丙戊酸镁防治偏头痛的疗效观察

许文芳; 陈育华; 谢静; 王春; 刘晓林

doi:10.13898/j.cnki.issn.1000-2200.2016.01.013

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

丙戊酸镁防治偏头痛的疗效观察

许文芳 , 陈育华 , 谢静 , 王春 , 刘晓林

文章导航 > 蚌埠医学院学报 > 2016, 41 > 1: (46-48)

引用本文:

Citation:

丙戊酸镁防治偏头痛的疗效观察

蚌埠医学院第一附属医院神经内科, 安徽蚌埠 233004

作者简介: 许文芳(1980-),女,主治医师.

中图分类号: R747.2

Effect of magnesium valprote in the treatment of migraine

Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China
CLC number: R747.2

摘要: 目的:探讨丙戊酸镁治疗偏头痛的有效性及安全性。方法:81例偏头痛患者,其中因失访脱落6例,按照就诊顺序编号,奇数者为氟桂利嗪组(37例,给予氟桂利嗪治疗),偶数者为丙戊酸镁组(38例,给予丙戊酸镁缓释片治疗)。观察2组患者治疗前及治疗3个月后的头痛发作频率及头痛严重程度。结果:治疗后氟桂利嗪组和丙戊酸镁组头痛发作频率均较治疗前明显降低(P<0.01),但2组差异无统计学意义(P>0.05);治疗后氟桂利嗪组和丙戊酸镁组头痛严重程度评分均较治疗前显著降低(P<0.01),且2组差异有统计学意义(P<0.05)。2组患者药物的不良反应率分别为18.92%和23.68%,差异无统计学意义(P>0.05)。结论:丙戊酸镁用于防治偏头痛安全有效。
- 偏头痛 /
- 丙戊酸镁 /
- 氟桂利嗪
Abstract: Objective:To explore the effects and safety of magnesium valproate in the treatment of migraine.Methods:Eighty-one patients with migraine(including miss follow-up 6 cases) were randomly divided into the flunarizine group(37 cases treated with flunarizine) and magnesium valprote group(38 cases treated with magnesium).Compared with before treatment, the frequency of headache attack and severity of headache in two groups after 3 months of treatment were analyzed.Results:Compared with before treatment, the frequency of headache attack in two groups decreased significantly(P<0.01), and the difference of which between two groups was not statistically significant after treatment(P>0.05).Compared with before treatment, the scores of headache severity in two groups decreased significantly(P<0.01), and the difference of which between two groups was statistically significant after treatment(P>0.05).The incidences of adverse reactions in flunarizine group and magnesium valprote group were 18.92% and 23.68%, respectively, the difference of which was not statistically significant(P>0.05).Conclusions:Magnesium valproate treating migraine is secure and effective.
- migraine /
- magnesium valproate /
- flunarizine

