妊娠期亚临床甲状腺功能减退合并贫血对妊娠结局的影响

张红; 丁红梅

doi:10.13898/j.cnki.issn.1000-2200.2016.03.020

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

妊娠期亚临床甲状腺功能减退合并贫血对妊娠结局的影响

张红 , 丁红梅

文章导航 > 蚌埠医学院学报 > 2016, 41 > 3: (342-344)

引用本文:

Citation:

妊娠期亚临床甲状腺功能减退合并贫血对妊娠结局的影响

张红,
丁红梅

苏州大学附属第一医院妇产科, 苏州 215006

作者简介: 张红(1982-),女,硕士,主治医师.

中图分类号: R581.2

The effect of subclinical hypothyroidism complicated with anemia on pregnant outcome

Department of Obsterics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou Jiangsu 215006, China
CLC number: R581.2

摘要: 目的:探讨妊娠晚期亚临床甲状腺功能减退(甲减)合并贫血对产妇和新生儿的影响及其预防措施。方法:随机选取住院分娩的孕妇401例,根据甲状腺功能及血常规情况,分为单纯亚临床甲减组(Ⅰ组)161例,亚临床甲减合并贫血组(Ⅱ组)82例,正常孕妇对照组(Ⅲ组)158例。对比3组孕妇的产后出血率、剖宫产率、羊水过少发生率、羊水污染率、胎儿窘迫率、新生儿窒息率、小于孕龄儿出生率。结果:Ⅰ组和Ⅱ组孕妇剖宫产率及Ⅱ组羊水污染率、胎儿窘迫率均高于Ⅲ组(P<0.05)。3组孕妇其余各项指标差异无统计学意义(P>0.05)。结论:妊娠期亚临床甲减合并贫血增加了妊娠结局的不良影响,应加强妊娠期亚临床甲减患者贫血的防治。
- 甲状腺功能减退 /
- 妊娠 /
- 贫血 /
- 产后出血
Abstract: Objective:To investigate the effects of subclinical hypothyroidism complicated with anemia on puerpera and neonate, and its preventive measures.Methods:Four hundred and one pregnant women were divided into the subclinical hypothyroidism(161 cases, group Ⅰ), subclinical hypothyroidism complicated with anemia(82 cases, group Ⅱ), and normal puerpera(158 cases, group Ⅲ) according to the thyroid function and blood routine level.The incidences of postpartum hemorrhage, cesarean section, oligohydramnios, amniotic fluid contamination, fetal distress and neonatal asphyxia and small gestation age between three groups were compared.Results:The incidences of cesarean section in group Ⅰ and Ⅱ, and amniotic fluid pollution and fetal distress in group Ⅱ were higher than those in group Ⅲ(P<0.05).There were no statistical difference in other indexes between three groups(P>0.05).Conclusions:The subclinical hypothyroidism complicated anemia has adverse effects on pregnancy outcome, the prevention of which should be strengthened.
- hypothyroidism /
- pregnancy /
- anemia /
- postpartum hemorrhage

