地塞米松联合环孢素治疗老年免疫性血小板减少症的疗效观察

马圣宇

doi:10.13898/j.cnki.issn.1000-2200.2018.05.012

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地塞米松联合环孢素治疗老年免疫性血小板减少症的疗效观察

马圣宇

文章导航 > 蚌埠医学院学报 > 2018, 43 > 5: (606-607,610)

引用本文:

Citation:

地塞米松联合环孢素治疗老年免疫性血小板减少症的疗效观察

马圣宇

安徽省宿州市立医院血液科, 234000

作者简介: 马圣宇(1972-),男,副主任医师.

中图分类号: R558.2

Clinical effect of dexamethasone combined with cyclosporine in the treatment of immune thrombocytopenia in elderly patients

MA Sheng-yu

Department of Hematology, Suzhou Municiple Hospital, Suzhou Anhui 234000, China
CLC number: R558.2

摘要: 目的：探讨大剂量地塞米松联合环孢素治疗老年免疫性血小板减少症（ITP）近期及远期的疗效。方法：将24例老年ITP随机分成对照组12例（地塞米松40 mg/d，4 d），观察组12例（地塞米松40 mg/d，4 d，联合环孢素3 mg·kg^-1·d^-1）。观察治疗后近期（1周、2周）和远期（1个月）外周血血小板水平及不良反应。结果：治疗前和治疗后7 d 2组血小板水平差异均无统计学意义（P>0.05）；治疗后14 d和1个月，观察组血小板水平显著高于对照组（P<0.01）；且2组治疗前后不同时刻差异均有统计学意义（P<0.01），2组治疗后7 d、14 d和1个月均显著高于治疗前（P<0.01），而对照组治疗后14 d显著低于治疗后7 d （P<0.01）。2组不良反应差异无统计学意义（P>0.05）。结论：地塞米松联合环孢素能提高老年ITP近期和远期疗效，且不良反应轻微。
- 免疫性血小板减少症 /
- 地塞米松 /
- 环孢素
Abstract: Objective: To investigate the short and long-term efficacy of high dose dexamethasone combined with cyclosporine in the treatment of immune thrombocytopenia(ITP) in elderly patients.Methods: Twenty-four elderly patients with ITP were randomly divided into the control group(12 cases treated with 40 mg/d of dexamethasone for 4 d) and observation group(12 cases treated with 40 mg/d of dexamethasone for 4 d combined with 3 mg·kg^-1·d^-1 of cyclosporine).The platelet levels and adverse reactions in two groups were observed after 1 week,2 weeks and 1 month of treatment.Results: The differences of the levels of platelet before,and after 7 d of treatment between two groups were not statistically significant(P>0.05).After 14 days and 1 month of treatment,the levels of platelet in observation group were significantly higher than that in control group(P<0.01),and the differences of the levels of platelet at different time-points between two groups were statistically significant(P<0.01).After 7 d,14 d and 1 month of treatment,the levels of platelet in two groups were significantly higher than that before treatment(P<0.01),and the level of platelet in control group after 14 d of treatment was significantly lower than that after 7 d of treatment(P<0.01).The difference of the adverse reaction between two groups was not statistically significant(P>0.05).Conclusions: The dexamethasone combined with cyclosporine can improve the short-term and long-term efficacy of elderly patients with ITP,and the adverse reaction of which is minute.
- immune thrombocytopenia /
- dexamethasone /
- cyclosporine

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地塞米松联合环孢素治疗老年免疫性血小板减少症的疗效观察

马圣宇

作者简介: 马圣宇(1972-),男,副主任医师.

安徽省宿州市立医院血液科, 234000

收稿日期: 2017-01-18
录用日期: 2017-10-27

关键词:

摘要: 目的：探讨大剂量地塞米松联合环孢素治疗老年免疫性血小板减少症（ITP）近期及远期的疗效。方法：将24例老年ITP随机分成对照组12例（地塞米松40 mg/d，4 d），观察组12例（地塞米松40 mg/d，4 d，联合环孢素3 mg·kg^-1·d^-1）。观察治疗后近期（1周、2周）和远期（1个月）外周血血小板水平及不良反应。结果：治疗前和治疗后7 d 2组血小板水平差异均无统计学意义（P>0.05）；治疗后14 d和1个月，观察组血小板水平显著高于对照组（P<0.01）；且2组治疗前后不同时刻差异均有统计学意义（P<0.01），2组治疗后7 d、14 d和1个月均显著高于治疗前（P<0.01），而对照组治疗后14 d显著低于治疗后7 d （P<0.01）。2组不良反应差异无统计学意义（P>0.05）。结论：地塞米松联合环孢素能提高老年ITP近期和远期疗效，且不良反应轻微。

English Abstract

Clinical effect of dexamethasone combined with cyclosporine in the treatment of immune thrombocytopenia in elderly patients

MA Sheng-yu

Department of Hematology, Suzhou Municiple Hospital, Suzhou Anhui 234000, China

Received Date: 2017-01-18
Accepted Date: 2017-10-27

Abstract: Objective: To investigate the short and long-term efficacy of high dose dexamethasone combined with cyclosporine in the treatment of immune thrombocytopenia(ITP) in elderly patients.Methods: Twenty-four elderly patients with ITP were randomly divided into the control group(12 cases treated with 40 mg/d of dexamethasone for 4 d) and observation group(12 cases treated with 40 mg/d of dexamethasone for 4 d combined with 3 mg·kg^-1·d^-1 of cyclosporine).The platelet levels and adverse reactions in two groups were observed after 1 week,2 weeks and 1 month of treatment.Results: The differences of the levels of platelet before,and after 7 d of treatment between two groups were not statistically significant(P>0.05).After 14 days and 1 month of treatment,the levels of platelet in observation group were significantly higher than that in control group(P<0.01),and the differences of the levels of platelet at different time-points between two groups were statistically significant(P<0.01).After 7 d,14 d and 1 month of treatment,the levels of platelet in two groups were significantly higher than that before treatment(P<0.01),and the level of platelet in control group after 14 d of treatment was significantly lower than that after 7 d of treatment(P<0.01).The difference of the adverse reaction between two groups was not statistically significant(P>0.05).Conclusions: The dexamethasone combined with cyclosporine can improve the short-term and long-term efficacy of elderly patients with ITP,and the adverse reaction of which is minute.