帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

时鹏; 屈洪党; 李强; 陈育华; 李倩倩; 谢静

doi:10.13898/j.cnki.issn.1000-2200.2016.09.004

帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

蚌埠医学院第一附属医院神经内科, 安徽蚌埠 233004

作者简介: 时鹏(1981-),男,博士研究生.

基金项目:
安徽省教育厅自然科学一般项目（KJ2015B094by）
中图分类号: R742.5

The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China
CLC number: R742.5

摘要: 目的：检测帕金森病（PD）患者血清活化T细胞趋化因子（RANTES）水平及炎症因子白细胞介素（IL）-1β、IL-6、肿瘤坏死因子（TNF）-α的变化，探讨其在PD免疫异常发病机制中的作用。方法：采用ELISA法检测60例PD患者（PD组）和35名健康体检者（对照组）血清RANTES、IL-1β、IL-6、TNF-α水平，采用Hoehn-Yahr、UPDRS量表分别对PD患者进行病情评估，同时对2组年龄、性别、吸烟、饮酒、血糖、血压、血脂差异一般状况进行检查。结果：PD组患者血清RANTES、IL-1β、IL-6和TNF-α水平均显著高于对照组（P<0.01）；PD 1～5期患者血清RANTES水平差异均有统计学意义（P < 0.05～P < 0.01），而1～5期患者血清IL-1β、IL-6和TNF-α水平差异均无统计学意义（P>0.05）；PD患者UPDR评分组间血清RANTES水平轻、中和重度组差异均有统计学意义（P<0.01），而IL-1β、IL-6和TNF-α水平轻、中和重度各组间差异均无统计学意义（P>0.05）,且PD组血清RANTES水平与UPDRS评分呈显著正相关关系（P<0.01）。结论：PD患者血清RANTES、IL-1β、IL-6、TNF-α水平均较对照组有显著升高，提示炎症因子可能发动并维持了PD的发病进程，可为PD患者早期发现、防治提供优先依据。
- 帕金森病 /
- 活化T细胞趋化因子 /
- 白细胞介素-1β /
- 白细胞介素-6 /
- 肿瘤坏死因子-α
Abstract: Objective: To detect the levels of serum activated T cells chemokines(RANTES) and inflammatory cytokines[including interleukin(IL)-1β,IL-6 and tumor necrosis factor(TNF)-α] in Parkinson's disease(PD) patients,and explore its roles in abnormal immune pathogenesis of PD.Methods: The serum levels of RANTES,IL-1β,IL-6 and TNF-α in 60 PD patients(PD group) and 35 healthy people(control group) were examined using the ELISA method.The disease of PD patients was evaluated using the UPDRS and Hoehn-Yahr score.The age,sex,smoking,drinking alcohol,blood glucose,blood pressure and blood lipid in two groups were examined.Results: The serum levels of the RANTES,IL-1β,IL-6 and TNF-α in PD group were significantly higher than those in control group(P<0.01).The differences of the serum RANTES levels in stage 1 to 5 PD patients were statistically significant(P<0.05 to P<0.01),but for the differences of the serum levels of IL-1β,IL-6 and TNF-α were not statistically significant(P>0.05).The differences of the serum RANTES levels between the mild,moderate and severe PD patients identified by the UPDRS were statistically significant(P<0.01),but for the differences of the levels of IL-1β、IL-6 and TNF-α were not statistically significant(P>0.05),and the level of RANTES was significantly positive correlation with the UPDRS score(P<0.01).Conclusions: Compared with control group,the levels of RANTES,IL-1β,IL-6 and TNF-α in PD patients increase,which suggest that the inflammatory cytokines may initiate and sustain the process of pathogenesis of PD,and provide the reference in early finding and treating the PD.
- Parkinson's disease /
- activated T cells chemokines /
- interleukin-1β /
- interleukin-6 /
- tumor necrosis factor-α

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帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

作者简介: 时鹏(1981-),男,博士研究生.

The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

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帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

作者简介: 时鹏(1981-),男,博士研究生.

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The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

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帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

作者简介: 时鹏(1981-),男,博士研究生.

The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

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帕金森病患者血清活化T细胞趋化因子和炎症因子水平及其临床意义

作者简介: 时鹏(1981-),男,博士研究生.

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The serum levels of activated T cells chemokines RANTES and inflammatory cytokines in Parkinson's disease patients and its significance

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