• 中国科技论文统计源期刊
  • 中国科技核心期刊
  • 中国高校优秀期刊
  • 安徽省优秀科技期刊

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

糖化血红蛋白与冠心病病人心肌外脂肪厚度的相关性研究

范益博 ,  幺天保 ,  袁安彩 ,  邵琴 ,  卜军

downloadPDF
文章导航 > 蚌埠医学院学报  > 2018,  43 > 10: (1373-1376)  
引用本文:
shu
Citation:
shu

糖化血红蛋白与冠心病病人心肌外脂肪厚度的相关性研究

  • 1. 上海交通大学医学院附属仁济医院 心内科, 上海 200127;

  • 2. 上海交通大学 医学院, 上海 200025;

  • 3. 上海健康医学院附属浦东新区人民医院 急诊与重症医学科, 上海 201299

    • 作者简介: 范益博(1985-),男,硕士研究生,住院医师.
    通讯作者: 邵琴, 副主任医师.shaoqindr@126.com ; 
  • 基金项目:

    国家自然科学基金青年基金项目（81500221）；上海市浦东新区医学重点专科建设项目（PWZzk2017-22）

  • 中图分类号: R541.4

Study on the correlation between glycosylated hemoglobin and epicardial adipose tissue thickness in CHD patients

  • 1. Department of Cardiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127;

  • 2. School of Medicine, Shanghai Jiao Tong University, Shanghai 200025;

  • 3. Department of Emergency and Critical Care Medicine, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201299, China

    • Corresponding author: SHAO Qin, 副主任医师.shaoqindr@126.com ;

