血清胃蛋白酶原Ⅰ、Ⅱ在老年慢性胃炎患者筛查中的意义
Screening significance of the serum pepsinogen Ⅰ and Ⅱ in elderly patients with chronic gastritis
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摘要: 目的：探讨血清胃蛋白酶原（PG）Ⅰ、Ⅱ对老年慢性胃炎的筛查意义。方法：选择经胃镜和病理学检查诊断为慢性胃炎的患者98例，其中老年组（≥70岁）52例，中青年组（20～60岁）46例，分别对2组患者进行血清PGⅠ、PGⅡ检测，计算PGR（PGⅠ/PGⅡ）值。结果：2组中慢性萎缩性胃炎患者的PGⅠ水平和PGR均明显低于慢性非萎缩性胃炎患者（P<0.01）；老年组患者中慢性萎缩性胃炎患者的PGⅠ水平和PGR均显著低于中青年组（P<0.01）；老年组慢性萎缩性患者的ROC曲线图中，PGⅠ的临界值为98.06 μg/L，灵敏度和特异度分别为0.812和0.858；PGR的临界值为6.68，灵敏度和特异度分别为0.758和0.810。结论：检测血清PGⅠ、Ⅱ对于筛查老年慢性萎缩性胃炎患者具有重要意义，需要进一步确定其参考范围。Abstract: Objective: To explore the screening significance of serum pepsinogenⅠ and Ⅱ(PG Ⅰ and PG Ⅱ) in elderly patients with chronic gastritis.Methods: Ninety-eight elderly patients with chronic gastritis diagnosed by gastroscopy and pathology were divided into the elderly group(52 cases,over 70 years old) and young and middle-aged group(46 cases,20 to 60 years old).The serum levels of PG Ⅰ and PG Ⅱ in two groups were measured,and the value of PGR(PGⅠ/PGⅡ) was calculated.Results: The levels of the PGⅠand PGR in patients with chronic atrophic gastritis were significantly lower than those in patients with chronic non-atrophic gastritis in two groups(P<0.01).The levels of the PGⅠand PGR in the elderly group were significantly lower than those in young and middle-aged group(P<0.01).The ROC curve of the chronic atrophic patients in elderly group showed that the critical value of PG Ⅰ,sensitivity and specificity were 98.06 μg/L,0.812 and 0.858,respectively,and the critical value of PGR,sensitivity and specificity were 6.68 μg/L,0.758 and 0.810,respectively.Conclusions: The detection of serum pepsinogen Ⅰ and Ⅱ has important clinic significance in screening elderly patients with chronic atrophic gastritis,which need to further define its reference range.
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Key words:
- chronic gastritis /
- atrophy /
- pepsinogen /
- precancerous lesion
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