烫伤后血浆及水泡液中白细胞介素-6、硫酸乙酰肝素酶变化的临床研究

吴晓; 董言斌; 刘岳鹏; 陈兆永; 何学明

doi:10.13898/j.cnki.issn.1000-2200.2018.02.012

烫伤后血浆及水泡液中白细胞介素-6、硫酸乙酰肝素酶变化的临床研究

1. 蚌埠医学院附属连云港市东方医院转化医学中心, 江苏连云港 222042;
2. 蚌埠医学院附属连云港市东方医院烧伤科, 江苏连云港 222042;
3. 蚌埠医学院附属连云港市东方医院老年科, 江苏连云港 222042

作者简介: 吴晓(1991-),女,硕士研究生.

基金项目:
江苏省连云港市科技计划项目（SH1821）
中图分类号: R644

The level changes of interleukin-6 and heparin sulfate in plasma and blister fluid after scald

1. Translational Medicine Center, Lianyungang Eastern Hospital Affiliated to Bengbu Medical College, Lianyungang Jiangsu 222042, China;
2. Department of Burn, Lianyungang Eastern Hospital Affiliated to Bengbu Medical College, Lianyungang Jiangsu 222042, China;
3. Department of Geriatrics, Lianyungang Eastern Hospital Affiliated to Bengbu Medical College, Lianyungang Jiangsu 222042, China
CLC number: R644

摘要: 目的：分析烫伤后血浆及水泡液中白细胞介素-6（IL-6）、硫酸乙酰肝素酶（HPSE）水平的变化，探究二者与烫伤创面深度及严重程度的关系。方法：根据烫伤深度，把39例烫伤病人分为浅Ⅱ度组和深Ⅱ度组，共纳入研究中水泡液样本为浅Ⅱ度23例和深Ⅱ度21例，血浆样本为浅Ⅱ度18例和深Ⅱ度16例，采用酶联免疫吸附法检测烫伤病人第1、3、5天血浆及水泡液中IL-6、HPSE水平。结果：烫伤病人水泡液中IL-6、HPSE水平明显高于血浆中（P<0.01）。深Ⅱ度烫伤病人水泡液中IL-6水平明显高于浅Ⅱ度烫伤病人（P<0.01），而HPSE水平低于深Ⅱ度烫伤病人（P<0.05~P<0.01）。结论：烫伤早期水泡中IL-6水平与烫伤深度及病情严重程度正相关，烫伤程度越深，IL-6水平越高。烫伤早期水泡液中HPSE水平与创面愈合时间负相关。HPSE水平越高，提示创面后期愈合越好，所需时间越短。
- 烫伤 /
- 水泡液 /
- 白细胞介素-6 /
- 硫酸乙酰肝素酶 /
- 烫伤深度 /
- 创面愈合
Abstract: Objective: To explore the level changes of interleukin-6(IL-6) and heparin sulfate(HPSE) in plasma and blister fliud after scald,and relationship between levels of IL-6,HPSE and depth and severity of the scald wound.Methods: According to the depth of scald,39 scald patients were divided into the superficial Ⅱ degree group and deep Ⅱ degree group.Among the blister specimens,superficial Ⅱ degree in 23 cases and deep Ⅱ degree in 21 cases,and superficial Ⅱ degree in 18 cases and deep Ⅱ degree in 16 cases in plasma specimens were investigated.The levels IL-6 and HPSE in plasma and blister fluid were detected using enzyme-linked immunosorbent assay(EⅡSA) after 1,3 and 5d of scald.Results: The levels of IL-6 and HPSE in blister fluid were significantly higher than those in plasma in scald patients(P<0.01).The level of IL-6 in blister fluid of patients with deep Ⅱ degree scald was significantly higher than that of patients with superficial Ⅱ degree scald patients(P<0.01),and the level of HPSE in blister fluid of patients with deep Ⅱ degree scald was significantly lower than that of patients with superficial Ⅱ degree scald patients(P<0.01 to P<0.05).Conclusions: The level of IL-6 in blister fluid at the early stage of scald is positively related to the depth and severity of scald.The more severe scald are,the higher the level of IL-6 is.The level of HPSE in blister fluid at the early stage of scald is negatively related to the time of wound healing.The bigger the scald area is,the better the healing is,and the shorter the time is.
- scald /
- blister fluid /
- inkerleukin-6 /
- heparanase /
- burn depth /
- wound healing

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烫伤后血浆及水泡液中白细胞介素-6、硫酸乙酰肝素酶变化的临床研究

作者简介: 吴晓(1991-),女,硕士研究生.

The level changes of interleukin-6 and heparin sulfate in plasma and blister fluid after scald

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烫伤后血浆及水泡液中白细胞介素-6、硫酸乙酰肝素酶变化的临床研究

作者简介: 吴晓(1991-),女,硕士研究生.

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The level changes of interleukin-6 and heparin sulfate in plasma and blister fluid after scald

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烫伤后血浆及水泡液中白细胞介素-6、硫酸乙酰肝素酶变化的临床研究

作者简介: 吴晓(1991-),女,硕士研究生.

The level changes of interleukin-6 and heparin sulfate in plasma and blister fluid after scald

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烫伤后血浆及水泡液中白细胞介素-6、硫酸乙酰肝素酶变化的临床研究

作者简介: 吴晓(1991-),女,硕士研究生.

English Abstract

The level changes of interleukin-6 and heparin sulfate in plasma and blister fluid after scald

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目录