  • CLC number: R541.4

  • 摘要: 目的：探讨糖化血红蛋白水平与冠心病病人心肌外脂肪厚度（epicardial adipose tissue thickness，EATT）的关系。方法：选择入院诊断为冠心病的住院病人共510例，均行冠脉造影检查，并根据造影结果将入选者分为冠心病组和对照组。对所有入选者进行心脏多层螺旋CT扫描，根据CT图像分别测定前降支、回旋支和右冠脉区域的EATT，并计算三者的厚度之和（Total EATT），同时测定血清糖化血红蛋白等指标。结果：冠心病组平均糖化血红蛋白为（6.2±1.2）mmol/L，高于对照组的（5.8±0.8）mmol/L（P<0.01），冠心病组Total EATT（26.33±7.8）mm，高于对照组的（22.72±6.3）mm（P<0.01）。在冠心病病人中，糖化血红蛋白水平与Total EATT呈正相关关系（r=0.207，P<0.01）；多元回归分析表明，糖化血红蛋白与Total EATT呈独立正相关关系（P<0.01）。结论：冠心病病人中，EATT增加可能与糖化血红蛋白水平增高有关。
    Abstract: Objective:To explore the relationship between glycosylated hemoglobin level and epicardial adipose tissue thickness(EATT) in coronary heart disease(CHD) patients.Methods:A total of 510 patients with CHD were examined using coronary arteriography,and divided into the CHD group and control group according to the results of coronary arteriography.The EATT in anterior descending branch,cyclotron branch and right coronary artery were measured according to multilayer spiral cardiac CT scan imaging,the total thickness of the three(Total EATT) was calculated,and the lycosylated hemoglobin were measured.Results:The mean glycosylated hemoglobin level in CHD group[(6.2±1.2)mmol/L] was significantly higher than that in control group[(5.8±0.8)mmol/L])(P<0.001).The Total EATT in CHD group[(26.33±7.8)mm] was significantly higher than that in control group[(22.72±6.3)mm)](P<0.01).The glycosylated hemoglobin level was positively correlated with the Total EATT(r=0.207,P<0.01).Multivariate regression analysis showed that the glycosylated hemoglobin level was an independent predictor of Total EATT(P<0.01).Conclusions:The glycosylated hemoglobin level increasing is positively correlated with EATT in CHD patients.
  • [1] TALMAN AH,PSALTIS PJ,CAMERON JD,et al.Epicardial adipose tissue:far more than a fat depot[J].Cardiovasc Diagn Ther,2014,4(6):416.
    [2] SAM C,GARY DL,EUGENIA C.Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease[J].Am J Physiol Endocrinol Metab,2012,303:E937.
    [3] AYCAN FE,ASLI T,SINAN AK,et al.Epicardial adipose tissue thickness is an independent predictor of critical and complex coronary artery disease by gensini and syntax scores[J].Tex Heart Inst J,2016,43(1):29.
    [4] KIRAC UI,OKUTURLAR Y,DEMIR E,et al.Relationship between epicardial adipose tissue thickness and vitamin D in patients with metabolic syndrome[J].Int J Clin Exp Med,2015,8(4):5707.
    [5] GORTER PM,VAN LINDERT AS,DE VOS AM,et al.Quantification of epicardial and peri-coronary fat using cardiac comput-ed tomography;reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease[J].Atherosclerosis,2008,197:896.
    [6] YORGUN H,CANPOLAT U,HAZIROLAN T,et al.Increased epicardial fat tissue is a marker of metabolic syndrome in adult patients[J].Int J Cardiol,2013,165(2):308.
    [7] BAMBACE C,SEPE A,ZOICO E,et al.Inflammatory profile in subcutaneous and epicardial adipose tissue in men with and without diabetes[J].Heart Vessels,2014,29:42.
    [8] SHIMABUKURO M.Cardiac adiposity and global cardiometabolic risk:new concept and clinical implication[J].Circ J,2009,73:27.
    [9] KARADAG B,OZULU B,OZTURK FY,et al.Comparison of epicardial adipose tissue (EAT) thickness and anthropometric measurements in metabolic syndrome (MS) cases above and under the age of 65[J].Arch Gerontol Geriatr,2011,52:e79-84.
    [10] IACOBELLIS G,RIBAUDO MC,ASSAEL F,et al.Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome:a new indicator of cardiovascular risk[J].Clin Endocrinol Metab,2003,88(11):5163.
    [11] MOHAMMADZADEH M,MOHAMMADZADEH V,SHAKIBA M,et al.Assessing the relation of epicardial fat thickness and volume,quantified by 256-slice computed tomography scan,with coronary artery disease and cardiovascular risk factors[J].Arch Iran Med,2018,21(3):95.
    [12] BAKIRCI EM,DEGIRMENCI H,DUMAN H,et al.Increased epicardial adipose tissue thickness is associated with angiographic thrombus burden in the patients with non-st-segment elevation myocardial infarction[J].Clin Appl Thromb Hemost,2015,21(7):612.
    [13] SEKER T,TURKOGLU C,HARBALIOGLU H,et al.The impact of diabetes on the association between epicardial fat thickness and extent and complexity of coronary artery disease in patients with non-ST elevation myocardial infarction[J].Kardiol Pol,2017,75(11):1177.
    [14] SHARDA M,NIGAM H,MEENA SR,et al.Correlation and comparison of epicardial adipose tissue with sagittal abdominal diameter and other anthropometric and biochemical variables of metabolic syndrome[J].Assoc Physicians India,2017,65(5):34.
    [15] LIMA-MARTÍNEZ MM,LÓPEZ-MENDEZ G,ODREMAN R,et al.Epicardial adipose tissue thickness and its association with adiponectin in metabolic syndrome patients from Mérida,Venezuela[J].Arq Bras Endocrinol Metabol,2014,58(4):352.
