胃蛋白酶原及胃泌素-17检测在胃肠疾病诊断中的作用
The value of the detection of pepsinogen and gastrin-17 in the diagnosis of astrointestinal diseases
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摘要: 目的:分析胃蛋白酶原和胃泌素-17在胃肠疾病中的诊断价值。方法:选取80例胃肠疾病病人作为观察组,80例非胃肠疾病病人作为对照,采用酶联免疫吸附法进行胃蛋白酶原1(PGⅠ)、胃蛋白酶原2(PGⅡ)、胃泌素-17等的检测,比较2组胃蛋白酶原和胃泌素-17水平的变化。结果:观察组病人的胃蛋白酶原以及胃泌素-17检测水平均明显高于对照组(P<0.01),而PGⅠ/PGⅡ比值明显低于对照组(P<0.01);胃炎病人PGⅠ、胃泌素-17水平高于十二指肠溃疡、胃溃疡病人,PGⅡ水平、PGⅠ/PGⅡ水平低于十二指肠溃疡、胃溃疡病人(P<0.05);十二指肠溃疡病人与胃溃疡病人PGⅠ水平接近(P>0.05);十二指肠溃疡病人胃泌素-17水平明显低于胃炎和胃溃疡病人(P<0.05),胃溃疡病人PGⅠ/PGⅡ水平高于胃炎、十二指肠溃疡病人(P<0.05),胃炎组与十二指肠溃疡组PGⅠ/PGⅡ水平接近(P>0.05)。结论:胃蛋白酶原和胃泌素-17在胃肠疾病中的诊断中具有一定的价值,临床上可以广泛应用。Abstract: Objective:To analyze the diagnostic value of the pepsinogen and gastrin-17 in gastrointestinal diseases.Methods:Eighty patients with gastrointestinal diseases and 80 patients without gastrointestinal diseases were divided into the observation group and control group,respectively.The levels of pepsinogen Ⅰ,pepsinogen Ⅱ and gastrin -17 in two groups were detected using enzyme linked immunosorbent assay(ELISA),and the levels of pepsinogen and gastrin-17 between two groups were compared.Results:The levels of pepsinogen and gastrin-17 in observation group were significantly higher than those in control group(P<0.01),but the ratio of PGⅠ/PGⅡ in observation group was significantly lower than that in control group(P<0.01).The levels of PGⅠ and gastrin-17 in patients with gastritis were significantly higher than those in patients with duodenal ulcer or gastric ulcer,but the levels of PGⅡ and PGⅠ/PGⅡ in patients with gastritis were significantly lower than those in patients with duodenal ulcer or gastric ulcer(P<0.05).The level of PGⅠ in patients with duodenal ulcer was similar to the patients with gastric ulcer(P>0.05).The level of gastrin-17 in patients with duodenal ulcer was significantly lower than that in patients with gastritis or gastric ulcer(P<0.05).The ratio of PGⅠ/PGⅡ in patients with gastric ulcer was significantly higher than that in patients with gastritis or duodenal ulcer(P<0.05),and the ratio of PGⅠ/PGⅡ in patients with gastritis was similar to the patients with duodenal ulcer(P>0.05).Conclusions:The levels of pepsinogen and gastrin-17 have certain value in the diagnosis of gastrointestinal diseases,which can be widely used in clinic.
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Key words:
- gastrointestinal disease /
- pepsinogen /
- gastrin-17
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