改进养膜方联合雌激素对肾虚血瘀型薄型子宫内膜病人子宫内膜容受性和子宫血流动力学的影响
Effect of the modified Yangmo decoction combined with estrogen on endometrial receptivity and uterine hemodynamics in patients with kidney deficiency and blood stasis type thin endometrium
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摘要: 目的：研究改进养膜方联合雌激素对肾虚血瘀型薄型子宫内膜病人子宫内膜容受性和子宫血流动力学的影响。方法：70例肾虚血瘀型薄型子宫内膜病人随机分为联合组与对照组，每组35例。对照组给予雌激素补充治疗，联合组在对照组基础上加用改进养膜方，比较2组性激素、子宫内膜血管内皮生长因子、子宫血流动力学、子宫内膜厚度与形态、妊娠结局及不良反应。结果：2组治疗3个月后雌二醇、血管内皮生长因子表达、子宫螺旋动脉阻力指数和子宫内膜厚度差异有统计学意义（P<0.01）。联合组治疗后子宫内膜形状A型和B型比例增加，C型降低，与治疗前差异有统计学意义（P<0.01）。结论：改进养膜方联合雌激素可以改善子宫内膜血液供应，促进子宫内膜生长发育，改善子宫内膜容受性。Abstract: Objective:To investigate the effects of the modified Yangmo decoction combined with estrogen on the endometrial receptivity and uterine hemodynamics in patients with kidney deficiency and blood stasis type thin endometrium.Methods:Seventy patients with kidney deficiency and blood stasis type thin endometrium were randomly divided into the combined group and control group(35 cases each group).The control group were treated with estrogen supplement,and the combined group were additionally treated with the modified Yangmo decoction based on the control group.The levels of sex hormone and endometrial vascular endothelial growth factor,uterine hemodynamics,endometrial thickness and shape,pregnancy outcome,and adverse reactions between two groups were compared.Results:After 3 months of treatment,the differences of the levels of estradiol and endometrial vascular endothelial growth factor,uterine spiral artery resistance index and endometrial thickness between two groups were statistically significant(P<0.01).The ratios of type A and type B endometrium,and ratio of type C in combined group increased and decreased after treatment,respectively(P<0.01).Conclusions:The modified Yangmo decoction combined with estrogen can improve the endometrial blood supply,promote endometrial growth and improve endometrial receptivity.
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[1] 余小英,马科,胡卫华,等.复方玄驹胶囊联合小剂量雌激素治疗肾阳虚型薄型子宫内膜不孕症患者的临床疗效观察[J].生殖与避孕,2015,35(9):612. [2] 赵诗艺,刘英,杨晓葵,等.薄型子宫内膜冻融胚胎移植周期中应用雌二醇/雌二醇地屈孕酮的疗效观察[J].实用妇产科杂志,2015,31(4):270. [3] 乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:415. [4] 欧阳惠卿.中医妇科学[M].北京:人民卫生出版社,2004:224. [5] GONEN Y,CASPER RF.Prediction of implantation by the sonographic appearance of the endometrium during controlled ovarian stimulation for in vitro fertilization(IVF)[J].J In Vitro Fert Embryo Transf,1990,7(3):146. [6] 田野.自拟补肾活血煎剂联合雌孕激素序贯疗法对宫腔粘连术后子宫内膜影响的临床研究[J].四川中医,2016,34(12):126. [7] 潘平山,杨钦灵,王立芳.体外受精-胚胎移植(IVF-ET)术后早期流产病人的相关因素分析[J].解放军医药杂志,2016,28(8):48. [8] 高新源,许丽绵.许丽绵教授补肾活血法改善子宫内膜容受性经验介绍[J].四川中医,2015,33(6):1. [9] 张来宾,吕洁丽,陈红丽,等.当归中苯酞类成分及其药理作用研究进展[J].中国中药杂志,2016,41(2):167. [10] 冯晗,周宏灏,欧阳冬生.杜仲的化学成分及药理作用研究进展[J].中国临床药理学与治疗学,2015,20(6):713. [11] 袁媛,吴芹,石京山,等.丹参及其主要成分保肝作用的研究进展[J].中国中药杂志,2015,40(4):588. [12] 程博琳,苗明三.阿胶的现代研究及特点[J].中医学报,2015,30(3):415. [13] 徐何方,杨颂,李莎莎,等.菟丝子醇提物对肾阳虚证模型大鼠免疫功能的影响[J].中药材,2015,38(10):2163. [14] 李玉琴,郭红,俄洛吉,等.淫羊藿苷对E2诱发去势大鼠子宫内膜渗出的干预作用研究[J].中国妇幼保健,2016,31(5):1039. [15] 王银娟,陆崟,汪玥,等.紫元胶囊的质量标准研究[J].中国医药导报,2015,12(18):89. [16] 潘佳,马汝婵,陈友国,等.VEGF、IL-6、IL-8在子宫内膜异位症患者血清和腹腔液中的表达[J].湖南师范大学学报(医学版),2015,12(5):15. [17] 吴海燕,徐瑶,郭燕华.大黄素对子宫内膜异位症患者卵泡刺激素、黄体生成素及雌二醇水平的影响[J].西部医学,2016,28(1):102. [18] 常林利,刘晓蓉,刘俊,等.益母草颗粒对人工流产术后患者血清雌激素水平及子宫内膜修复的影响[J].医学临床研究,2015,32(9):1755. [19] 何爱桦,李毅芳.来曲唑对PCOS患者子宫内膜容受性及E2、PRL、LH、FSH激素水平变化的影响[J].湖南师范大学学报(医学版),2017,14(1):124. [20] 简勤勤,白峻虎.妇科再造胶囊联合来曲唑治疗无排卵性不孕症临床分析[J].解放军医药杂志,2016,28(2):96. [21] 许娟,唐淮云,汤丽莎,等.温经祛瘀方对子宫内膜病变不孕患者IVF-ET周期子宫内膜形态变化及妊娠的影响[J].山东医药,2015,55(5):19. -
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