    [16] OJEDA-PEÑA AC,AMADOR-LICONA N,RODRÍGUEZ-SALAZAR E,et al.Comparison of epicardial fat thickness in diabetic patients compared to non-diabetics with acute myocardial infarction and ST-segment elevation (AMI-STEMI)[J].Gac Med Mex,2016,152(3):345.
    [17] DO KS,YOUNG SH,HYEJIN L,et al.Increased epicardial adipose tissue thickness in type 2 diabetes mellitus and obesity[J].Diabetes Metab J,2015,39(5):405.
    [18] YAZICI D,ÖZBEN B,YAVUZ D,et al.Epicardial adipose tissue thickness in type 1 diabetic patients[J].Endocrine,2011,40(2):250.
    [19] REYES Y,PAOLI M,CAMACHO N,et al.Epicardial adipose tissue thickness in children and adolescents with cardiometabolic risk factors[J].Endocrinol Nutr,2016,63(2):70.
    [20] IACOBELLIS G,PISTILLI D,GUCCIARDO M,et al.Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease[J].Cytokine,2005,29:251.
    [21] JEEHOON K,YOUNG CK,JIN JP,et al.Increased epicardial adipose tissue thickness is a predictor of new-onset diabetes mellitus in patients with coronary artery disease treated with high-intensity statins[J].Cardiovasc Diabetol,2018,17:10.
    [22] NASARRE L,JUAN BO,GASTELURRUTIA P,et al.Low density lipoprotein receptor-related protein 1 is upregulated in epicardial fat from type 2 diabetes mellitus patients and correlates with glucose and triglyceride plasma levels[J].Acta Diabetol,2014,51(1):23.
    [23] MAZZOCCOLI G,DAGOSTINO MP,FONTANA A,et al.Influence of the Gly1057Asp variant of the insulin receptor substrate 2(IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly[J].Exp Gerontol,2012,47(12):988.
    [24] SHUSUKE Y,YUKINA H,TAKAYUKI I,et al.Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus[J].Diabetol Metab Syndr,2017,9:78.
    [25] RYOTARO B,MASAHIRO T,YURIKO S,et al.Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes:a pilot study[J].Cardiovasc Diabetol,2017,16:32.
  • [1] 罗涛 . 冠心病患者糖化血红蛋白水平与冠状动脉病变严重程度的关系分析. 蚌埠医学院学报, 2011, 36(5): 499-500.
    [2] 董晓芬 . 2型糖尿病病人颈动脉弹性、内中膜厚度变化与糖化血红蛋白相关性及联合降糖干预作用探究. 蚌埠医学院学报, 2021, 46(3): 352-356. doi: 10.13898/j.cnki.issn.1000-2200.2021.03.020
    [3] 金齐力 , 李曦光 , 韩玮玮 , 韦莉 . 空腹血糖和糖化血红蛋白联合检测在健康体检中的应用研究. 蚌埠医学院学报, 2015, 40(6): 792-794. doi: 10.13898/j.cnki.issn.1000-2200.2015.06.031
    [4] 丁大伟 , 包宗明 . 血清骨保护素和糖化血红蛋白水平与急性冠状动脉综合征的关系探讨. 蚌埠医学院学报, 2013, 37(5): 542-544.
    [5] 徐红 , 陈雯 , 刘敏 . 护理干预结合糖化血红蛋白监测模式改善非增殖型糖尿病视网膜病变的作用. 蚌埠医学院学报, 2013, 37(8): 1072-1073.
    [6] 郭劝劝 , 于磊 . 2型糖尿病目标范围内时间与糖化血红蛋白相关性分析. 蚌埠医学院学报, 2023, 48(2): 233-235. doi: 10.13898/j.cnki.issn.1000-2200.2023.02.023
    [7] 汤凤英 , 桑更生 , 竟雪莹 , 何强先 , 祖磊 . 踝臂指数、颈动脉内膜中层厚度与早发冠心病冠脉病变严重程度的相关性研究. 蚌埠医学院学报, 2018, 43(11): 1453-1455,1459. doi: 10.13898/j.cnki.issn.1000-2200.2018.11.017
    [8] 许承志 , 朱坤 , 王其海 , 崔惠康 . 术前强化他汀治疗对冠心病病人PCI术后心肌标志物及炎性指标的影响. 蚌埠医学院学报, 2017, 42(5): 641-644. doi: 10.13898/j.cnki.issn.1000-2200.2017.05.024
    [9] 徐飞 , 周勇 . 冠心病患者超敏C反应蛋白、同型半胱氨酸水平与脉搏波传导速度的关系. 蚌埠医学院学报, 2013, 37(6): 700-702.
    [10] 章春艳 , 曹政 , 杨勇 , 詹艳 . 冠心病患者Fractalkine、单核细胞趋化蛋白-1和白细胞介素-8的检测及意义. 蚌埠医学院学报, 2016, 41(4): 485-487. doi: 10.13898/j.cnki.issn.1000-2200.2016.04.019
    [11] 徐钢 , 桑更生 , 薛鹏程 , 石世强 , 潘路华 . 冠心病患者冠状动脉病变程度与血尿酸、脑型钠尿肽及超敏C反应蛋白水平的相关性. 蚌埠医学院学报, 2016, 41(7): 866-867,870. doi: 10.13898/j.cnki.issn.1000-2200.2016.07.008
    [12] 杨华 , 吴海清 , 张艳 . 强化降糖配合罗格列酮对老年冠心病合并2型糖尿病病人血脂和载脂蛋白的影响. 蚌埠医学院学报, 2018, 43(6): 778-781. doi: 10.13898/j.cnki.issn.1000-2200.2018.06.023
    [13] 郑徽 , 李雪松 , 张钰 , 沈春芳 , 范玉娟 , 张宁 , 范晓方 , 杨架林 . 新诊断2型糖尿病患者糖化血红蛋白与血清凝集素样氧化低密度脂蛋白受体1关系的研究. 蚌埠医学院学报, 2016, 41(4): 445-447. doi: 10.13898/j.cnki.issn.1000-2200.2016.04.006
    [14] 向瑾操 , 王燕燕 , 黄霄行 , 陈俊虎 . 糖化血红蛋白结合2点血糖法诊断妊娠期糖尿病的可行性研究. 蚌埠医学院学报, 2014, 39(7): 864-867.
    [15] 张国良 , 高云龙 . 2型糖尿病合并小细胞性贫血病人糖化血红蛋白与空腹血糖的相关性分析. 蚌埠医学院学报, 2020, 45(8): 1094-1096. doi: 10.13898/j.cnki.issn.1000-2200.2020.08.027
    [16] 史琼 , 王静 , 陆明 . 血糖目标范围内时间和糖化血红蛋白与2型糖尿病微血管病变的相关性研究. 蚌埠医学院学报, 2023, 48(4): 478-481. doi: 10.13898/j.cnki.issn.1000-2200.2023.04.014
    [17] 黄显元 , 游荔 . 2型糖尿病合并冠心病病人血清超敏C反应蛋白、肿瘤坏死因子-α、高迁移率蛋白B1水平变化及临床意义. 蚌埠医学院学报, 2020, 45(1): 48-50, 56. doi: 10.13898/j.cnki.issn.1000-2200.2020.01.012
    [18] 张宁汝 , 吴继雄 . 冠心病患者血纤维蛋白原和尿酸水平变化的研究. 蚌埠医学院学报, 2007, 32(3): 277-279.
    [19] 刘远友 , 曾金财 , 揭海 , 刘远波 . 血清中性粒细胞明胶酶相关载脂蛋白在冠心病疾病评估及诊断中的作用. 蚌埠医学院学报, 2021, 46(1): 61-64. doi: 10.13898/j.cnki.issn.1000-2200.2021.01.017
    [20] 刘杨 , 谢明水 , 张秋莹 . 组织型纤溶酶原激活物-抑制剂复合物在冠心病病人中表达变化及与预后相关性分析. 蚌埠医学院学报, 2021, 46(10): 1428-1431. doi: 10.13898/j.cnki.issn.1000-2200.2021.10.026
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3147
  • HTML全文浏览量:  501
  • PDF下载量:  44
  • 被引次数: 0
出版历程
  • 收稿日期:  2018-08-02

