缺血性脑血管病患者同型半胱氨酸和基质金属蛋白酶-9与颈动脉粥样硬化的关系

余传庆; 张梅; 薛敏

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缺血性脑血管病患者同型半胱氨酸和基质金属蛋白酶-9与颈动脉粥样硬化的关系

余传庆 , 张梅 , 薛敏

文章导航 > 蚌埠医学院学报 > 2011, 36 > 8: (831-834,836)

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缺血性脑血管病患者同型半胱氨酸和基质金属蛋白酶-9与颈动脉粥样硬化的关系

安徽省淮南市第一人民医院神经内科, 232007

作者简介: 余传庆(1967-),男,副主任医师.

基金项目:
安徽省2008年度科研计划资助项目(08020303069)
中图分类号: R743.3

Relationship between the levels of plasma homocysteine,matrix metalloproteinase-9 and carotid atherosclerosis in patients with ischemic cerebrovascular disease

Department of Neurology, Huainan First People's Hospital, Huainan Anhui 232007, China
CLC number: R743.3

摘要: 目的: 探讨缺血性脑血管病(ICVD)患者同型半胱氨酸(Hcy)和基质金属蛋白酶-9(MMP-9)与颈动脉粥样硬化(CAS)斑块及其硬化程度的关系。方法: 240例确诊的ICVD患者(ICVD组,又分为有CAS斑块组123例和无CAS斑块组117例)和236例非脑血管病患者(对照组),均接受颈动脉超声检查,检测颈动脉内膜中层厚度(IMT)状况,并对血浆Hcy和MMP-9水平与CAS的斑块及其硬化程度分型进行相关性分析。结果: ICVD患者Hcy和MMP-9水平均明显高于对照组(P < 0.01),ICVD患者斑块组Hcy和MMP-9水平均明显高于无斑块组(P < 0.01)。ICVD组颈动脉IMT与Hcy和MMP-9水平呈正相关关系(P < 0.05);ICVD组颈动脉硬化程度与Hcy及MMP-9水平呈正相关关系(P < 0.05);ICVD组血浆Hcy与MMP-9水平呈正相关关系(P < 0.01)。高龄、高血压、高脂血症、糖尿病、吸烟、饮酒及冠心病对ICVD动脉粥样硬化斑块的形成影响较大。结论: ICVD患者中,CAS斑块形成可能与血浆Hcy和MMP-9升高有关,CAS程度愈高,其相关性愈大,ICVD患者Hcy和MMP-9水平可以反映颈动脉斑块的性质和稳定性,是临床了解ICVD严重程度的重要指标。
- 脑血管意外 /
- 同型半胱氨酸 /
- 基质金属蛋白酶-9 /
- 颈动脉粥样硬化
Abstract: Objective: To investigate the relationship between the levels of plasma homocysteine(Hcy),matrix metalloproteinase-9 (MMP-9) and carotid atherosclerosis(CAS) in patients with ischemic cerebrovascular disease(IVCD). Methods: Two hundred and forty patients with IVCD (IVCD group) and 236 patients without cerebrovascular diseases (control group) received carotid ultrasonograph to detect the intima-media thickness(IMT) of the carotid artery. The correlation analysis was made between the levels of Hcy,MMP-9 and CAS plaque and its degree. Results: The levels of Hcy and MMP-9 in IVCD group were significantly higher than those in control group(P < 0.01); the levels of Hcy and MMP-9 in IVCD group with carotid atherosclerotic plaque were significantly higher than that in control group(P < 0.01); the IMT was positively correlated with the level of Hcy and MMP-9 in IVCD group(P < 0.05); the degree of CAS was positively correlated with the level of Hcy and MMP-9 in IVCD group(P < 0.05); the level of Hcy was positively correlated with that of MMP-9 in IVCD group(P < 0.01). Age,hypertension,hyperlipidemia,diabetes,smoke,drink and coronary artery disease were important risk factors for formation of CAS plaque. Conclusions: The formation of CAS plaque may be closely associated with the level of Hcy and MMP-9 in patients with IVCD. There is higher degree of CAS,the more correlation between CAS and Hcy or MMP-9. The levels of Hcy and MMP-9 in patients with IVCD may reflect the character and stability of carotid artery plaque,and they can be important indicators about the severity of IVCD for clinical practice.
- ischemic cerebrovascular disease /
- homocysteine /
- matrix metalloproteinase-9 /
- carotid atherosclerosis

