神经生长因子对脑出血病人神经功能缺损及骨桥蛋白表达的影响
Effect of the nerve growth factor on nerve dysfunction and osteopontin expression in patients with intracerebral hemorrhage
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摘要: 目的:观察神经生长因子(NGF)治疗脑出血的临床疗效,并探讨NGF对病人神经功能缺损、Barthel指数(BI)评分及骨桥蛋白(OPN)表达的影响。方法:将84例脑出血病人采用随机数字法分为观察组与对照组,各42例。对照组病人接受神经内科常规治疗并给予胞磷胆碱,观察组病人在常规治疗基础上予以NGF联合治疗,连续治疗2周。比较2组病人美国国立卫生研究院卒中量表(NIHSS)评分、BI评分、OPN水平以及临床治疗效果等指标。结果:治疗前,2组病人NIHSS评分、血清OPN水平、BI评分差异均无统计学意义(P>0.05),治疗后2组OPN水平及NIHSS评分均明显下降,且观察组OPN水平及NIHSS评分下降程度均明显高于对照组(P<0.01),而2组治疗后BI评分均明显增加,且观察组BI评分增高程度明显高于对照组(P<0.01);观察组的治疗总有效率(90.5%)高于对照组(71.4%)(P<0.05);观察组疗效优于对照组(P<0.05)。结论:采用NGF对脑出血病人进行治疗效果显著,能够有效改善病人的临床症状和神经功能缺损程度,降低血清OPN水平,促进病人恢复,安全性高,临床上值得继续推广。Abstract: Objective:To explore the clinical effects of the nerve growth factor(NGF) in the treatment of intracerebral hemorrhage,and effects of NGF on the nerve dysfunction,Barthel index(BI) score and osteopontin(OPN) expression.Methods:Eighty-four patients with intracerebral hemorrhage were randomly divided into the control group and observation group using random number method(42 cases each group).The control group was treated with conventional method combined with citicoline,and the observation group was additionally treated with NGF based on conventional method for 2 weeks.The National Institutes of Health Stroke Scale(NIHSS) and BI scores,OPN expression level and clinical efficiency between two groups were analyzed and compared after treatment.Results:The differences of the NIHSS and BI scores,and OPN expression level before treatment between two groups were not statistically significant(P>0.05).After treatment,the NIHSS score and OPN expression level in two groups significantly decreased,and the decreasing degree of those in observation group was significantly higher than that in control group(P<0.01).After treatment,the BI scores in two groups significantly increased,and the increasing degree of which in observation group was significantly higher than that in control group(P<0.01).The total effective rate of treatment in observation group(90.5%) was higher than that in control group(71.4%)(P<0.05).The curative effect in observation group was better than that in control group(P<0.05).Conclusions:The effect of NGF in the treatment of intracerebral hemorrhage is significant and safe,which can effectively improve the clinical symptoms and nerve dysfunction,reduce the OPN level,promote the recovery of patients,and is worthy of promotion.
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Key words:
- intracerebral hemorrhage /
- nerve growth factor /
- nerve dysfunction /
- osteopontin
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[1] 孟令秋,赵玉军,陈谦,等.神经生长因子治疗脑出血的临床疗效观察[J].中华老年心脑血管病杂志,2013,15(1):46. [2] 王红艳,姜涛,刘文文,等.注射用鼠神经生长因子治疗视神经挫伤的临床疗效观察[J].山东医药,2015,55(33):42. [3] JADHAO CS,BHATWADEKAR AD,JIANG Y,et al.Nerve growth factor promotes endothelial progenitor cell-mediated angiogenic responses[J].Invest Ophthalmol Visual Sci,2012,53(4):2030. [4] 李方,王璐,木塔里甫·买合木提,等.鼠神经生长因子对重症脑出血患者的疗效及对炎症因子、氧化应激的影响[J].海南医学院学报,2016,22(9):889. [5] 中华神经科学会.各类脑血管疾病的诊断要点和脑卒中患者神经功能评分标准[J].中华神经科杂志,1996,29(6):379. [6] DUNNING K.National Institutes of Health Stroke Scale[M]//Encyclopedia of Clinical Neuropsychology.New York:Springer,2011:1714. [7] LAZARIDIS I,CHARALAMPOPOULOS I,ALEXAKI VI,et al.Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors,preventing neuronal apoptosis.[J].Plos Biol,2011,9(4):141. [8] GONCHAROV NP,KATSIYA GV,DZHOKUA AA,et al.Effect of neurosteroiddehydroepiandrosterone on the higher nervous activity of old non-human primates[J].Human Physiol,2014,40(2):149. [9] 梁业飞.神经生长因子治疗急性脑出血的疗效及其对血清炎症因子的影响[J].广西医学,2015,37(9):1366. [10] 王东升,王红练,葛平,等.改良美国国立卫生院神经功能缺损量表评分床旁经颅彩色多普勒超声检查对缺血性卒中早期预后的评估价值[J].中国医师进修杂志,2014,37(22):35. [11] 李欣遥,张良荣,韩冬,等.脑出血患者血清骨桥蛋白水平的变化及其对预后的影响[J].临床神经病学杂志,2015,28(6):413. [12] 翟安林,袁淼,苟志勇,等.亚低温疗法辅助颅内血肿清除术治疗脑出血对患者血清炎性因子水平及其预后的影响[J].山东医药,2014,54(3):68. [13] EVRARD S,DELANAYE P,KAMEL S,et al.Vascular calcification:from pathophysiology to biomarkers[J].Clin Chim Acta,2015,438(1):401. [14] 郭宏伟,曾树林,杨金凤,等.注射用鼠神经生长因子联合头穴透刺治疗急性脑出血疗效分析[J].神经损伤与功能重建,2013,8(6):459. [15] 谭永星,王迪芬,李雪梅,等.神经生长因子预处理对沙土鼠全脑缺血/再灌注损伤脑神经细胞凋亡及Bcl-2和Bax蛋白表达的影响[J].中华危重急救医学,2007,19(6):358. [16] 项婕,潘小娟.鼠神经生长因子对急性脑出血患者肿瘤坏死因子-α、血清基质金属蛋白酶-9和超氧化物歧化酶水平的影响[J].实用药物与临床,2014,17(4):412.
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