[1]	ZAMEEL CADER M. The molecular pathogenesis of migraine:new developments and opportunities[J]. Hum Mol Genet,2013, 22(R1):R39.
[2]	李舜伟,李焰生,刘若卓,等. 中国偏头痛诊断冶疔指南[J]. 中国疼痛医学杂志,2011,17(2):65.
[3]	ABU-ARAFEH I. Flunarizine for the prevention of migraine-a new look at an old drug[J]. Dev Med Child Neurol,2012,54(3):204.
[4]	SHAHIEN R,SALEH SA,BOWIRRAT A. Intravenous sodium valproate aborts migraine headaches rapidly[J]. Acta Neurol Scand,2011,123(4):257.
[5]	ALI Ⅱ,HERIAL NA,ORRIS M,et al. Migraine prophylaxis with topiramate and bone health in women[J]. Headache,2011,51(4):613.
[6]	LINDE M,MULLENERS WM,CHRONICLE EP,et al. Valproate(valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults[J]. Cochrane Database Syst Rev,2013,6(6):CD 010611.
[7]	MAUSKOP A,VARUGHESE J. Why all migraine patients should be treated with magnesium[J]. J Neural Transm,2012,119(5):575.
[8]	SILBERSTEIN SD,WINNER PK,CHMIEL JJ. Migraine preventive medication reduces resourceutiliz ation[J]. Headache,2003, 43(3):171.
[9]	GRACIA-NAYA M, RíOS C, GARCía-GOMARA MJ, et al. A comparative study of the effectiveness of topiramate and flunarizine in independent series of chronic migraine patients without medication abuse[J]. Rev Neurol,2013,57(8):347.
[10]	BOSTANI A,RAJABI A,MORADIAN N,et al. The effects of cinnarizine versus sodium valproate in migraine prophylaxis[J]. Int J Neurosci,2013,123(7):487.
[11]	TAJMIRRIAHI M,SOHELIPOUR M,BASIRI K,et al. The effects of sodium valproate with fish oil supplementation or alone in migraine prevention:a randomized single-blind clinical trial[J]. Iran J Neurol,2012,11(1):21.
[12]	RAPOPORT AM,BIGAL ME. Preventive migraine therapy:what is new[J]. Neurol Sci,2004,25(3):s177.
[13]	MULL ENERS WM,CH RONICLE EP,VREDEVELD JW,et al. Visual cortex excitability in migraine before and after valproat eprophylax is:a pilot study using TMS[J]. Eur J Neurol,2002,9(1):35.
[14]	GONULLU H,GONULLU E,KARADAS S,et al. The levels of trace elements and heavy metals in patients with acute migraine headache[J]. J Pak Med Assoc,2015,65(7):694.