[1]	白艳华 , 柯建乐 . 腔隙性脑梗死病人颈动脉粥样硬化与血同型半胱氨酸关系及其危险因素研究. 蚌埠医学院学报, 2021, 46(3): 325-327, 331. doi: 10.13898/j.cnki.issn.1000-2200.2021.03.012
[2]	李有中 , 郑重 , 谢康 . 动脉粥样硬化性脑梗死病人胱抑素C、同型半胱氨酸、超敏C反应蛋白和D-二聚体联合检测的临床意义. 蚌埠医学院学报, 2018, 43(5): 589-591. doi: 10.13898/j.cnki.issn.1000-2200.2018.05.007
[3]	郁佳 , 陶黎明 , 汪万英 , 李杨 . 基质金属蛋白酶-9和血管内皮生长因子在视网膜母细胞瘤中的表达及其临床意义. 蚌埠医学院学报, 2009, 34(4): 298-301.
[4]	仵志远 , 姜德清 , 郝占伟 . CD147和基质金属蛋白酶-9在肝细胞肝癌中的表达与微血管生成的相关性. 蚌埠医学院学报, 2015, 40(4): 450-452,455. doi: 10.13898/j.cnki.issn.1000-2200.2015.04.010
[5]	孙卫华 , 张晓梅 , 李晓丽 , 时照明 , 裴晓艳 , 吴道爱 . 同型半胱氨酸和C反应蛋白与2型糖尿病大血管病变的关系研究. 蚌埠医学院学报, 2014, 39(7): 852-854.
[6]	耿旭 , 马宾 , 王洪巨 , 张恒 , 李妙男 , 康品方 . 同型半胱氨酸及高敏C反应蛋白与冠状动脉病变程度的关系. 蚌埠医学院学报, 2017, 42(5): 587-590. doi: 10.13898/j.cnki.issn.1000-2200.2017.05.008
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[8]	傅毅 , 陈生弟 , 马飞月 . 脑血管病患者血浆同型半胱氨酸浓度及相关因素分析. 蚌埠医学院学报, 2004, 29(2): 151-153.
[9]	周继红 , 章尧 . 同型半胱氨酸对血管内皮细胞凋亡和核因子-κB活化的影响. 蚌埠医学院学报, 2011, 36(2): 117-120.
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[11]	董少军 , 马锐 , 吴承志 . 中青年脑梗死患者血清同型半胱氨酸水平与颈动脉硬化的关系. 蚌埠医学院学报, 2009, 34(3): 209-211.
[12]	姚晴宇 , 许著一 , 孙杨 . 血浆同型半胱氨酸与脑皮质下小血管病变的相关性研究. 蚌埠医学院学报, 2015, 40(1): 71-72,76. doi: 10.13898/j.cnki.issn.1000-2200.2015.01.023
[13]	朱方方 , 张友好 , 冯敏 , 钱伟东 . 同型半胱氨酸、超敏C反应蛋白、低密度脂蛋白、三酰甘油、总胆固醇与急性脑梗死的关系研究. 蚌埠医学院学报, 2016, 41(5): 623-625. doi: 10.13898/j.cnki.issn.1000-2200.2016.05.022
[14]	常丽 , 黄莹芝 . 2型糖尿病血清同型半胱氨酸、视黄醇结合蛋白与尿微量白蛋白/肌酐比值的相关性分析. 蚌埠医学院学报, 2023, 48(10): 1395-1398. doi: 10.13898/j.cnki.issn.1000-2200.2023.10.015
[15]	王敏 , 汪春华 , 刘群 , 徐转 . 同型半胱氨酸、N端脑钠肽前体及超敏C反应蛋白在缺血性脑卒中患者中的临床价值. 蚌埠医学院学报, 2014, 39(7): 956-959.
[16]	孙伟 , 王飞 , 朱江 , 靳辉 . 2型糖尿病合并脑梗死患者血清同型半胱氨酸、纤维蛋白原水平的变化. 蚌埠医学院学报, 2015, 39(7): 876-878. doi: 10.13898/j.cnki.issn.1000-2200.2015.07.013
[17]	周玉森 , 马景贺 . 血清同型半胱氨酸和高敏C反应蛋白浓度与脑梗死面积关系. 蚌埠医学院学报, 2009, 34(5): 407-409.
[18]	王勇 . 脑梗死患者检测超敏C反应蛋白和同型半胱氨酸的临床意义. 蚌埠医学院学报, 2014, 39(9): 1280-1282.
[19]	刘桂凌 , 张伯科 , 陈卫东 . 慢性肾衰竭患者并发脑血管意外与超敏C-反应蛋白的关系. 蚌埠医学院学报, 2007, 32(6): 652-653,656.
[20]	田玲 , 万敏 , 王倩 , 柏妍槟 , 沈禾 , 闫华 . 基质金属蛋白酶-9、Ⅲ型胶原、纤维黏连蛋白在胎膜早破发病机制中的作用. 蚌埠医学院学报, 2018, 43(7): 907-911. doi: 10.13898/j.cnki.issn.1000-2200.2018.07.018