[1]	滕卫平.对血清促甲状腺激素正常值范围的新认识[J].中华内科杂志,2006,45(2):89.
[2]	ABALOVICH M,AMINO N,BARBOUR LA,et al.Management of thyroid dysfunction during pregnancy and postpartum:an endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2007,92(8):S1.
[3]	陈爱群,邱洁,方虹.妊娠前半期甲状腺功能变化的筛查及分析[J].中国妇幼健康研究,2010,21(5):598.
[4]	MANNISTO T,VAARASMAKI M,POUTA A,et al.Thyroid dysfunction and autoantibodies during pregnancy as predictive factors of pregnancy complications and maternal morbidity in later life[J].Clin Endocrinol Metab,2010,95(3):1084.
[5]	JULVEZ J,ALVAREZ-PEDREROL M,REBAGLIATO M,et al.Thyroxine levels during pregnancy in healthy women and early child neurodevelopment[J].Epidemiology,2013,24(1):150.
[6]	SU PY,HUANG K,HAO JH,et al.Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development:a prospective population-based cohort study in China[J].Clin Endocrinol Metab,2011,96(10):3234.
[7]	SAHU MT,DAS V,MITTAL S,et al.Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome[J].Arch Gynecol Obstet,2010,281(2):215.
[8]	SAHAY RK,NAGESH VS.Hypothyroidism in pregnancy[J].Indian J Endocrinol Metab,2012,16(3):364.
[9]	HADDOW JE,PALOMAKI GE,ALLAN WC,et al.Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child[J].N Engl J Med 1999,341(8):549.
[10]	HOLLOWELL JG,LAFRANCHI S,SMALLRIDGE RC,et al.2004 where do we go from here-Summary of working group discussions on thyroid function and gestational outcome[J].Thyroid,2005,15(1):72.
[11]	MCARDLE HJ,GAMBLING L,KENNEDY C.Iron deficiency during pregnancy:the consequences for placental function and fetal outcome[J].Proc Nutr Soc,2014,73(1):9.
[12]	RADLOWSKI EC,JOHNSON RW.Perinatial iron deficiency and neurocognitive development[J].Front Hum Neurosci,2013,23(7):585.
[13]	ALWAN NA,CADE JE,MCARDLE HJ,et al.Maternal iron status in early pregnancy and birth outcomes:insights from the Baby's Vascular health and Iron in Pregnancy study[J].Br J Nutr,2015,113(12):1985.
[14]	DE GROOT L,ABALOVICH M,ALEXANDER EK,et al.Management of thyroid dysfunction during pregnancy and postpartum:an Endocrine Society Clinical Practice Guideline[J].Clin Biochem Rev,2008,29(2):83.