[1]	刘彬 , 汪国胜 , 钟平 , 年夫顺 , 张尊胜 . 偏头痛患者MRI亚临床病变的特点. 蚌埠医学院学报, 2015, 40(11): 1500-1502. doi: 10.13898/j.cnki.issn.1000-2200.2015.11.012
[2]	汪国胜 , 刘彬 , 钟平 , 张雷 , 马争飞 . 成人偏头痛患者脑干听觉诱发电位的变化及机制. 蚌埠医学院学报, 2013, 37(12): 1563-1565.
[3]	高斌 . 天麻素治疗无先兆偏头痛患者57例疗效观察. 蚌埠医学院学报, 2014, 39(11): 1552-1553.
[4]	王连明 , 郭艳梅 . 偏头痛病人认知能力改变及与抑郁、焦虑的相关性研究. 蚌埠医学院学报, 2022, 47(2): 173-175. doi: 10.13898/j.cnki.issn.1000-2200.2022.02.008
[5]	夏明武 , 黄永铸 , 胡光民 , 秦勇 , 许浩 . 奥卡西平治疗偏头痛66例疗效观察. 蚌埠医学院学报, 2011, 36(7): 704-706.
[6]	刘晓丰 , 毕素芝 , 王长松 , 王芬 , 南晓芳 , 谢建军 . 儿童偏头痛与肥胖的相关性研究. 蚌埠医学院学报, 2017, 42(8): 1067-1070. doi: 10.13898/j.cnki.issn.1000-2200.2017.08.017
[7]	何刚 , 陈曦 . 经颅多普勒超声在女中学生月经期偏头痛血流状态的检测价值. 蚌埠医学院学报, 2009, 34(5): 431-432.
[8]	宗宝玉 , 陈铁光 . 利培酮口服液合并丙戊酸钠缓释片治疗老年躁狂症疗效观察. 蚌埠医学院学报, 2012, 36(7): 848-849,862.
[9]	方璟 , 赵亚洲 , 简维 , 陈维钧 . 丙戊酸钠注射液治疗癫痫持续状态12例. 蚌埠医学院学报, 2011, 36(5): 497-499.
[10]	陈仁军 , 胡春涛 , 袁力勇 , 刘功俭 . 静脉预注硫酸镁抑制丙泊酚注射痛的临床研究. 蚌埠医学院学报, 2012, 36(1): 29-32.
[11]	辛毅 . 多潘立酮、铝碳酸镁联用氟哌噻吨治疗慢性胃炎疗效观察. 蚌埠医学院学报, 2009, 34(2): 127-129.
[12]	杨武 , 喻永龙 , 王新帅 , 朱西平 , 张振华 . 钙镁合剂和甲钴胺预防奥沙利铂所致神经毒性疗效比较. 蚌埠医学院学报, 2013, 37(1): 37-40.
[13]	邢小芬 , 韩云志 , 尹红亚 , 刘会雪 , 童重新 . 盐酸利托君与硫酸镁联合治疗早产胎膜早破的临床疗效分析. 蚌埠医学院学报, 2018, 43(12): 1603-1605,1609. doi: 10.13898/j.cnki.issn.1000-2200.2018.12.018
[14]	余清 . 丙泊酚与七氟烷麻醉对骨科老年手术患者术后认知功能的影响. 蚌埠医学院学报, 2013, 37(8): 982-984.
[15]	李晓红 , 刘军 , 凌云志 . 七氟烷联合丙泊酚用于小儿微创心脏手术的麻醉效果观察. 蚌埠医学院学报, 2009, 34(12): 1070-1072.
[16]	邓宏平 , 黄丽 , 徐志云 , 石伯生 . 丙泊酚和异氟烷联合麻醉在悬雍垂咽腭弓成形术中的应用. 蚌埠医学院学报, 2007, 32(4): 469-470.
[17]	陈龙 , 张茂银 , 耿兴云 . 丙泊酚靶控复合吸入低浓度异氟烷在小儿短小手术中的应用. 蚌埠医学院学报, 2007, 32(6): 720-722.
[18]	廖骏华 , 杨华英 , 张良 . 左西替利嗪联合孟鲁司特治疗儿童慢性特发性荨麻疹的疗效观察. 蚌埠医学院学报, 2017, 42(9): 1223-1226. doi: 10.13898/j.cnki.issn.1000-2200.2017.09.021
[19]	关勇 . 利培酮口服液联合长效氟哌啶醇注射液治疗女性慢性精神分裂症42例疗效分析. 蚌埠医学院学报, 2013, 37(10): 1345-1347.
[20]	刘绪和 , 梁冰 . 氟哌噻吨美利曲辛治疗老年糖尿病性胃肠功能紊乱伴焦虑抑郁病人的效果观察. 蚌埠医学院学报, 2019, 44(4): 449-451. doi: 10.13898/j.cnki.issn.1000-2200.2019.04.008

点击查看大图

计量

文章访问数: 2852
HTML全文浏览量: 552
PDF下载量: 122
被引次数: 0

丙戊酸镁防治偏头痛的疗效观察

作者简介: 许文芳(1980-),女,主治医师.

蚌埠医学院第一附属医院神经内科, 安徽蚌埠 233004

收稿日期: 2014-02-18

关键词:

摘要: 目的:探讨丙戊酸镁治疗偏头痛的有效性及安全性。方法:81例偏头痛患者,其中因失访脱落6例,按照就诊顺序编号,奇数者为氟桂利嗪组(37例,给予氟桂利嗪治疗),偶数者为丙戊酸镁组(38例,给予丙戊酸镁缓释片治疗)。观察2组患者治疗前及治疗3个月后的头痛发作频率及头痛严重程度。结果:治疗后氟桂利嗪组和丙戊酸镁组头痛发作频率均较治疗前明显降低(P<0.01),但2组差异无统计学意义(P>0.05);治疗后氟桂利嗪组和丙戊酸镁组头痛严重程度评分均较治疗前显著降低(P<0.01),且2组差异有统计学意义(P<0.05)。2组患者药物的不良反应率分别为18.92%和23.68%,差异无统计学意义(P>0.05)。结论:丙戊酸镁用于防治偏头痛安全有效。