糖尿病酮症酸中毒病人校正钠水平与病情的相关性研究

查秀婧; 毕娅欣

doi:10.13898/j.cnki.issn.1000-2200.2018.08.010

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糖尿病酮症酸中毒病人校正钠水平与病情的相关性研究

查秀婧 , 毕娅欣

文章导航 > 蚌埠医学院学报 > 2018, 43 > 8: (1013-1015)

引用本文:

Citation:

糖尿病酮症酸中毒病人校正钠水平与病情的相关性研究

查秀婧¹,
毕娅欣^2, ,

1. 蚌埠医学院第二附属医院内分泌科, 安徽蚌埠 233040;
2. 蚌埠医学院第一附属医院内分泌科, 安徽蚌埠 233004

作者简介: 查秀婧(1983-),女,主治医师.

通讯作者: 毕娅欣, 主任医师.13004093815@163.com

中图分类号: R587.2

The correlation between the corrected serum sodium level and illness severity in patients with diabetic ketoacidosis

ZHA Xiu-jing¹,
BI Ya-xin^2, ,

1. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040;
2. Department of Endocrinology and Metabolism, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Corresponding author: BI Ya-xin, 主任医师.13004093815@163.com

CLC number: R587.2

摘要: 目的：探讨糖尿病酮症酸中毒（DKA）病人校正钠水平与病情的相关性。方法：回顾性分析134例确诊为DKA病人的临床资料，按照血清钠计算后的校正钠水平分为G1组（高钠组Na>150 mmol/L）；G2组（正常血钠组Na 135~<150 mmol/L）；G3组（轻度低钠组Na 125~<135 mmol/L）；G4组（重度低钠组Na<125 mmol/L）。比较各组血浆渗透压、血糖、低血压克发生率、意识障碍发生率、动脉血pH以及HCO₃^-浓度。结果：在G2、G3及G4组中，随着校正钠水平逐渐降低，病人血浆渗透压逐渐下降、动脉血pH逐渐下降、HCO₃^-浓度下降，血糖逐渐升高（P<0.01），但低血压休克发生率差异无统计学意义（P>0.05）。G1组和G3组病人的血糖、动脉血pH及HCO₃^-浓度差异均无统计学意义（P>0.05）。G1组中有2例病人死亡，余各组病人均未出现死亡病例。随着治疗后校正钠水平下降，G1组病人血糖下降、血HCO₃^-浓度升高（P<0.01）。结论：校正钠可作为评估DKA病情的评估工具，尤其是在校正钠为高钠水平的病人中。
- 糖尿病酮症酸中毒 /
- 校正钠水平 /
- 相关性
Abstract: Objective:To discuss the correlation between the corrected serum sodium level and illness severity in patients with diabetic ketoacidosis(DKA).Methods:The clinical data of 134 patients with DKA were retrospectively analyzed.According to the corrected serum sodium level,the patients were divided the group G1(corrected Na level>150 mmol/L),group G2(135 mmol/L ≤ corrected Na level<150 mmol/L),group G3(125 mmol/L ≤ corrected Na level <135 mmol/L) and group G4(corrected Na level < 125 mmol/L).The plasma osmotic pressure,blood glucose,incidence rate of low blood pressure shock,incidence rate of consciousness disturbance,pH value of artery blood and HCO₃^- levels in all groups were compared.Results:Among G2,G3 and G4 groups,with the decreasing of the corrected serum sodium level,the plasma osmotic pressure,arterial blood pH and concentration of HCO₃^- gradually decreased,and the level of blood glucose gradually increased(P<0.01).But the incidence rates of blood pressure shock and disturbance of consciousness did not shon statistical difference(P>0.05).There was no statistical significance in levels of blood glucose,arterial blood pH and concentration of HCO₃^- between group G1 and group G3(P>0.05).Two cases died in group G1,and no death case was found in other groups.With the corrected serum sodium level decreasing in group G1,the blood glucose gradually decreased,and the concentration of HCO₃^- gradually increased(P<0.01).Conclusions:The corrected sodium level can be used as a tool to evaluate illness severity in DKA patient with high sodium level.
- diabetic ketoacidosis /
- corrected serum sodium level /
- correlation

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糖尿病酮症酸中毒病人校正钠水平与病情的相关性研究

查秀婧¹
毕娅欣^2, ,

通讯作者: 毕娅欣, 主任医师.13004093815@163.com

作者简介: 查秀婧(1983-),女,主治医师.

