Abstract: Objective: To evaluate the effect of sufentanil in combination with propofol as general anesthesia induction on the hemodynamic response during tracheal intubation period.Methods: Forty patients with ASA Ⅰ-Ⅱ stages laparoscopic cholecystectomy were randomized into 2 groups,sufentanil group and fentanyl group,20 cases of each group.Anesthesia induction were done through intravenous injection with midazolam at 0.05 mg/kg,propofol at 1-1.5 mg/kg,sufentanil at 0.5 μg/kg or fentanyl at 3-5 μg/kg,vecuronium at 0.1 mg/kg.Five minutes later,tracheal intubation was done.The hemodynamics before induction,during induction and 5 min after intubation were recorded.Results: In fentanyl group,in contrast to before induction,mean arterial pressure(MAP) and heart rate(HR) had more significant differences after anesthesia induction(P<0.01).In Sufentanil group,these parameters had no significant difference(P>0.05).Between the two groups within 5 min after intubation,MAP and HR had significant differences(P<0.01).Conclusions: Sufentanil in combination with propofol as general anesthesia induction is more stable and less stress response on blood hemodynamics.