ω-3多不饱和脂肪酸在治疗重度颅脑外伤并发肺部感染中的临床应用

刘成; 张泓

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ω-3多不饱和脂肪酸在治疗重度颅脑外伤并发肺部感染中的临床应用

刘成 , 张泓

文章导航 > 蚌埠医学院学报 > 2011, 36 > 12: (1322-1324,1327)

引用本文:

Citation:

ω-3多不饱和脂肪酸在治疗重度颅脑外伤并发肺部感染中的临床应用

刘成^1,2,
张泓¹

1. 安徽医科大学第一附属医院急诊内科, 安徽合肥 230032;
2. 蚌埠医学院第一附属医院ICU, 安徽蚌埠 233004

作者简介: 刘成(1982-),男,硕士研究生,住院医师.

中图分类号: R631

Clinical application of ω-3 polyunsaturated fatty acids in severe brain injury complicated by lung infection

LIU Cheng^1,2,
ZHANG Hong¹

1. Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei Anhui 230032;
2. ICU, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China
CLC number: R631

摘要: 目的:观察ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)在重度颅脑外伤并发肺部感染治疗中的应用效果。方法:将56例重度颅脑外伤并发肺部感染的患者随机均分为对照组和干预组,干预组在对照组治疗的基础上加用ω-3PUFAs。2组患者均完善相关检查,常规治疗为抗感染、脱水降颅压等,均建立人工气道(气管插管或气管切开)及机械通气,均给予能量补充105~125 kJ·kg^-1·d^-1,干预组中部分热量由ω-3PUFAs的脂肪乳剂来提供。分别于治疗前及治疗第2、4、7天监测患者当日最高体温、呼吸频率、心率、白细胞计数及氧合指数,比较2组患者的预后、ICU停留时间、呼吸机使用时间和ICU期间的费用。结果:2组的临床指标在第2天比较差异无统计学意义(P>0.05);2组患者的生命体征和白细胞计数均呈下降趋势,氧合指数呈上升趋势,与时间呈相关性,干预组在第4和7天较对照组更明显,差异均有统计学意义(P<0.05~P<0.01);第7天观察患者预后转归,2组差异无统计学意义(P>0.05);在呼吸机使用时间、ICU停留时间及费用差异均有统计学意义(P<0.01)。结论:ω-3PUFAs对重度颅脑外伤并发肺部感染患者机体有一定的保护作用。
- 肺部感染 /
- 颅脑外伤 /
- ω-3多不饱和脂肪酸
Abstract: Objective:To observe therapy effect of ω-3 polyunsaturated fatty acids in severe brain injury complicated by lung infection. Methods:Fifty-six cases of severe brain injury in patients with pulmonary infection were randomly divided into control group and Ewing group. Before division, all the patients were given the relevant examination and treatments such as antibiotics, reducing intracranial pressure,as well as endotracheal intubation, ventilator application and post-tracheotomy. Both groups were given energy supplement 105~125 kJ·kg^-1·d^-1,but in Ewing group,some of the heat were provided by the fat emulsion of ω-3 fatty acids. On the 0th,2nd,4th and 7th day patients'maximum day temperature,respiratory rate,heart rate,white blood cell,oxygenation index were monitored,and finally prognosis,ICU stay time,ventilation time and an average cost of the two groups of patients during ICU stay time were recorded. Results:The control group and Ewing group with positive anti-infection treatments are getting better. Clinical indicators of Ewing group and the control group on the 2nd day were not statistically significant(P>0.05). The vital signs(temperature,heart rate,respiration) and white blood cells of the two groups of patients showed downward trend over time,while the oxygenation index showed an upward trend over time,which is more significant for Ewing group on the 4th and 7th day compared with the control group, and the difference was statistically significant(P<0.05-P<0.01). After the 7-day observation in the prognosis outcome,the two groups showed no significant differences,not statistically significant(P>0.05). However,in the average ventilator time,ICU length of stay and cost,the two groups has significant differences,with statistical significance(P<0.01). Conclusions:ω-3 polyunsaturated fatty acids on severe brain injury in patients with pulmonary infection in the body has a protective effect.
- severe brain injury /
- lung infection /
- ω-3 polyunsaturated fatty acids

