陈兰花颗粒联合抗生素治疗对糖尿病足慢性创面细菌生物膜形成的作用

徐丽英; 钟萍; 曹烨民; 李土明; 王潇

doi:10.13898/j.cnki.issn.1000-2200.2017.09.007

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陈兰花颗粒联合抗生素治疗对糖尿病足慢性创面细菌生物膜形成的作用

徐丽英 , 钟萍 , 曹烨民 , 李土明 , 王潇

文章导航 > 蚌埠医学院学报 > 2017, 42 > 9: (1176-1179)

引用本文:

Citation:

陈兰花颗粒联合抗生素治疗对糖尿病足慢性创面细菌生物膜形成的作用

1. 上海中医药大学附属上海市中西医结合医院脉管科, 上海 200082;
2. 上海中医药大学附属上海市中西医结合医院脑病科, 上海 200082

作者简介: 徐丽英(1976-),女,主治医师.

通讯作者: 钟萍, 主任医师.zphgl@163.com ;

基金项目:
上海市虹口区卫生和计划生育委员会医学科研课题（虹卫1404-10）
中图分类号: R587.2

Clinical study of Chenlanhua granules combined with antibiotics in the treatment of bacterial biofilm of chronic wounds in diabetic foot

1. Department of Circulatory, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai 20082, China;
2. Department of Encephalopathy, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai 20082, China

Corresponding author: ZHONG Ping, 主任医师.zphgl@163.com ;

CLC number: R587.2

摘要: 目的：探讨陈兰花颗粒联合抗生素治疗对糖尿病足慢性创面的细菌生物膜形成的作用。方法：选取糖尿病足慢性创面病人71例，随机分为观察组和对照组，对照组36例在基础治疗上予外用0.9%氯化钠注射液治疗，观察组35例在基础治疗上予以外用陈兰花颗粒治疗，疗程为2周。观察2组治疗前后创面细菌检出率、菌落计数及血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）的变化。结果：治疗后观察组创面愈合总有效率明显高于对照组（P<0.01）。2组病人治疗前后创面组织病原致病菌差异均无统计学意义（P>0.05）。2组病人治疗后创面细菌菌落计数差值差异有统计学意义（P<0.01）。治疗后2组hs-CRP、IL-6、PCT均降低（P<0.05），且观察组下降更为显著（P<0.05~P<0.01）。结论：陈兰花颗粒外用治疗可抑制糖尿病足慢性创面细菌生物膜炎症因子表达，协同抗生素清除细菌生物膜，疗效显著。
- 糖尿病足 /
- 细菌生物膜 /
- 陈兰花颗粒
Abstract: Objective: To investigate the inhibiting effects of Chenlanhua granules combined with antibiotics on bacterial biofilm of chronic wounds in diabetic foot.Methods: Seventy-one patients with chronic wounds of diabetic feet were randomly divided into the observation group(35 cases) and control group(36 cases).The control group were treated with 0.9% sodium chloride injection by external use,and the observation group were additionally treated with Chenlanhua granules based on the control group for 2 weeks.The bacterial detection rate,colony count,and the levels of serum high sensitive C reactive protein(hs-CRP),interleukin-6(IL-6) and procalcitonin(PCT)in two groups were observed before and after treatment.Results: After treatment,the total healing rate of wounds in observation group was significantly higher than that in control group(P<0.01).The differences of the pathogenic bacteria of wounds between before and after treatment were not statistically significant in two groups(P>0.05).The difference of the D-value of colony count of wounds between two groups was statistically significant after treatment(P<0.01).The levels of hs-CRP,IL-6 and PCT in two groups significantly decreased(P<0.05),and the decreasing degrees of whose in observation group were more obvious(P<0.05 to P<0.01).Conclusions: The treatment of diabetic foot chronic wounds with Chen Lanhua granules can inhibit the expression of inflammatory factor and remove the bacterial biofilm in synergy with antibiotic,the curative effect of which is significant.
- diabetic foot /
- bacterial biofilm /
- Chenlanhua granule

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陈兰花颗粒联合抗生素治疗对糖尿病足慢性创面细菌生物膜形成的作用

通讯作者: 钟萍, 主任医师.zphgl@163.com;

作者简介: 徐丽英(1976-),女,主治医师.

1. 上海中医药大学附属上海市中西医结合医院脉管科, 上海 200082;
2. 上海中医药大学附属上海市中西医结合医院脑病科, 上海 200082

收稿日期: 2016-05-18

基金项目: 上海市虹口区卫生和计划生育委员会医学科研课题（虹卫1404-10）

关键词:

摘要: 目的：探讨陈兰花颗粒联合抗生素治疗对糖尿病足慢性创面的细菌生物膜形成的作用。方法：选取糖尿病足慢性创面病人71例，随机分为观察组和对照组，对照组36例在基础治疗上予外用0.9%氯化钠注射液治疗，观察组35例在基础治疗上予以外用陈兰花颗粒治疗，疗程为2周。观察2组治疗前后创面细菌检出率、菌落计数及血清超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）的变化。结果：治疗后观察组创面愈合总有效率明显高于对照组（P<0.01）。2组病人治疗前后创面组织病原致病菌差异均无统计学意义（P>0.05）。2组病人治疗后创面细菌菌落计数差值差异有统计学意义（P<0.01）。治疗后2组hs-CRP、IL-6、PCT均降低（P<0.05），且观察组下降更为显著（P<0.05~P<0.01）。结论：陈兰花颗粒外用治疗可抑制糖尿病足慢性创面细菌生物膜炎症因子表达，协同抗生素清除细菌生物膜，疗效显著。

English Abstract

Clinical study of Chenlanhua granules combined with antibiotics in the treatment of bacterial biofilm of chronic wounds in diabetic foot

Corresponding author: ZHONG Ping, 主任医师.zphgl@163.com

1. Department of Circulatory, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai 20082, China;
2. Department of Encephalopathy, Shanghai TCM-Integrated Hospital, Shanghai University of TCM, Shanghai 20082, China

Received Date: 2016-05-18

Abstract: Objective: To investigate the inhibiting effects of Chenlanhua granules combined with antibiotics on bacterial biofilm of chronic wounds in diabetic foot.Methods: Seventy-one patients with chronic wounds of diabetic feet were randomly divided into the observation group(35 cases) and control group(36 cases).The control group were treated with 0.9% sodium chloride injection by external use,and the observation group were additionally treated with Chenlanhua granules based on the control group for 2 weeks.The bacterial detection rate,colony count,and the levels of serum high sensitive C reactive protein(hs-CRP),interleukin-6(IL-6) and procalcitonin(PCT)in two groups were observed before and after treatment.Results: After treatment,the total healing rate of wounds in observation group was significantly higher than that in control group(P<0.01).The differences of the pathogenic bacteria of wounds between before and after treatment were not statistically significant in two groups(P>0.05).The difference of the D-value of colony count of wounds between two groups was statistically significant after treatment(P<0.01).The levels of hs-CRP,IL-6 and PCT in two groups significantly decreased(P<0.05),and the decreasing degrees of whose in observation group were more obvious(P<0.05 to P<0.01).Conclusions: The treatment of diabetic foot chronic wounds with Chen Lanhua granules can inhibit the expression of inflammatory factor and remove the bacterial biofilm in synergy with antibiotic,the curative effect of which is significant.