冠心病患者Fractalkine、单核细胞趋化蛋白-1和白细胞介素-8的检测及意义

章春艳; 曹政; 杨勇; 詹艳

doi:10.13898/j.cnki.issn.1000-2200.2016.04.019

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冠心病患者Fractalkine、单核细胞趋化蛋白-1和白细胞介素-8的检测及意义

章春艳 , 曹政 , 杨勇 , 詹艳

文章导航 > 蚌埠医学院学报 > 2016, 41 > 4: (485-487)

引用本文:

Citation:

冠心病患者Fractalkine、单核细胞趋化蛋白-1和白细胞介素-8的检测及意义

湖北省十堰市太和医院心血管内科, 442000

作者简介: 章春艳(1976-),女,主管护师.

通讯作者: 曹政, 副主任医师.caozheng908@163.com ;

中图分类号: R541.4

The serum level change of Fractalkine,monocyte chemotactic protein-1 and interleukin-8 in patients with coronary heart disease and its significance

Department of Cardiology, Taihe Hospital of Shiyan, Shiyan Hubei 442000, China

Corresponding author: CAO Zheng, 副主任医师.caozheng908@163.com ;

CLC number: R541.4

摘要: 目的:探讨趋化因子Fractalkine、单核细胞趋化蛋白-1(MCP-1)和白细胞介素-8(IL-8)在不同类型冠心病(CHD)患者血清表达水平的变化及意义。方法:采集经冠状动脉造影确诊的稳定型心绞痛(SA)组患者48例、不稳定型心绞痛(UA)组患者56例、急性心肌梗死(AMI)组患者37例外周血标本,同期住院而冠状动脉造影正常的50例患者外周血标本作为对照组。采用酶联免疫吸附试验法检测4组血清Fractalkine、MCP-1和IL-8的表达水平,并以国际通用的Judkins法评估冠状动脉病变程度。结果:CHD患者血清Fractalkine、MCP-1和IL-8水平均明显高于对照组(P<0.01),UA和AMI组Fractalkine、MCP-1和IL-8水平均显著高于SA组(P<0.01);多支病变组和双支病变组Fractalkine、MCP-1和IL-8均明显高于单支病变组(P<0.01);重度狭窄组和中度狭窄组Fractalkine、MCP-1和IL-8水平亦显著高于轻度狭窄组(P<0.01)。结论:随着CHD患者病情的加重,血清趋化因子Fractalkine、MCP-1和IL-8水平明显升高,可用以评估CHD患者疾病的严重程度并监测疾病的进展情况。
- 冠心病 /
- Fractalkine /
- 单核细胞趋化蛋白-1 /
- 白细胞介素-8
Abstract: Objective: To explore the serum levels change of Fractalkine, monocyte chemotactic protein-1(MCP-1) and interleukin-8(IL-8) in patients with coronary heart disease(CHD) and its significance. Methods: After coronary angiography, 48 stable angina patients, 56 unstable angina patients, 37 acute myocardial infarction(AMI) patients and 50 healthy people were divided into the SA, UA, AMI and control group, respectively. The serum levels of Fractalkine, MCP-1 and IL-8 in four groups were measured using enzyme-linked immunosorbent assay, and the severity of coronary artery disease was evaluated by Judkins method. Results: The serum levels of Fractalkine, MCP-1 and IL-8 in CHD patients were significantly higher than those in control group(P<0.01), and the serum levels of Fractalkine, MCP-1 and IL-8 in UA and AMI group were significantly higher than those in SA group(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with double arteries and multiple arteries disease were significantly higher than those in patients with single artery disease(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with severe stenosis and moderate stenosis were significantly higher than those in patients with mild stenosis(P<0.01). Conclusions: The CHD patient illness aggravates with the serum levels of Fractalkine, MCP-1 and IL-8 increasing, which can evaluate the severity and development of disease in CHD patients.
- coronary heart disease /
- Fractalkine /
- monocyte chemotactic protein 1 /
- interleukin-8

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冠心病患者Fractalkine、单核细胞趋化蛋白-1和白细胞介素-8的检测及意义

通讯作者: 曹政, 副主任医师.caozheng908@163.com;

作者简介: 章春艳(1976-),女,主管护师.

湖北省十堰市太和医院心血管内科, 442000

收稿日期: 2015-04-19

关键词:

摘要: 目的:探讨趋化因子Fractalkine、单核细胞趋化蛋白-1(MCP-1)和白细胞介素-8(IL-8)在不同类型冠心病(CHD)患者血清表达水平的变化及意义。方法:采集经冠状动脉造影确诊的稳定型心绞痛(SA)组患者48例、不稳定型心绞痛(UA)组患者56例、急性心肌梗死(AMI)组患者37例外周血标本,同期住院而冠状动脉造影正常的50例患者外周血标本作为对照组。采用酶联免疫吸附试验法检测4组血清Fractalkine、MCP-1和IL-8的表达水平,并以国际通用的Judkins法评估冠状动脉病变程度。结果:CHD患者血清Fractalkine、MCP-1和IL-8水平均明显高于对照组(P<0.01),UA和AMI组Fractalkine、MCP-1和IL-8水平均显著高于SA组(P<0.01);多支病变组和双支病变组Fractalkine、MCP-1和IL-8均明显高于单支病变组(P<0.01);重度狭窄组和中度狭窄组Fractalkine、MCP-1和IL-8水平亦显著高于轻度狭窄组(P<0.01)。结论:随着CHD患者病情的加重,血清趋化因子Fractalkine、MCP-1和IL-8水平明显升高,可用以评估CHD患者疾病的严重程度并监测疾病的进展情况。

English Abstract

The serum level change of Fractalkine,monocyte chemotactic protein-1 and interleukin-8 in patients with coronary heart disease and its significance

Corresponding author: CAO Zheng, 副主任医师.caozheng908@163.com

Department of Cardiology, Taihe Hospital of Shiyan, Shiyan Hubei 442000, China

Received Date: 2015-04-19

Abstract: Objective: To explore the serum levels change of Fractalkine, monocyte chemotactic protein-1(MCP-1) and interleukin-8(IL-8) in patients with coronary heart disease(CHD) and its significance. Methods: After coronary angiography, 48 stable angina patients, 56 unstable angina patients, 37 acute myocardial infarction(AMI) patients and 50 healthy people were divided into the SA, UA, AMI and control group, respectively. The serum levels of Fractalkine, MCP-1 and IL-8 in four groups were measured using enzyme-linked immunosorbent assay, and the severity of coronary artery disease was evaluated by Judkins method. Results: The serum levels of Fractalkine, MCP-1 and IL-8 in CHD patients were significantly higher than those in control group(P<0.01), and the serum levels of Fractalkine, MCP-1 and IL-8 in UA and AMI group were significantly higher than those in SA group(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with double arteries and multiple arteries disease were significantly higher than those in patients with single artery disease(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with severe stenosis and moderate stenosis were significantly higher than those in patients with mild stenosis(P<0.01). Conclusions: The CHD patient illness aggravates with the serum levels of Fractalkine, MCP-1 and IL-8 increasing, which can evaluate the severity and development of disease in CHD patients.