糖化血红蛋白与冠心病病人心肌外脂肪厚度的相关性研究

    通讯作者: 邵琴, 副主任医师.shaoqindr@126.com; 
    作者简介: 范益博(1985-),男,硕士研究生,住院医师.
  • 1. 上海交通大学医学院附属仁济医院 心内科, 上海 200127;
  • 2. 上海交通大学 医学院, 上海 200025;
  • 3. 上海健康医学院附属浦东新区人民医院 急诊与重症医学科, 上海 201299
  • 收稿日期: 2018-08-02
基金项目:  国家自然科学基金青年基金项目（81500221）；上海市浦东新区医学重点专科建设项目（PWZzk2017-22）

摘要: 目的：探讨糖化血红蛋白水平与冠心病病人心肌外脂肪厚度（epicardial adipose tissue thickness，EATT）的关系。方法：选择入院诊断为冠心病的住院病人共510例，均行冠脉造影检查，并根据造影结果将入选者分为冠心病组和对照组。对所有入选者进行心脏多层螺旋CT扫描，根据CT图像分别测定前降支、回旋支和右冠脉区域的EATT，并计算三者的厚度之和（Total EATT），同时测定血清糖化血红蛋白等指标。结果：冠心病组平均糖化血红蛋白为（6.2±1.2）mmol/L，高于对照组的（5.8±0.8）mmol/L（P<0.01），冠心病组Total EATT（26.33±7.8）mm，高于对照组的（22.72±6.3）mm（P<0.01）。在冠心病病人中，糖化血红蛋白水平与Total EATT呈正相关关系（r=0.207，P<0.01）；多元回归分析表明，糖化血红蛋白与Total EATT呈独立正相关关系（P<0.01）。结论：冠心病病人中，EATT增加可能与糖化血红蛋白水平增高有关。

English Abstract

    全文HTML

参考文献 (25)

目录

    /

    返回文章
    返回

    版权所有© 2019《蚌埠医学院学报》编辑部 皖ICP备06000434号-1

    地址：安徽省蚌埠市东海大道2600号 邮编：233030

    电话：0552-3175456 Email：byxb@vip.163.com

    本系统由 北京仁和汇智信息技术有限公司 开发 技术支持： info@rhhz.net   百度统计