Wnt信号通路拮抗基因SFRP甲基化在大肠癌中的研究进展
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[1] Carcia M,JemalA,Ward EM,et al.Global cancer facts and ligures 2007[J].Atlanta,GA:American Cancer Society,2007. [2] Collavin L,Kirschner MW.The secreted Frizzled-related protein Sizzled functions a negative feedback regulator of extreme ventral mesoderm[J].Development,2003,130(4):805-816. [3] He TC,Sparks AB,Rago C,et al.Identification of c-myc as a target of the APC pathway[J].Science,1998,281(5382):1509-1512. [4] Shtutman M,Zhurinsky J,Simcha I,et al.The cyclinD1 gene is a target of the beta-catenin/LEF-1 pathway[J].Proc Ntal Acad Sci USA,1999,96(10):5522-5527. [5] Ramachandran I,Thavathiru E,Ramalingam S,et al.Wnt inhibitory factor1 induces a poptosis and inhibits cervical cancer growth,invasion and angiogenesis in vivo[J].Oncogene,2012,31(22):2725-2737. [6] Shiina H,Igawa M,Breault J,et al.The human T-cell factor-4 gene splicing isforms,Wnt signal pathway,and apoptosis in renal cell carcinoma[J].Clin Cancer Res,2003,9(6):2121-2132. [7] Marchenko ND,Marchenko GN,Weinreb RN,et al.Beta-catenin regulates the gene of MMP-26,a novel metalloproteinace expressed both in carcinomas and normal epithelial cells[J].Int J Biochem Cell Biol,2004,36(5):942-956. [8] 黄文斌.Wnt通路成员APC、β-Catenin、c-myc及黏附分子E-cadherin与大肠癌的关系[J].中国肿瘤临床与康复,2007,14(1):73-75. [9] Taipale J,Beaehy PA.The Hedgehog and WNT signaling pathways in cancer[J].Nature,2001,411(6835):349-354. [10] Krieghoff E,Behrens J,Mayr B.Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention[J].J Cell Sci,2006,119(7):1453-1463. [11] Okegewa T,Pong RC,Li Y,et al.The role of cell adhesion molecule in cancer progression and its application in cancer therapy[J].Acta Biochimica Polonica,2004,51(2):445-457. [12] Kawano Y,Kypta R.Secreted antagonists of the Wnt signaling pathway[J].J Cell Sci,2003,116(Pt 13):2627-2634. [13] Enomoto-Iwamoto M,Kitagaki J,Koyama E,et al.The wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis[J].Dev Biol,2002,251(1):142-156. [14] Baylin SB,Ohm JE.Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction[J].Nat Rev Cancer,2006,6(2):107-116. [15] Caldwell GM,Jones C,Gensberg K,et al.The Wnt antagonist Sfrp1 in colorectal tumorigenesis[J].Cancer Res,2004,64(2):883-888. [16] Qi J,Zhu YQ,Luo J,et al.Hypermethylation and expression regulation of secreted frizzled-related protein gene in colorectal tumor[J].World J Gastroenterol,2006,12(44):7113-7117 [17] 孙蕾娜,辛芝,潘毅,等,SFRP1基因表达与大肠肿瘤发生的关系研究[J].中国肿瘤临床,2008,35(6):323-326. [18] Wehrli M,Dougan ST,Caldwell KZ,et al.Arrow encodes an LDL-receptor-related protein essential for Wingless signaling[J].Nature,2000,407(6803):527-530. [19] Bienz M,Clevers H.Linking colorectal cancer to Wnt signaling[J].Cell,2000,103(2):311-320. [20] Htilsken J,Behrens J.The Wnt signaling pathway[J].J Cell Sci,2002,115(21):3977-3978. [21] Peifer M,Polakis R.W signaling in oncogenesis and embryogenesis,--a look outside the nucleus[J].Science,2000,287(5458):1606-1609. [22] Suzuki H,Watkins DN,Jair KW,et al.Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cance[J].Nat Genet,2004,36(4):417-422. [23] Nojima M,Suzuki H,Toyota M,et al.Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer[J].Oncogene,2007,26(32):4699-4713. [24] 齐健,朱尤庆,罗峻,等.结直肠肿瘤中SFRP基因的甲基化及表达调控[J].中华肿瘤杂志,2007,29(11):842-845. [25] Takagi H,Sasaki S,Suzuki H,et al.Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma[J].J Gastroenterol,2008,43(5):378-389. [26] He B,Lee AY,Dadfarmay S,et al.Secreted frizzled-related protein 4 is silenced by hyper-methylation and induces apoptosis inβ-catenin-deficient human meso-thelima cells[J].Cancer Res,2005,65(3):743-748. [27] Hendriks B,Reichmann E.Wnt signaling:a complex issue[J].Bio Res,2002,35(2):277-286. [28] Suzuki H,Toyota M,Nojima M,et al.SFRP,a family of new colorectal tumor suppressor candidate genes[J].Nippon Rinsho,2005,63(4):707-719. [29] Caldwell GM,Jones CE,Taniere P,et al.The Wnt antagonist SFRP1 is downregulated in Premalignant large bowel adenomas[J].Br J Cancer,2006,94(6):922-927. [30] Suzuki H,Gabrieflson E,Chen W,et al.A genomia screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer[J].Nat Genet,2002,31(2):141-149. [31] Muller HM,Oberwalder M,Fiegl H,et al.Methylation changes in faecal DNA:a marker for colorectal cancer screening[J].Lancet,2004,363(9417):1283-1285. [32] Oberwalder M,Zitt M,Wontner C,et al.SFRP2 methylation in fecal DNA-a marker for colorectal polyps[J].Int J Colorectal Dis,2008,23(1):15-19. [33] Zhang W,Bauer M,Croner RS,et al.DNA stool test for colorectal cancer.hypermethylation of the secreted frizzled-related protein-1 gene[J].Dis Colon Rectum,2007,50(10):1618-1626. [34] Huang D,Yu B,Deng Y,et al.SFRP4 was overexpressed in colorectal carcinoma[J].J Cancer Res Clin Oncol,2010,136(3):395-401.
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