铁代谢与冠状动脉狭窄的相关性分析
Correlation between iron metabolism and coronary artery stenosis
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摘要: 目的：探讨铁代谢相关指标与冠心病（CHD）病人冠状动脉狭窄的相关性。方法：选取94例CHD病人作为观察组，非CHD病人94例作为对照组，检测其铁代谢相关指标血清铁蛋白（SF）、总铁结合力（TIBC）、SF/TIBC水平并进行分析。结果：观察组SF、SF/TIBC显著高于对照组，TIBC显著低于对照组（P<0.01）。冠状动脉轻度狭窄组、中度狭窄组、重度狭窄组之间SF、TIBC、SF/TIBC差异均有统计学意义（P<0.01），两两比较显示，重度狭窄组SF、SF/TIBC高于中度狭窄组、轻度狭窄组，TIBC低于中度狭窄组、轻度狭窄组（P<0.05和P<0.01）；中度狭窄组SF/TIBC显著高于轻度狭窄组，TIBC显著低于轻度狭窄组（P<0.01）。CHD病人Gensini评分与SF、SF/TIBC呈显著正相关关系（r=0.419、0.624，P<0.05），与TIBC呈显著负相关关系（r=-0.347，P<0.05）。结论：铁超负荷与CHD病人冠状动脉狭窄密切相关，CHD病人应定期进行铁代谢指标检测。Abstract: Objective:To explore the correlation between iron metabolism and coronary artery stenosis in patients with coronary heart disease(CHD).Methods:Ninety-four CHD patients and 94 non-CHD patients were divided into the observation group and control group,respectively.The serum ferritin(SF) level and total iron binding capacity(TIBC) and ratio of SF/TIBC between two groups were compared.Results:The SF level and ratio of SF/TIBC in observation group were significantly higher than those in control group,and the TIBC in observation group was significantly lower than that in control group(P<0.01).The differences of the SF level,TIBC and ratio of SF/TIBC between mild stenosis group,moderate stenosis group and severe stenosis group were statistically significant(P<0.01).The results of pairwise comparison showed that the SF level and ratio of SF/TIBC in severe stenosis group were higher than those in mild stenosis group and moderate stenosis group,the TIBC in severe stenosis group was lower than that in other two groups(P<0.05 and P<0.01).The ratio of SF/TIBC in moderate stenosis group was higher than that in mild stenosis group,and the TIBC in moderate stenosis group was significantly lower than that in mild stenosis group(P<0.01).The Gensini score in CHD patients was significantly positive correlated with SF level and ratio of SF/TIBC(r=0.419,r=0.624,P<0.05),and significantly negatively correlated with TIBC(r=-0.347,P<0.05).Conclusions:Iron overload is closely associated with coronary artery stenosis in CHD patients.The iron metabolism indexes should be regularly detected in CHD patients.
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Key words:
- coronary heart disease /
- iron metabolism /
- coronary artery stenosis
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