急性胰腺炎合并糖尿病18例分析

郭兰; 燕善军; 王春

doi:10.13898/j.cnki.issn.1000-2200.2016.06.006

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急性胰腺炎合并糖尿病18例分析

郭兰 , 燕善军 , 王春

文章导航 > 蚌埠医学院学报 > 2016, 41 > 6: (725-727)

引用本文:

Citation:

急性胰腺炎合并糖尿病18例分析

1. 蚌埠医学院第二附属医院急诊消化病区, 安徽蚌埠 233040;
2. 蚌埠医学院第一附属医院消化内科, 安徽蚌埠 233004;
3. 蚌埠医学院第二附属医院内分泌科, 安徽蚌埠 233040

作者简介: 郭兰(1982-),女,主治医师.

通讯作者: 燕善军, 主任医师.e-mai:yansj2006@163.com ;

中图分类号: R576

Analysis of acute pancreatitis complicated with diabetes mellitus:a report of 18 cases

1. Department of Emergency Digestive Ward, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040;
2. Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China;
3.Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040

Corresponding author: YAN Shan-jun, 主任医师.e-mai:yansj2006@163.com ;

CLC number: R576

摘要: 目的：探讨急性胰腺炎（AP）合并糖尿病患者的临床特点，提高对此类患者诊断及治疗的认识。方法：回顾性分析58例AP患者的临床资料，其中轻症AP（MAP）41例，重症AP（SAP）17例；单纯AP（对照组）40例，AP合并糖尿病（观察组）18例，测定患者的随机血糖、空腹血糖、总胆固醇（TC）、三酰甘油（TG）、糖化血红蛋白（HbA1c）、血Ca²⁺浓度、C反应蛋白（CRP）等，对SAP患者进行急性生理与慢性健康（APACHEⅡ）评分，分析比较2组患者的生化指标及APACHEⅡ评分。结果：观察组患者随机血糖、空腹血糖、HbA1c、血Ca²⁺浓度、SAP的发生率和APECHEⅡ评分均明显高于对照组（P < 0.01）。结论：AP合并糖尿病患者的病情相对单纯AP患者更重，高血糖可能是早期AP病情加重的重要因素。
- 胰腺炎 /
- 糖尿病 /
- 急性生理与慢性健康评分 /
- 血Ca²⁺浓度
Abstract: Objective: To investigate the clinical characters of the patients with acute pancreatitis(AP) complicated with diabetes mellitus,and improve the understanding of the disease diagnosis and treatment.Methods: The clinical data of 41 patients with mild acute pancreatitis(MAP) and 17 patients with severe acute pancreatitis(SAP) were retrospectively analyzed.Forty patients with simple AP and 18 patients with AP complicated with diabetes were divided into the control group and observation group,respectively.The levels of triglyceride(TG),hemoglobin A1c(HbA1c),serum calcium and C-reactive protein(CRP) in all patients were measured,and the scores of Acute Physiology and Chronic Health Evaluation(APACHEⅡ) in SAP patients were evaluated.Biochemical Indexes,acute physiology and chronic health evaluation(APACHEⅡ) score between two groups were compared.Results: The levels of the blood-glucose,fasting blood-glucose,HbA1c and serum calcium,the incidence of SAP and the scores of APECHEⅡ in observation group were significantly higher than those in control group(P < 0.01).Conclusions: Compared with the simple AP patient,the disease condition in AP patients complicated with diabetes are more serious.The high level of serum glucose maybe an important aggravation factor in AP patients.
- pancreatitis /
- diabetes /
- acute physiology and chronic health evaluationⅡ /
- concentration of serum Ca²⁺

[1]	中华医学会消化病分会胰腺疾病学组.中国急性胰腺炎诊治指南(2013年,上海)[J].中华消化病杂志,2013,33(4):217.
[2]	徐惠明,许春芳.糖尿病并发急性胰腺炎40例临床分析[J].胃肠病学和肝病学科杂志,2011,20(11):1016.
[3]	CZAKÓL,HEQYI P,RAKONCZAY Z Jr,et al.Interactions between the endocrine and exocrine pancreas and their clinical relevance[J].Pancreatology,2009,9(4):351.
[4]	CHOI HJ,YUN HS,KANG HJ,et al.Transcriptome analysis of acute responses to glucose ingestion reveals the role of leukocytes in hyperglycemia-induced inflammation[J].Physiol Genomics,2012,44(24):1179.
[5]	张潇颖,林子琦,薛平,等.重症急性胰腺炎患者初期合并不同水平高血糖的临床研究[J].四川大学学报(医学版),2013,44(6):974.

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急性胰腺炎合并糖尿病18例分析

通讯作者: 燕善军, 主任医师.e-mai:yansj2006@163.com;

作者简介: 郭兰(1982-),女,主治医师.

1. 蚌埠医学院第二附属医院急诊消化病区, 安徽蚌埠 233040;
2. 蚌埠医学院第一附属医院消化内科, 安徽蚌埠 233004;
3. 蚌埠医学院第二附属医院内分泌科, 安徽蚌埠 233040

收稿日期: 2015-10-18

关键词:

摘要: 目的：探讨急性胰腺炎（AP）合并糖尿病患者的临床特点，提高对此类患者诊断及治疗的认识。方法：回顾性分析58例AP患者的临床资料，其中轻症AP（MAP）41例，重症AP（SAP）17例；单纯AP（对照组）40例，AP合并糖尿病（观察组）18例，测定患者的随机血糖、空腹血糖、总胆固醇（TC）、三酰甘油（TG）、糖化血红蛋白（HbA1c）、血Ca²⁺浓度、C反应蛋白（CRP）等，对SAP患者进行急性生理与慢性健康（APACHEⅡ）评分，分析比较2组患者的生化指标及APACHEⅡ评分。结果：观察组患者随机血糖、空腹血糖、HbA1c、血Ca²⁺浓度、SAP的发生率和APECHEⅡ评分均明显高于对照组（P < 0.01）。结论：AP合并糖尿病患者的病情相对单纯AP患者更重，高血糖可能是早期AP病情加重的重要因素。

English Abstract

Analysis of acute pancreatitis complicated with diabetes mellitus:a report of 18 cases

Corresponding author: YAN Shan-jun, 主任医师.e-mai:yansj2006@163.com

1. Department of Emergency Digestive Ward, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040;
2. Department of Gastroenterology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China;
3.Department of Endocrinology, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040

Received Date: 2015-10-18

Abstract: Objective: To investigate the clinical characters of the patients with acute pancreatitis(AP) complicated with diabetes mellitus,and improve the understanding of the disease diagnosis and treatment.Methods: The clinical data of 41 patients with mild acute pancreatitis(MAP) and 17 patients with severe acute pancreatitis(SAP) were retrospectively analyzed.Forty patients with simple AP and 18 patients with AP complicated with diabetes were divided into the control group and observation group,respectively.The levels of triglyceride(TG),hemoglobin A1c(HbA1c),serum calcium and C-reactive protein(CRP) in all patients were measured,and the scores of Acute Physiology and Chronic Health Evaluation(APACHEⅡ) in SAP patients were evaluated.Biochemical Indexes,acute physiology and chronic health evaluation(APACHEⅡ) score between two groups were compared.Results: The levels of the blood-glucose,fasting blood-glucose,HbA1c and serum calcium,the incidence of SAP and the scores of APECHEⅡ in observation group were significantly higher than those in control group(P < 0.01).Conclusions: Compared with the simple AP patient,the disease condition in AP patients complicated with diabetes are more serious.The high level of serum glucose maybe an important aggravation factor in AP patients.