[1]	刘成 , 汪华学 , 邹琪 . -3多不饱和脂肪酸在颅脑外伤并发肺部感染治疗中的应用. 蚌埠医学院学报, 2014, 38(1): 55-58.
[2]	罗志建 . 重症监护室重型颅脑损伤致肺部感染的临床用药分析. 蚌埠医学院学报, 2015, 40(8): 1020-1022. doi: 10.13898/j.cnki.issn.1000-2200.2015.08.011
[3]	余刚 , 何先弟 . ω-3多不饱和脂肪酸对脓毒血症急性肺损伤大鼠肺组织中核因子κB表达的影响. 蚌埠医学院学报, 2011, 36(4): 329-331.
[4]	曾丽 , 姚惠 . 家庭跟进服务模式对颅脑外伤病人术后康复的影响. 蚌埠医学院学报, 2018, 43(1): 117-120. doi: 10.13898/j.cnki.issn.1000-2200.2018.01.035
[5]	周桂红 . 高压氧早期综合治疗对颅脑外伤病人免疫功能及预后的影响. 蚌埠医学院学报, 2018, 43(7): 877-881. doi: 10.13898/j.cnki.issn.1000-2200.2018.07.010
[6]	徐春林 , 冯石萍 , 罗杰 , 熊学辉 , 胡均贤 . 颅脑外伤患者躁动原因分析及应用镇静药物后呼吸频率、血氧分压及平均动脉压情况观察. 蚌埠医学院学报, 2017, 42(2): 172-174,178. doi: 10.13898/j.cnki.issn.1000-2200.2017.02.011
[7]	张向农 . 急性脑卒中并发肺部感染45例临床分析. 蚌埠医学院学报, 2008, 33(4): 421-422.
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[11]	王涛 , 郑洪洪 , 徐志新 . 老年髋部骨折病人不同危险因素对围术期发生肺部感染的影响. 蚌埠医学院学报, 2018, 43(7): 882-885. doi: 10.13898/j.cnki.issn.1000-2200.2018.07.011
[12]	蔡长霞 , 甘桂芬 , 牛毅 , 赵海燕 . 老年心力衰竭合并肺部感染病人病原学分析及预后. 蚌埠医学院学报, 2019, 44(3): 363-365. doi: 10.13898/j.cnki.issn.1000-2200.2019.03.024
[13]	陈娜娜 , 叶枫林 , 姚琳 , 葛树阳 . 震动排痰机在食管癌术后并发肺部感染患者中的应用. 蚌埠医学院学报, 2012, 36(11): 1368-1369.
[14]	应德琴 , 徐丹 . 不同吸痰方式对ICU肺部感染病人吸痰效果及呼吸功能的影响. 蚌埠医学院学报, 2019, 44(3): 343-345. doi: 10.13898/j.cnki.issn.1000-2200.2019.03.018
[15]	许克路 , 沈勤 , 柏耀林 , 冯传江 . 腰丛阻滞复合不同麻醉深度喉罩全麻在老年THA围手术期的应用. 蚌埠医学院学报, 2021, 46(8): 1017-1022. doi: 10.13898/j.cnki.issn.1000-2200.2021.08.008
[16]	汪华学 , 何先弟 , 吴强 , 郑胜永 , 赵飞 , 刘成 . 添加ω-3脂肪酸的全肠外营养对闭合性腹部外伤重症患者的影响. 蚌埠医学院学报, 2009, 34(7): 570-572.
[17]	郑夏林 , 张少军 , 韩易 , 刘后银 . 颅脑外伤后急性脑肿胀的外科救治. 蚌埠医学院学报, 2013, 37(12): 1607-1608.
[18]	王永志 , 冯东福 . 骨髓基质细胞治疗颅脑外伤的研究进展. 蚌埠医学院学报, 2010, 35(3): 313-315.
[19]	张潜 , 李光远 . 颅脑外伤后进展性出血损伤46例诊治分析. 蚌埠医学院学报, 2010, 35(12): 1255-1256,1259.
[20]	高宏斌 , 王武斌 , 汤加才 , 朱国庆 , 刘铭 . 终池置管持续引流治疗脑外伤术后脑脊液漏伴颅内感染. 蚌埠医学院学报, 2008, 33(3): 308-310.

