血清癌胚抗原与溶血磷脂酸联合检测在非小细胞肺癌病人中的应用
Application value of the joint detection of serum carcinoembryonic antigen and lysophosphatidic acid in patients with non-small cell lung cancer
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摘要: 目的：探讨血清癌胚抗原（CEA）与溶血磷脂酸（LPA）在非小细胞肺癌病人中的应用价值。方法：选取84例非小细胞肺癌病人（非小细胞肺癌组）、84例肺炎病人（肺炎组）和84名健康体检者（对照组），分别测定和比较3组人群的血清CEA和LPA水平。分析血清CEA和LPA联合检测对非小细胞肺癌的诊断价值。结果：非小细胞肺癌病人血清CEA和LPA水平显著高于肺炎病人和健康体检者（P<0.01）；腺癌组病人血清CEA阳性率（62.5%）显著高于鳞状细胞癌组和组织未分型组病人（P<0.05），另外LPA在3组非小细胞肺癌病人血清中的阳性率相当（45.00%～54.55%），3组间差异无统计学意义（P>0.05）；CEA与LPA在诊断非小细胞肺癌中的效能结果显示，血清CEA单独检测阳性率为31.35%，LPA单独检测阳性率为30.16%，两者联合检测阳性率为38.89%。血清CEA准确度为67.86%，特异度为74.60%，灵敏度为50.40%； LPA准确度为64.68%，特异度为72.62%，灵敏度为42.86%；两者联合检测准确度提高到69.44%，灵敏度提高到60.71%，特异度也达到了70.24%。结论：血清CEA和LPA联合检测有利于提高非小细胞肺癌诊断的灵敏度和准确度，值得临床推广。Abstract: Objective:To explore the application value of the joint detection of serum carcinoembryonic antigen(CEA) and lysophosphatidic acid(LPA) in patients with non-small cell lung cancer.Methods:Eighty-four patients with non-small cell lung cancer,84 patients with pneumonia and 84 healthy examined people were divided into the non-small cell lung cancer group,pneumonia group and healthy control group,respectively.The serum levels of CEA and LPA in three groups were detected,and the value of the joint examination of CEA and LPA in the diagnosis of non-small cell lung cancer was analyzed.Results:The levels of serum CEA and LPA in patients with non-small cell lung were significantly higher than those in pneumonia patients and healthy examined people(P<0.01).The positive rate of serum CEA in patients with adenocarcinoma(62.5%) was significantly higher than that in squamous cell carcinoma group and undifferentiated cancer group(P<0.05),and the differences of the LPA levels in non-small cell lung cancer group,pneumonia group and healthy control group were not statistically significant(P>0.05).The positive rates of CEA,LPA,and joint detection of CEA and PLA in the diagnosis of non-small cell lung cancer were 31.35%,30.16% and 38.89%,respectively.The accuracy rate,specificity and sensitivity of CEA detection were 67.86%,74.60% and 50.40%,respectively.The accuracy rate,specificity and sensitivity of LPA detection were 64.68%,72.62% and 42.86%,respectively.The accuracy rate,specificity and sensitivity of joint detection were 69.44%,70.24% and 60.71%,respectively.Conclusions:The joint detection of serum CEA and LPA can improve the diagnostic rate of non-small cell lung cancer,which is worthy of clinical application.
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