1. 蚌埠医学院第二附属医院内分泌科, 安徽蚌埠 233040;
2. 蚌埠医学院第一附属医院内分泌科, 安徽蚌埠 233004

收稿日期: 2017-12-12
录用日期: 2018-06-04

关键词:

摘要: 目的：探讨糖尿病酮症酸中毒（DKA）病人校正钠水平与病情的相关性。方法：回顾性分析134例确诊为DKA病人的临床资料，按照血清钠计算后的校正钠水平分为G1组（高钠组Na>150 mmol/L）；G2组（正常血钠组Na 135~<150 mmol/L）；G3组（轻度低钠组Na 125~<135 mmol/L）；G4组（重度低钠组Na<125 mmol/L）。比较各组血浆渗透压、血糖、低血压克发生率、意识障碍发生率、动脉血pH以及HCO₃^-浓度。结果：在G2、G3及G4组中，随着校正钠水平逐渐降低，病人血浆渗透压逐渐下降、动脉血pH逐渐下降、HCO₃^-浓度下降，血糖逐渐升高（P<0.01），但低血压休克发生率差异无统计学意义（P>0.05）。G1组和G3组病人的血糖、动脉血pH及HCO₃^-浓度差异均无统计学意义（P>0.05）。G1组中有2例病人死亡，余各组病人均未出现死亡病例。随着治疗后校正钠水平下降，G1组病人血糖下降、血HCO₃^-浓度升高（P<0.01）。结论：校正钠可作为评估DKA病情的评估工具，尤其是在校正钠为高钠水平的病人中。

English Abstract

The correlation between the corrected serum sodium level and illness severity in patients with diabetic ketoacidosis

ZHA Xiu-jing¹
BI Ya-xin^2, ,

Corresponding author: BI Ya-xin, 主任医师.13004093815@163.com

1. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233040;
2. Department of Endocrinology and Metabolism, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, China

Received Date: 2017-12-12
Accepted Date: 2018-06-04

Abstract: Objective:To discuss the correlation between the corrected serum sodium level and illness severity in patients with diabetic ketoacidosis(DKA).Methods:The clinical data of 134 patients with DKA were retrospectively analyzed.According to the corrected serum sodium level,the patients were divided the group G1(corrected Na level>150 mmol/L),group G2(135 mmol/L ≤ corrected Na level<150 mmol/L),group G3(125 mmol/L ≤ corrected Na level <135 mmol/L) and group G4(corrected Na level < 125 mmol/L).The plasma osmotic pressure,blood glucose,incidence rate of low blood pressure shock,incidence rate of consciousness disturbance,pH value of artery blood and HCO₃^- levels in all groups were compared.Results:Among G2,G3 and G4 groups,with the decreasing of the corrected serum sodium level,the plasma osmotic pressure,arterial blood pH and concentration of HCO₃^- gradually decreased,and the level of blood glucose gradually increased(P<0.01).But the incidence rates of blood pressure shock and disturbance of consciousness did not shon statistical difference(P>0.05).There was no statistical significance in levels of blood glucose,arterial blood pH and concentration of HCO₃^- between group G1 and group G3(P>0.05).Two cases died in group G1,and no death case was found in other groups.With the corrected serum sodium level decreasing in group G1,the blood glucose gradually decreased,and the concentration of HCO₃^- gradually increased(P<0.01).Conclusions:The corrected sodium level can be used as a tool to evaluate illness severity in DKA patient with high sodium level.