右美托咪定减轻肾上腺素-利多卡因引起低血压100例

孙燕; 谢先丰; 王棣馨; 郑思媛; 曹慧灵; 谢科宇

doi:10.13898/j.cnki.issn.1000-2200.2015.01.017

右美托咪定减轻肾上腺素-利多卡因引起低血压100例

四川省成都市第二人民医院麻醉科, 610017

作者简介: 孙燕(1982-),女,硕士,主治医师.

中图分类号: R651.1

Effect of dexmedetomidine in attenuating the hypotension induced by epinephrine-lidocaine:a report of 100 cases

Department of Anesthesiology, Chengdu Second People's Hospital, Chengdu Sichuan 610017, China
CLC number: R651.1

摘要: 目的:探讨右美托咪定(DEX)对全麻开颅患者头皮浸润注射肾上腺素-利多卡因混合液引起血流动力学改变的影响.方法:将100例颅内肿瘤患者随机均分成5组,头皮切口处浸润注射不同浓度的肾上腺素-利多卡因混合液16 ml,A组2.5 μg/ml,B组5 μg/ml,C组7.5 μg/ml,D组10 μg/ml;E组头皮浸润注射7.5 mg/ml前静脉泵注DEX1 μg/kg.记录诱导前(T_基础值)、浸润注射前或DEX使用前(T₀)和浸润注射后5 min内(T₁～T₁₀)血流动力学变化.结果:C组平均动脉压(MAP)下降程度>20%的患者多于D组(P<0.05).5组患者T_基础值和T₀ MAP、收缩压(SBP)差异均无统计学意义(P>0.05).A、B、C、D组各指标同一时点差异均无统计学意义(P>0.05).E组T₁、T₂、T₇～T₁₀ SBP均比T₀高(P<0.05～P<0.01),与C组比较,E组在T₁～T₅、T₈～T₉ SBP、T₁和T₃～T₁₀舒张压、T₁～T₁₀ MAP差异均有统计学意义(P<0.05～P<0.01),E组舒张压、MAP和心率不同时点差异均无统计学意义(P>0.05).结论:头皮浸润注射肾上腺素-利多卡因混合液可降低开颅患者的血压;静脉泵注DEX能减轻开颅患者头皮浸润注射肾上腺素-利多卡因混合液引起的低血压.
- 颅骨切开术 /
- 右美托咪定 /
- 肾上腺素-利多卡因 /
- 低血压
Abstract: Objective:To evaluate the effect of dexmedetomidine(DEX) on the hemodynamic changes induced by scalp infiltration with epinephrine-lidocaine mixture during craniotomy under general anesthesia.Methods:One hundred patients with intracranial tumor were randomly and equally divided into five groups, and each group was infiltrated 16 ml of epinephrine-lidocaine mixture of different concentrations:group A 2.5 μg/ml, group B 5 μg/ml, group C 7.5 μg/ml, group D 10 μg/ml and group E 7.5 mg/ml received intravenous pumping of DEX 1 μg/kg before scalp infiltration.The hemodynamic changes were recorded before anesthetic induction, infiltration, using DEX and 5 min after infiltration.Results:The number of the patients with declined mean arterial pressure(MAP) over 20% was greater in group C than that in group D(P<0.05).The MAP and systolic blood pressure(SBP) had no statistically significant difference among the five groups in T_{base values} and T₀(P>0.05).The SBP in group E on T₁, T₂, and T₇～T₁₀ was higher than that on T₀(P<0.05 to P<0.01);and compared with group C, the SBP on T₁～T₅, T₈～T₉, the diastolic blood pressure(DBP) on T₁ and T₃～T₁₀, and the MAP on T₁～T₁₀ had significant differences(P<0.05);the DBP, MAP and heart rate of group E had no significant differences at different time-points(P>0.05).Conclusions:The epinephrine-lidocaine mixture used for scalp infiltration could reduce the arterial pressure of the patients undergoing craniotomy;intravenous pumping of DEX could attenuate the hypotension degree induced by scalp infiltration of epinephrine-lidocaine mixture.
- craniotomy /
- dexmedetomidine /
- epinephrine-lidocaine /
- hypotension

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右美托咪定减轻肾上腺素-利多卡因引起低血压100例

作者简介: 孙燕(1982-),女,硕士,主治医师.

Effect of dexmedetomidine in attenuating the hypotension induced by epinephrine-lidocaine:a report of 100 cases

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右美托咪定减轻肾上腺素-利多卡因引起低血压100例

作者简介: 孙燕(1982-),女,硕士,主治医师.

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Effect of dexmedetomidine in attenuating the hypotension induced by epinephrine-lidocaine:a report of 100 cases

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右美托咪定减轻肾上腺素-利多卡因引起低血压100例

作者简介: 孙燕(1982-),女,硕士,主治医师.

Effect of dexmedetomidine in attenuating the hypotension induced by epinephrine-lidocaine:a report of 100 cases

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右美托咪定减轻肾上腺素-利多卡因引起低血压100例

作者简介: 孙燕(1982-),女,硕士,主治医师.

English Abstract

Effect of dexmedetomidine in attenuating the hypotension induced by epinephrine-lidocaine:a report of 100 cases

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