发生、发展和预后。本文就近年来CXCL12/CXCR4研究进展作一综述。1 CXCL12与CXCR4的结构及生物学功能趋化因子是由一组相对分子量在8 000~12 000的小分子细胞因子组成的具有化学趋化性的细胞因子大家族,是对
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