Surgisis在蹄铁形肛瘘术后深部组织缺损修复中的临床效果
Application effect of Surgisis in the deep tissue defect repair after horseshoe anal fistula
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摘要: 目的:探讨Surgisis在蹄铁形肛瘘术后深部组织缺损修复中的临床效果。方法:选取蹄铁形肛瘘病人60例,随机分为观察组和对照组,各30例。对照组常规换药,待创面肉芽新鲜后继续常规换药;观察组先行常规换药,待创面肉芽新鲜后"皮岛式"贴植入Surgisis支架。比较2组治愈率、创面愈合时间、术后并发症情况和病人VAS评分、瘢痕面积,同时采用HE染色和免疫组织化学法分别对治疗后肉芽组织血管数目及VEGF表达进行检测。结果:与对照组比较,观察组治愈率明显升高(P<0.01),愈合时间明显缩短(P<0.01),治疗后肉芽组织血管数和VEGF表达均明显增加(P<0.01)。观察组肛门受损率为0.00%(0/30),明显低于对照组的36.67%(11/30)(P<0.01)。且观察组病人VAS评分明显低于对照组(P<0.01),瘢痕面积明显小于对照组(P<0.01)。结论:Surgisis支架应用于蹄铁形肛瘘术后深部组织缺损修复,能够促进创面毛细血管生成,改善创面微循环,加速创面愈合,值得临床推广使用。
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关键词:
- 蹄铁形肛瘘 /
- 组织修复 /
- Surgisis生物医用材料
Abstract: Objective: To explore the application effects of Surgisis in the deep tissue defect repair after horseshoe anal fistula.Methods: Sixty patients with horseshoe anal fistula were randomly divided into the observation group and control group(30 cases each group).The control group was treated with routine wound dressing.The observation group was treated with routine wound dressing at first,and then the Surgisis stent of skin island patch was implanted after wound granulation fresh.The cure rate,wound healing time,postoperative complications,VAS score and scare area between two groups were compared.The number of granulation tissue and VEGF expression after treatment were detected using HE staining and IHC.Results: Compared with the control group,the cure rate significantly decreased(P<0.01),the healing time significantly shortened,and the number of granulation tissue and VEGF expression after treatment significantly increased in observation group(P<0.01).The anal damage rate and VAS score in observation group were significantly lower than those in control group(P<0.01),and scare area in observation group was significantly less than that in control group(P<0.01).Conclusions: The application of Surgisis stent in postoperative deep tissue defect repair of horseshoe anal fistula can promote the wound capillary generation,improve the wound microcirculation and speed up the wound healing,which is worthy of clinical use.-
Key words:
- horseshoe anal fistula /
- tissue recovery /
- Surgisis biomedical materials
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