[1]	陈静 , 赵冬 . 妊娠期亚临床甲状腺功能减退症左甲状腺素治疗剂量探讨. 蚌埠医学院学报, 2014, 39(10): 1340-1341,1344.
[2]	黄华 , 杨建碧 . 前列腺素类药物联合缩宫素预防高危妊娠剖宫产产后出血效果观察. 蚌埠医学院学报, 2019, 44(5): 597-599, 603. doi: 10.13898/j.cnki.issn.1000-2200.2019.05.009
[3]	蒋玉 . 甲状腺功能异常对妊娠结局的影响. 蚌埠医学院学报, 2014, 39(8): 1117-1119.
[4]	郑燕 . 兔妊娠后期注射甲状腺素影响仔兔生长的相关性分析. 蚌埠医学院学报, 2013, 37(7): 789-791.
[5]	马红星 . 孕期体质量指数干预对妊娠期糖尿病病人的影响. 蚌埠医学院学报, 2020, 45(7): 988-990. doi: 10.13898/j.cnki.issn.1000-2020.07.039
[6]	申震 , 赵卫东 , 吴大保 , 张秀英 . SLE患者妊娠期并发多脏器功能障碍综合征7例临床分析. 蚌埠医学院学报, 2006, 31(1): 44-45.
[7]	沈禾 , 张艳 . 妊娠合并心脏病患者不同心功能状态对母亲和围生儿的影响. 蚌埠医学院学报, 2009, 34(1): 28-29.
[8]	曹传武 , 李莉 , 钱建新 , 武清 , 骆益宙 , 许青 , 王杰军 . 肺癌患者贫血相关因素分析. 蚌埠医学院学报, 2007, 32(1): 27-29.
[9]	宋俊 . 早产儿贫血影响因素分析. 蚌埠医学院学报, 2016, 41(9): 1155-1157. doi: 10.13898/j.cnki.issn.1000-2200.2016.09.012
[10]	王坤 . 钩虫病致贫血26例分析. 蚌埠医学院学报, 2014, 38(1): 85-86.
[11]	周荣生 , 曹振平 . 不同止血方法应用于难治性产后出血的效果分析. 蚌埠医学院学报, 2019, 44(7): 880-884. doi: 10.13898/j.cnki.issn.1000-2200.2019.07.010
[12]	高怡平 , 水杰 , 张晓燕 . 孕妇自然分娩产后出血的风险列线图预测模型构建与验证. 蚌埠医学院学报, 2024, 49(2): 234-238. doi: 10.13898/j.cnki.issn.1000-2200.2024.02.021
[13]	马胜银 , 郝丽 , 刘朝阳 , 刘莉华 . 左旋肉碱对尿毒症血液透析患者贫血的改善作用. 蚌埠医学院学报, 2007, 32(1): 73-74.
[14]	王素侠 . 淮北地区6个月至6岁儿童缺铁性贫血调查. 蚌埠医学院学报, 2012, 36(10): 1237-1239.
[15]	邱珺 , 徐时平 . 急性冠状动脉综合征合并贫血的临床特征与院内结局的关系. 蚌埠医学院学报, 2017, 42(12): 1658-1660. doi: 10.13898/j.cnki.issn.1000-2200.2017.12.028
[16]	刘杰杰 , 范建灵 , 方晨 , 张云 , 张宁芝 . 宫腔球囊压迫、子宫动脉结扎和B-Lynch缝合在剖宫产难治性产后出血的应用. 蚌埠医学院学报, 2021, 46(8): 1069-1073. doi: 10.13898/j.cnki.issn.1000-2200.2021.08.020
[17]	田凌 , 吕晓蕊 , 阎艳彩 . 基于RhoA/Rho信号通路探讨产妇子宫平滑肌组织Thr38、KCa3.1、KLF4表达水平与产后出血的关系. 蚌埠医学院学报, 2023, 48(2): 186-190. doi: 10.13898/j.cnki.issn.1000-2200.2023.02.011
[18]	时红 , 胡灯元 . 剖宫产术中宫腔填塞预防产后出血22例分析. 蚌埠医学院学报, 2012, 36(11): 1325-1326.
[19]	曹旭 , 潘凤娟 , 王朝俊 . 子宫动脉结扎联合宫腔纱布填塞术治疗难治性产后大出血的效果观察. 蚌埠医学院学报, 2012, 36(8): 955-957.
[20]	薛丽芬 . 无锡市蠡湖社区7岁以下儿童5年体格检查结果分析. 蚌埠医学院学报, 2010, 35(12): 1300-1301.

点击查看大图

计量

文章访问数: 4233
HTML全文浏览量: 430
PDF下载量: 152
被引次数: 0

妊娠期亚临床甲状腺功能减退合并贫血对妊娠结局的影响

张红
丁红梅

作者简介: 张红(1982-),女,硕士,主治医师.

苏州大学附属第一医院妇产科, 苏州 215006

收稿日期: 2015-07-13

关键词:

摘要: 目的:探讨妊娠晚期亚临床甲状腺功能减退(甲减)合并贫血对产妇和新生儿的影响及其预防措施。方法:随机选取住院分娩的孕妇401例,根据甲状腺功能及血常规情况,分为单纯亚临床甲减组(Ⅰ组)161例,亚临床甲减合并贫血组(Ⅱ组)82例,正常孕妇对照组(Ⅲ组)158例。对比3组孕妇的产后出血率、剖宫产率、羊水过少发生率、羊水污染率、胎儿窘迫率、新生儿窒息率、小于孕龄儿出生率。结果:Ⅰ组和Ⅱ组孕妇剖宫产率及Ⅱ组羊水污染率、胎儿窘迫率均高于Ⅲ组(P<0.05)。3组孕妇其余各项指标差异无统计学意义(P>0.05)。结论:妊娠期亚临床甲减合并贫血增加了妊娠结局的不良影响,应加强妊娠期亚临床甲减患者贫血的防治。