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缺血性脑血管病患者同型半胱氨酸和基质金属蛋白酶-9与颈动脉粥样硬化的关系

作者简介: 余传庆(1967-),男,副主任医师.

安徽省淮南市第一人民医院神经内科, 232007

收稿日期: 2010-09-26

基金项目: 安徽省2008年度科研计划资助项目(08020303069)

关键词:

摘要: 目的: 探讨缺血性脑血管病(ICVD)患者同型半胱氨酸(Hcy)和基质金属蛋白酶-9(MMP-9)与颈动脉粥样硬化(CAS)斑块及其硬化程度的关系。方法: 240例确诊的ICVD患者(ICVD组,又分为有CAS斑块组123例和无CAS斑块组117例)和236例非脑血管病患者(对照组),均接受颈动脉超声检查,检测颈动脉内膜中层厚度(IMT)状况,并对血浆Hcy和MMP-9水平与CAS的斑块及其硬化程度分型进行相关性分析。结果: ICVD患者Hcy和MMP-9水平均明显高于对照组(P < 0.01),ICVD患者斑块组Hcy和MMP-9水平均明显高于无斑块组(P < 0.01)。ICVD组颈动脉IMT与Hcy和MMP-9水平呈正相关关系(P < 0.05);ICVD组颈动脉硬化程度与Hcy及MMP-9水平呈正相关关系(P < 0.05);ICVD组血浆Hcy与MMP-9水平呈正相关关系(P < 0.01)。高龄、高血压、高脂血症、糖尿病、吸烟、饮酒及冠心病对ICVD动脉粥样硬化斑块的形成影响较大。结论: ICVD患者中,CAS斑块形成可能与血浆Hcy和MMP-9升高有关,CAS程度愈高,其相关性愈大,ICVD患者Hcy和MMP-9水平可以反映颈动脉斑块的性质和稳定性,是临床了解ICVD严重程度的重要指标。

English Abstract

Relationship between the levels of plasma homocysteine,matrix metalloproteinase-9 and carotid atherosclerosis in patients with ischemic cerebrovascular disease

Department of Neurology, Huainan First People's Hospital, Huainan Anhui 232007, China

Received Date: 2010-09-26

Abstract: Objective: To investigate the relationship between the levels of plasma homocysteine(Hcy),matrix metalloproteinase-9 (MMP-9) and carotid atherosclerosis(CAS) in patients with ischemic cerebrovascular disease(IVCD). Methods: Two hundred and forty patients with IVCD (IVCD group) and 236 patients without cerebrovascular diseases (control group) received carotid ultrasonograph to detect the intima-media thickness(IMT) of the carotid artery. The correlation analysis was made between the levels of Hcy,MMP-9 and CAS plaque and its degree. Results: The levels of Hcy and MMP-9 in IVCD group were significantly higher than those in control group(P < 0.01); the levels of Hcy and MMP-9 in IVCD group with carotid atherosclerotic plaque were significantly higher than that in control group(P < 0.01); the IMT was positively correlated with the level of Hcy and MMP-9 in IVCD group(P < 0.05); the degree of CAS was positively correlated with the level of Hcy and MMP-9 in IVCD group(P < 0.05); the level of Hcy was positively correlated with that of MMP-9 in IVCD group(P < 0.01). Age,hypertension,hyperlipidemia,diabetes,smoke,drink and coronary artery disease were important risk factors for formation of CAS plaque. Conclusions: The formation of CAS plaque may be closely associated with the level of Hcy and MMP-9 in patients with IVCD. There is higher degree of CAS,the more correlation between CAS and Hcy or MMP-9. The levels of Hcy and MMP-9 in patients with IVCD may reflect the character and stability of carotid artery plaque,and they can be important indicators about the severity of IVCD for clinical practice.