[1]
|
LOPEZ-OTIN C,BLASCO MA,PARTRIDGE L,et al.The hallmarks of aging[J].Cell,2013,153(6):1194. |
[2]
|
CHEN J,OU Y,YANG Y,et al.KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing[J].Nature,2018,557(7706):585. |
[3]
|
KAEBERLEIN M,MCVEY M,GUARENTE L.The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms[J].Genes Dev,1999,13(19):2570. |
[4]
|
ROGINA B,HELFAND SL.Sir2 mediates longevity in the fly through a pathway related to calorie restriction[J].Proc Natl Acad Sci U S A,2004,101(45):15998. |
[5]
|
CHILDS BG,GLUSCEVIC M,BAKER DJ,et al.Senescent cells:an emerging target for diseases of ageing[J].Nat Rev Drug Discov,2017,16(10):718. |
[6]
|
RHOADS TW,BURHANS MS,CHEN VB,et al.Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys[J].Cell Metab,2018,27(3):677. |
[7]
|
HAYFLICK L,MOORHEAD PS.The serial cultivation of human diploid cell strains[J].Exp Cell Res,1961,25(3):585. |
[8]
|
VAN DEURSEN JM.The role of senescent cells in ageing[J].Nature,2014,509(7501):439. |
[9]
|
DIMRI GP,LEE X,BASILE G,et al.A biomarker that identifies senescent human cells in culture and in aging skin in vivo[J].Proc Natl Acad Sci U S A,1995,92(20):9363. |
[10]
|
SHARPLESS NE,SHERR CJ.Forging a signature of in vivo senescence[J].Nat Rev Cancer,2015,15(7):397. |
[11]
|
RODIER F,COPPE JP,PATIL CK,et al.Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion[J].Nat Cell Biol,2009,11(8):973. |
[12]
|
KUILMAN T,PEEPER DS.Senescence-messaging secretome:SMS-ing cellular stress[J].Nat Rev Cancer,2009,9(2):81. |
[13]
|
CHILDS BG,LI H,VAN DEURSEN JM.Senescent cells:a therapeutic target for cardiovascular disease[J].J Clin Invest,2018,128(4):1217. |
[14]
|
JEON OH,KIM C,LABERGE RM,et al.Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment[J].Nat Med,2017,23(6):775. |
[15]
|
CHEUNG P,VALLANIA F,WARSINSKE HC,et al.Single-cell chromatin modification profiling reveals increased epigenetic variations with aging[J].Cell,2018,173(6):1385. |
[16]
|
EMILSSON V,ILKOV M,LAMB JR,et al.Co-regulatory networks of human serum proteins link genetics to disease[J].Science,2018,361(6404):769. |
[17]
|
PARTRIDGE L,DEELEN J,SLAGBOOM PE.Facing up to the global challenges of ageing[J].Nature,2018,561(7721):45. |
[18]
|
ZHANG W,WAN H,FENG G,et al.SIRT6 deficiency results in developmental retardation in cynomolgus monkeys[J].Nature,2018,560(7720):661. |
[19]
|
GOLDMAN RD,SHUMAKER DK,ERDOS MR,et al.Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome[J].Proc Natl Acad Sci U S A,2004,101(24):8963. |
[20]
|
HAJJAR J,HABRA MA,NAING A.Metformin:an old drug with new potential[J].Expert Opin Investig Drugs,2013,22(12):1511. |
[21]
|
KANFI Y,NAIMAN S,AMIR G,et al.The sirtuin SIRT6 regulates lifespan in male mice[J].Nature,2012,483(7388):218. |
[22]
|
PLUQUET O,POURTIER A,ABBADIE C.The unfolded protein response and cellular senescence.A review in the theme:cellular mechanisms of endoplasmic reticulum stress signaling in health and disease[J].Am J Physiol Cell Physiol,2015,308(6):C415. |
[23]
|
MOLLIEX A,TEMIROV J,LEE J,et al.Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization[J].Cell,2015,163(1):123. |
[24]
|
KENNEDY BK,BERGER SL,BRUNET A,et al.Geroscience:linking aging to chronic disease[J].Cell,2014,159(4):709. |
[25]
|
ZHANG R,CHEN H,LIU DP.The Four Layers of Aging[J].Cell Systems,2015,1(3):180. |