宫颈鳞癌中RECK与MMP-9的表达及意义

张运彩; 赵锦; 李胜泽

doi:10.13898/j.cnki.issn.1000-2200.2016.09.026

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宫颈鳞癌中RECK与MMP-9的表达及意义

张运彩 , 赵锦 , 李胜泽

文章导航 > 蚌埠医学院学报 > 2016, 41 > 9: (1201-1204)

引用本文:

Citation:

宫颈鳞癌中RECK与MMP-9的表达及意义

1. 安徽省蚌埠市第一人民医院妇产科, 233000;
2. 蚌埠医学院第一附属医院肿瘤妇科, 安徽蚌埠 233004

作者简介: 张运彩(1974-),女,硕士,主治医师.

中图分类号: R737.33

Expression and significance of RECK and MMP-9 in cervical squamous cell carcinoma

1. Department of Gynecology and Obstetrics, The First People's Hospital of Bengbu, Bengbu Anhui 233000;
2. Department of Gynecological Tumor, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China
CLC number: R737.33

摘要: 目的：探讨宫颈鳞癌中逆转录富含半胱氨酸蛋白（RECK）和基质金属蛋白酶（MMP）-9的表达及意义。方法：应用免疫组织化学法，检测20例正常子宫颈组织及70例子宫颈鳞状细胞癌中RECK和MMP-9的表达。结果：RECK蛋白在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为95.00%和31.43%，差异有统计学意义（P<0.01）；有淋巴转移组的阳性率较无淋巴转移组明显降低（P<0.01）。MMP-9在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为25.00%和80.00%，差异亦有统计学意义（P<0.01）；MMP-9表达在宫颈鳞癌有淋巴转移组的阳性率较无淋巴转移组明显升高（P<0.01）。RECK及MMP-9在宫颈鳞癌中的表达呈负相关关系（P<0.01）。结论：RECK在宫颈鳞癌中表达减少或缺失可能是通过上调MMP-9的表达从而促进宫颈鳞癌的侵袭与转移,RECK和MMP-9与宫颈鳞癌的浸润转移密切相关。
- 宫颈肿瘤 /
- 逆转录富含半胱氨酸蛋白 /
- 基质金属蛋白酶-9
Abstract: Objective: To investigate the expressions and significance of RECK and matrixmetalloproteinase-9(MMP-9) in the cervical squamous cell carcinoma.Methods: The expressions of RECK and MMP-9 in 20 cases of normal cervical tissue and 70 cases of cervical squamous cell carcinoma were detected using immune histochemical staining method.Results: The positive rates of RECK protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 95.00% and 31.43%,respectively,the difference of which was statistically significant(P<0.01).Compared with the cervical squamous cell carcinoma patients without lymph node metastasis,the positive rate of RECK in patients with lymph node metastasis significantly decreased(P<0.01).The positive rates of MMP-9 protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 25.00% and 80.00%,respectively,the difference of which was statistically significant(P<0.01).Compared with the cervical squamous cell carcinoma patients without lymph node metastasis,the positive rate of MMP-9 in patients with lymph node metastasis significantly increased(P<0.01).The expression of RECK in cervical squamous carcinoma was negative correlation with the expression of MMP-9(P<0.01).Conclusions: The decreasing or absent of the RECK expression in cervical squamous carcinoma maybe though upregulate the expression of MMP-9 to promote the infiltration and metastasis of cervical squamous carcinoma.The RECK and MMP-9 are closely related to the infiltration and metastasis.
- cervical neoplasms /
- reversion-inducing-cyste-ine-rich protein with kazal motifs /
- matrixmetalloproteinase-9

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宫颈鳞癌中RECK与MMP-9的表达及意义

作者简介: 张运彩(1974-),女,硕士,主治医师.

1. 安徽省蚌埠市第一人民医院妇产科, 233000;
2. 蚌埠医学院第一附属医院肿瘤妇科, 安徽蚌埠 233004

收稿日期: 2015-10-31

关键词:

摘要: 目的：探讨宫颈鳞癌中逆转录富含半胱氨酸蛋白（RECK）和基质金属蛋白酶（MMP）-9的表达及意义。方法：应用免疫组织化学法，检测20例正常子宫颈组织及70例子宫颈鳞状细胞癌中RECK和MMP-9的表达。结果：RECK蛋白在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为95.00%和31.43%，差异有统计学意义（P<0.01）；有淋巴转移组的阳性率较无淋巴转移组明显降低（P<0.01）。MMP-9在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为25.00%和80.00%，差异亦有统计学意义（P<0.01）；MMP-9表达在宫颈鳞癌有淋巴转移组的阳性率较无淋巴转移组明显升高（P<0.01）。RECK及MMP-9在宫颈鳞癌中的表达呈负相关关系（P<0.01）。结论：RECK在宫颈鳞癌中表达减少或缺失可能是通过上调MMP-9的表达从而促进宫颈鳞癌的侵袭与转移,RECK和MMP-9与宫颈鳞癌的浸润转移密切相关。

English Abstract

Expression and significance of RECK and MMP-9 in cervical squamous cell carcinoma

1. Department of Gynecology and Obstetrics, The First People's Hospital of Bengbu, Bengbu Anhui 233000;
2. Department of Gynecological Tumor, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Received Date: 2015-10-31

Abstract: Objective: To investigate the expressions and significance of RECK and matrixmetalloproteinase-9(MMP-9) in the cervical squamous cell carcinoma.Methods: The expressions of RECK and MMP-9 in 20 cases of normal cervical tissue and 70 cases of cervical squamous cell carcinoma were detected using immune histochemical staining method.Results: The positive rates of RECK protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 95.00% and 31.43%,respectively,the difference of which was statistically significant(P<0.01).Compared with the cervical squamous cell carcinoma patients without lymph node metastasis,the positive rate of RECK in patients with lymph node metastasis significantly decreased(P<0.01).The positive rates of MMP-9 protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 25.00% and 80.00%,respectively,the difference of which was statistically significant(P<0.01).Compared with the cervical squamous cell carcinoma patients without lymph node metastasis,the positive rate of MMP-9 in patients with lymph node metastasis significantly increased(P<0.01).The expression of RECK in cervical squamous carcinoma was negative correlation with the expression of MMP-9(P<0.01).Conclusions: The decreasing or absent of the RECK expression in cervical squamous carcinoma maybe though upregulate the expression of MMP-9 to promote the infiltration and metastasis of cervical squamous carcinoma.The RECK and MMP-9 are closely related to the infiltration and metastasis.