心脏型脂肪酸结合蛋白在急性心肌梗死早期诊断中的应用

张效明; 张鹏; 焦贤春; 王廷涛; 张俊; 汪朝晖

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心脏型脂肪酸结合蛋白在急性心肌梗死早期诊断中的应用

张效明 , 张鹏 , 焦贤春 , 王廷涛 , 张俊 , 汪朝晖

文章导航 > 蚌埠医学院学报 > 2010, 35 > 6: (568-570)

引用本文:

Citation:

心脏型脂肪酸结合蛋白在急性心肌梗死早期诊断中的应用

1. 蚌埠医学院第二附属医院心血管内科, 安徽蚌埠 233040;
2. 蚌埠医学院第二附属医院核医学科, 安徽蚌埠 233040

作者简介: 张效明(1960-),男,副主任医师

基金项目:
蚌埠医学院科研基金资助项目(BY0732)
中图分类号: R542.22

Heart-type fatty acid binding protein in early diagnosis of acute myocardial infarction

1. Department of Cardiovascular, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China;
2. Department of Nuclear Medicine, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China
CLC number: R542.22

摘要: 目的:探讨心脏型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AM I)早期诊断中的价值。方法:将60例AM I患者按发病时间不同分为2组,分别在发病0~3 h、4~6 h内检测H-FABP、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)的含量,计算各项指标的灵敏度、特异度、阳性预测值及阴性预测值,并与正常对照组和冠心病心绞痛组进行比较分析。结果:0~3 h及4~6 h AM I组的血浆H-FABP浓度均明显高于正常对照组及冠心病心绞痛组(P<0.01),在发病0~3 h及4~6 h内H-FABP诊断AM I的阳性率分别为67.74%和89.66%均高于cTnI(29.03%、62.07%)和CK-MB(0.00%、58.62%)(P<0.01~P<0.05);0~3 h内H-FABP的阳性预测值及阴性预测值为91.30%和86.84%,CK-MB为0.00%和68.69%;在0~3 h及4~6 h内H-FABP诊断AM I的特异度均为97.06%,cTnI和CK-MB的特异度为98.53%和100.00%。结论:H-FABP较cTnI和CK-MB更具有早期诊断AM I的临床应用价值。
- 心肌梗死 /
- 心脏型脂肪酸结合蛋白 /
- 心肌肌钙蛋白I /
- 肌酸激酶同工酶 /
- 肌红蛋白
Abstract: Objective:To assess the value of heart-type fatty acid binding protein (H-FABP) in early diagnosis of acute myocardial infarction (AMI).Methods:Sixty cases of AMI patients were divided into 2 groups according to the time of receiving treatment.The H-FABP,cTnI and CK-MB were detected 0-3 hours and 4-6 hours after the onset.The sensitivity,specificity,positive predictive value and negative predictive value were calculated,and the results were analyzed and compared with those of the normal control and the angor pectoris group.Results:The level of plasma H-FABP concentration in the AMI patients receiving treatment 0-3 hours and 4-6 hours after onset was significantly higher than that of the the control group and the angor pectoris group (P<0.01);the sensitivity of H-FABP within 0-3 hours and 4-6 hours of onset was 67.74% and 89.66%,respectively in diagnosis of AMI,which was significantly higher than that of cTnI (29.03%,62.07%) and CK-MB (0.00%,58.62%) (P<0.01 and P<0.05);the positive predictive value and negative predictive value of H-FABP were 91.30% and 86.84%,CK-MB within 0-3 hours of onset were 0.00% and 68.69%.The specificity value of H-FABP within 0-3 hours and 4-6 hours of onset was 97.06%,which was similar to that of cTnI and CK-MB in diagnosis of AMI were 98.53% and 100.00%.Conclusions:H-FABP is superior to cTnI and CK-MB in diagnosis of AMI.
- myocardial infarction /
- heart-type fatty acid-binding protein /
- cardiac troponin I /
- creatine kinase isoenzyme MB /
- myoglobin

[1]	徐家丽 , 赵武 , 王亚明 . 新生儿缺氧缺血性脑病血清心肌肌钙蛋白I检测的诊断价值. 蚌埠医学院学报, 2005, 30(3): 233-234.
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心脏型脂肪酸结合蛋白在急性心肌梗死早期诊断中的应用

作者简介: 张效明(1960-),男,副主任医师

1. 蚌埠医学院第二附属医院心血管内科, 安徽蚌埠 233040;
2. 蚌埠医学院第二附属医院核医学科, 安徽蚌埠 233040

收稿日期: 2009-09-27

基金项目: 蚌埠医学院科研基金资助项目(BY0732)

关键词:

摘要: 目的:探讨心脏型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AM I)早期诊断中的价值。方法:将60例AM I患者按发病时间不同分为2组,分别在发病0~3 h、4~6 h内检测H-FABP、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)的含量,计算各项指标的灵敏度、特异度、阳性预测值及阴性预测值,并与正常对照组和冠心病心绞痛组进行比较分析。结果:0~3 h及4~6 h AM I组的血浆H-FABP浓度均明显高于正常对照组及冠心病心绞痛组(P<0.01),在发病0~3 h及4~6 h内H-FABP诊断AM I的阳性率分别为67.74%和89.66%均高于cTnI(29.03%、62.07%)和CK-MB(0.00%、58.62%)(P<0.01~P<0.05);0~3 h内H-FABP的阳性预测值及阴性预测值为91.30%和86.84%,CK-MB为0.00%和68.69%;在0~3 h及4~6 h内H-FABP诊断AM I的特异度均为97.06%,cTnI和CK-MB的特异度为98.53%和100.00%。结论:H-FABP较cTnI和CK-MB更具有早期诊断AM I的临床应用价值。

English Abstract

Heart-type fatty acid binding protein in early diagnosis of acute myocardial infarction

1. Department of Cardiovascular, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China;
2. Department of Nuclear Medicine, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040, China

Received Date: 2009-09-27

Abstract: Objective:To assess the value of heart-type fatty acid binding protein (H-FABP) in early diagnosis of acute myocardial infarction (AMI).Methods:Sixty cases of AMI patients were divided into 2 groups according to the time of receiving treatment.The H-FABP,cTnI and CK-MB were detected 0-3 hours and 4-6 hours after the onset.The sensitivity,specificity,positive predictive value and negative predictive value were calculated,and the results were analyzed and compared with those of the normal control and the angor pectoris group.Results:The level of plasma H-FABP concentration in the AMI patients receiving treatment 0-3 hours and 4-6 hours after onset was significantly higher than that of the the control group and the angor pectoris group (P<0.01);the sensitivity of H-FABP within 0-3 hours and 4-6 hours of onset was 67.74% and 89.66%,respectively in diagnosis of AMI,which was significantly higher than that of cTnI (29.03%,62.07%) and CK-MB (0.00%,58.62%) (P<0.01 and P<0.05);the positive predictive value and negative predictive value of H-FABP were 91.30% and 86.84%,CK-MB within 0-3 hours of onset were 0.00% and 68.69%.The specificity value of H-FABP within 0-3 hours and 4-6 hours of onset was 97.06%,which was similar to that of cTnI and CK-MB in diagnosis of AMI were 98.53% and 100.00%.Conclusions:H-FABP is superior to cTnI and CK-MB in diagnosis of AMI.