内吗啡肽对心血管系统作用的研究进展

宗巧凤; 李正红

doi:10.13898/j.cnki.issn.1000-2200.2016.01.043

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

内吗啡肽对心血管系统作用的研究进展

宗巧凤 , 李正红

文章导航 > 蚌埠医学院学报 > 2016, 41 > 1: (132-134)

引用本文:

Citation:

内吗啡肽对心血管系统作用的研究进展

蚌埠医学院生理学教研室, 安徽蚌埠 233030

作者简介: 宗巧凤(1987-),女,硕士研究生.

基金项目:
安徽省自然科学基金项目(1508085MH170)

蚌埠医学院研究生创新计划项目(Byycx1307)
中图分类号: R961;R331

- 内吗啡肽 /
- 心血管系统 /
- 阿片受体 /
- 综述

[1]	ZADINA JE,HACKLER L,GE LJ,et al. A potent and selective endogenous agonist for the mu-opiate receptor[J]. Nature,1997, 386(6624):499.
[2]	DE MARCO R,JANECKA A. Strategies to improve bioavailability and in vivo efficacy of the endogenous opioid peptides endomorphin-1 and endomorphin-2[J]. Curr Top Med Chem, 2015,16(2):141.
[3]	PERLIKOWSKA R,JANECKA A. Bioavailability of endomorphins and the blood-brain barrier-a review[J]. Med Chem,2014,10(1):2.
[4]	COWELL SM,LEE YS,CAIN JP,et al. Explorng Ramachandran and chi space:conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands[J]. Curr Med Chem,2004,11(21):2785.
[5]	JANECKA A,STANISZEWSKA R,FICHNA J. Endomorphin analogs[J]. Curr Med Chem,2007,14(30):3201.
[6]	WANG CL, GUO C, ZHOU Y, et al. In vitro and in vivo characterization of opioid activities of C-terminal esterified endomorphin-2 analogs[J]. Peptides,2009,30(9):1697.
[7]	CHAMPION HC,ZADINA JE,KASTIN AJ,et al. Endomorphin 1 and 2 have vasodepressor activity in the anesthetized mouse[J]. Peptides,1998,19(5):925.
[8]	CHAMPION HC,ZADINA JE,KASTIN AJ,et al. The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit[J]. Biochem Biophys Res Commun,1997,235(3):567.
[9]	CHAMPION HC,ZADINA JE,KASTIN AJ,et al. Endomorphin 1 and 2,endogenous ligands for the mu-opioid receptor,decrease cardiac output, and total peripheral resistance in the rat[J]. Peptides,1997,18(9):1393.
[10]	WU N,HUO XF,CHEN Q,et al. Effects of intracerebroventricular administration of endomorphin-1 on blood pressure in anesthetized rats[J]. Yao Xue Xue Bao,2001,36(10):731.
[11]	LIU J, WU WM, CHE JJ, et al. Endomorphins restored the endothelium-dependent relaxation of the rabbit aorta rings exposed to high D-glucose condition via NO-cGMP pathway[J]. Protein Pept Lett,2006,13(10):1037.
[12]	WANG CL,YU Y,LAI LH,et al. Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats[J]. Peptides,2007,28(4):871.
[13]	PUGSLEY MK. The diverse molecular mechanisms responsible for the actions of opioids on the cardiovascular system[J]. Pharmacol Ther,2002,93(1):51.
[14]	KWOK EH,DUN NJ. Endomorphins decrease heart rate and blood pressure possibly by activating vagal afferents in anesthetized rats[J]. Brain Res,1998,803(1/2):204.
[15]	VIARD E,SAPRU HN. Endomorphin-2 in the medial NTS attenuates the responses to baroreflex activation[J]. Brain Res,2006(1073/1074):365.
[16]	白三省,陈文生,杨阳,等.μ阿片受体在大鼠腹主动脉、心脏和肾脏的分布和定位[J].中国体外循环杂志,2012,10(4):239.
[17]	CHAMPION HC,BIVALACQUA TJ,FRIEDMAN DE,et al. Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat[J]. Peptides,1998,19(9):1595.
[18]	QI YM,YANG DJ,DUAN X,et al. Endomorphins inhibit contractile responses of rat thoracic aorta rings induced by phenylephrine and angiotensin Ⅱ in vitro[J]. Acta Pharmacol Sin,2002,23(1):40.
[19]	CHEN ZC,SHIEH JP,CHUNG HH,et al. Activation of peripheral opioid μ-receptors in blood vessel may lower blood pressure in spontaneously hypertensive rats[J]. Pharmacology, 2011, 87(5/6):257.
[20]	DAI X, SONG HJ, CUI SG, et al. The stimulative effects of endogenous opioids on endothelial cell proliferation,migration and angiogenesis in vitro[J]. Eur J Pharmacol,2010,628(1/3):42.
[21]	LIU J,WEI S,TIAN L,et al. Effects of endomorphins on human umbilical vein endothelial cells under high glucose[J]. Peptides, 2011,32(1):86.
[22]	FENG Y,ZHAO QY,CHEN Q,et al. Vasorelaxant responses to endomorphin 1[psi] and endomorphin 2[psi], analogues of endomorphins,in rat aorta rings[J]. Pharmazie,2005,60(11):851.
[23]	ZHAO QY, CHEN Q, FENG Y, et al.[TIC4] endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings[J]. Protein Pept Lett,2005, 12(4):323.
[24]	YU Y, WANG CL, CUI Y, et al. C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats[J]. Peptides,2006,27(1):136.
[25]	LIU H,YANG Y,XIN R,et al. Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats[J]. Peptides,2008,29(6):1048.
[26]	TANAKA K, KERSTEN JR, RIESS ML. Opioid-induced cardioprotection[J]. Curr Pharm Des,2014,20(36):5696.
[27]	LI R, WONG GT, WONG TM, et al. Intrathecal morphine preconditioning induces cardioprotection via activation of delta, kappa,and mu opioid receptors in rats[J]. Anesth Analg,2009, 108(1):23.
[28]	MASLOV LN,NARYZHNAIA NV,TSIBULNIKOV SY,et al. Role of endogenous opioid peptides in the infarct size-limiting effect of adaptation to chronic continuous hypoxia[J]. Life Sci,2013,93(9/11):373.
[29]	宗巧凤,张冠军,于影,等.内吗啡肽-1后处理对大鼠心肌缺血再灌注损伤的作用[J].蚌埠医学院学报,2014,39(10):1317.
[30]	BROWN DA, SABBAH HN, SHAIKH SR. Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injury[J]. Pharmacol Ther,2013,140(3):258.
[31]	NERI M,FINESCHI V,DI PAOLO M,et al. Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction[J]. Curr Vasc Pharmacol,2015,13(1):26.
[32]	GONG P,CHEN FX,ZHAO Q,et al. The oxidation metabolites of endomorphin 1 and its fragments induced by free radicals[J]. J Pept Sci,2009,15(5):337.
[33]	FENG Y,LU Y,LIN X,et al. Endomorphins and morphine limit anoxia-reoxygenation-induced brain mitochondrial dysfunction in the mouse[J]. Life Sci,2008,82(13/14):752.