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ω-3多不饱和脂肪酸在治疗重度颅脑外伤并发肺部感染中的临床应用

刘成^1,2
张泓¹

作者简介: 刘成(1982-),男,硕士研究生,住院医师.

1. 安徽医科大学第一附属医院急诊内科, 安徽合肥 230032;
2. 蚌埠医学院第一附属医院ICU, 安徽蚌埠 233004

收稿日期: 2011-08-12

关键词:

摘要: 目的:观察ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)在重度颅脑外伤并发肺部感染治疗中的应用效果。方法:将56例重度颅脑外伤并发肺部感染的患者随机均分为对照组和干预组,干预组在对照组治疗的基础上加用ω-3PUFAs。2组患者均完善相关检查,常规治疗为抗感染、脱水降颅压等,均建立人工气道(气管插管或气管切开)及机械通气,均给予能量补充105~125 kJ·kg^-1·d^-1,干预组中部分热量由ω-3PUFAs的脂肪乳剂来提供。分别于治疗前及治疗第2、4、7天监测患者当日最高体温、呼吸频率、心率、白细胞计数及氧合指数,比较2组患者的预后、ICU停留时间、呼吸机使用时间和ICU期间的费用。结果:2组的临床指标在第2天比较差异无统计学意义(P>0.05);2组患者的生命体征和白细胞计数均呈下降趋势,氧合指数呈上升趋势,与时间呈相关性,干预组在第4和7天较对照组更明显,差异均有统计学意义(P<0.05~P<0.01);第7天观察患者预后转归,2组差异无统计学意义(P>0.05);在呼吸机使用时间、ICU停留时间及费用差异均有统计学意义(P<0.01)。结论:ω-3PUFAs对重度颅脑外伤并发肺部感染患者机体有一定的保护作用。

English Abstract

Clinical application of ω-3 polyunsaturated fatty acids in severe brain injury complicated by lung infection

LIU Cheng^1,2
ZHANG Hong¹

1. Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei Anhui 230032;
2. ICU, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Received Date: 2011-08-12

Abstract: Objective:To observe therapy effect of ω-3 polyunsaturated fatty acids in severe brain injury complicated by lung infection. Methods:Fifty-six cases of severe brain injury in patients with pulmonary infection were randomly divided into control group and Ewing group. Before division, all the patients were given the relevant examination and treatments such as antibiotics, reducing intracranial pressure,as well as endotracheal intubation, ventilator application and post-tracheotomy. Both groups were given energy supplement 105~125 kJ·kg^-1·d^-1,but in Ewing group,some of the heat were provided by the fat emulsion of ω-3 fatty acids. On the 0th,2nd,4th and 7th day patients'maximum day temperature,respiratory rate,heart rate,white blood cell,oxygenation index were monitored,and finally prognosis,ICU stay time,ventilation time and an average cost of the two groups of patients during ICU stay time were recorded. Results:The control group and Ewing group with positive anti-infection treatments are getting better. Clinical indicators of Ewing group and the control group on the 2nd day were not statistically significant(P>0.05). The vital signs(temperature,heart rate,respiration) and white blood cells of the two groups of patients showed downward trend over time,while the oxygenation index showed an upward trend over time,which is more significant for Ewing group on the 4th and 7th day compared with the control group, and the difference was statistically significant(P<0.05-P<0.01). After the 7-day observation in the prognosis outcome,the two groups showed no significant differences,not statistically significant(P>0.05). However,in the average ventilator time,ICU length of stay and cost,the two groups has significant differences,with statistical significance(P<0.01). Conclusions:ω-3 polyunsaturated fatty acids on severe brain injury in patients with pulmonary infection in the body has a protective effect.