[1]	胡杰 , 汪思应 , 李正红 . 侧脑室注射内吗啡肽-1对大鼠心功能的影响. 蚌埠医学院学报, 2005, 30(5): 390-392.
[2]	胡杰 , 汪思应 . 静脉和侧脑室注射内吗啡肽-1对大鼠血清一氧化氮含量和一氧化氮合酶活性的影响. 蚌埠医学院学报, 2007, 32(4): 388-390.
[3]	高峰 . 食管癌研究现状综述. 蚌埠医学院学报, 2010, 35(6): 645-648.
[4]	朱晓雷 , 张恒 . 脂联素对心血管系统作用的研究现状. 蚌埠医学院学报, 2010, 35(4): 424-426.
[5]	谭慧玲 , 赵士弟 . TRPC3、TRPC6通道与心血管疾病的研究进展. 蚌埠医学院学报, 2021, 46(2): 273-277. doi: 10.13898/j.cnki.issn.1000-2200.2021.02.036
[6]	明希希 , 王涛 . 维生素D受体在系统性红斑狼疮中的免疫调节作用研究进展. 蚌埠医学院学报, 2023, 48(5): 698-701. doi: 10.13898/j.cnki.issn.1000-2200.2023.05.034
[7]	王安生 , 刘学刚 . 肺血减少型先天性心脏病远端肺血管发育不良的病理学研究现状. 蚌埠医学院学报, 2010, 35(4): 432-433.
[8]	王冉 , 张晓梅 . 人促甲状腺激素受体及其抗体与Graves病关系研究进展. 蚌埠医学院学报, 2013, 37(4): 505-509.
[9]	赵德生 , 佘强 . 脑钠肽和氨基末端脑钠肽前体在心力衰竭中的应用. 蚌埠医学院学报, 2008, 33(1): 121-123.
[10]	黄涛 , 李静 , 殷献录 . 嵌合抗原受体修饰T细胞在复发、难治性慢性淋巴细胞白血病中的治疗进展. 蚌埠医学院学报, 2017, 42(1): 139-141. doi: 10.13898/j.cnki.issn.1000-2200.2017.01.043
[11]	杨丽 , 张俊祥 . 胆道系统疾病影像学诊断方法及进展. 蚌埠医学院学报, 2011, 36(5): 535-539.
[12]	胡司淦 . Fas系统在冠心病和慢性心力衰竭中的变化及意义. 蚌埠医学院学报, 2006, 31(4): 439-440.
[13]	刘婷婷 . 整合子-基因盒系统在细菌耐药性中的作用. 蚌埠医学院学报, 2006, 31(2): 215-217.
[14]	冯艳 , 李志军 . 系统性红斑狼疮易感基因的研究进展. 蚌埠医学院学报, 2011, 36(11): 1284-1287.
[15]	高国全 . 血管抑制因子治疗血管增生性疾病的研究进展. 蚌埠医学院学报, 2008, 33(6): 694-698.
[16]	方娇 , 李志军 . CpG基序和TLR9与系统性红斑狼疮的研究进展. 蚌埠医学院学报, 2011, 36(9): 1036-1039.
[17]	吴维 , 余继海 , 胡何节 . 脂肪组织来源的基质细胞与血管新生. 蚌埠医学院学报, 2007, 32(3): 369-370.
[18]	孙京华 , 钟萍 . 血管性痴呆炎症细胞因子. 蚌埠医学院学报, 2012, 36(2): 228-230.
[19]	朱安凯 . 颅内生殖细胞瘤的诊断与治疗现状. 蚌埠医学院学报, 2006, 31(1): 106-108.
[20]	张舒龙 , 李仕青 . 腹腔内高压和腹腔室隔综合征的病理生理研究进展. 蚌埠医学院学报, 2009, 34(1): 85-87.